Pleiotropic regulations of neutrophil receptors response to sepsis

Zhang, Huafeng; Sun, Bo

doi:10.1007/s00011-016-0993-3

Cited by 9 publications

(7 citation statements)

References 108 publications

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“…However, treatment of sepsis remains a prominent challenge to clinical practice. Numerous studies focusing on the pathophysiology of sepsis have revealed an imbalance in the inflammatory network, leading to tissue damage, organ failure and ultimately death (Zhang & Sun, ). During the disease progression, many metabolisms (energy metabolism, glycogen syntheses, lipid metabolism, and purine metabolism) are modulated in response to stress conditions.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Wang¹,

Liu²,

Cao³

et al. 2018

Biomedical Chromatography

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This study aimed to investigate the efficacy of mangiferin, including its known antioxidant and anti-inflammatory effects on sepsis-induced lung injury induced by a classical cecal ligation and puncture (CLP) models in mouse using a metabolomics approach. A total of 24 mice were randomly divided into four groups: the sham group was given saline before sham operation. The CLP group received the CLP operation only. HMF and LMF groups were given mangiferin treatment of high dose and low dose of mangiferin, respectively, before the CLP operation. One week after treatment, the mice were sacrificed and their lungs were collected for metabolomics analysis. We developed ultra-performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry to perform lung metabolic profiling analysis. With the methods of principal component analysis and partial least squares discriminant analysis, 58 potential metabolites associated with amino acid metabolism, purine metabolism, lipid metabolism and energy regulation were observed to be increased or reduced in HMF and LMF groups compared with the CLP group. Conclusively, our results suggest that mangiferin plays a protective role in the moderation of sepsis-induced lung injury through reducing oxidative stress, regulating lipid metabolism and energy biosynthesis.

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Section: Introductionmentioning

confidence: 99%

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Wang¹,

Liu²,

Cao³

et al. 2018

Biomedical Chromatography

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“…Neutrophil migration at sites of inflammation is mediated by various chemoattractant receptors, mainly the formyl‐peptide receptors (FPRs), CXC chemokine receptors (CXCRs) and complement factor 5a (C5a) 24 . The formyl‐peptide receptor (FPR) gene cluster in humans has three members: FPR1, FPRL1 and FPR2 25 .…”

Section: Discussionmentioning

confidence: 99%

A novel computer vision‐based assessment of neutrophil chemotaxis in patients with severe infection

et al. 2021

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Objectives To evaluate the value of chemotactic function of neutrophils in patients with severe infections. Methods A computer vision‐based cellular chemotaxis analysis platform was established for the dynamic assessment of neutrophil chemotaxis. Fifty‐three patients in the intensive care unit were eligible for the study. In parallel, 142 healthy volunteers were recruited to detect and establish the normal values for chemotactic function. Four chemotactic function indicators were determined–chemotaxis distance (CD), chemotaxis cell ratio (CCR), chemotaxis index (CI) and maximum speed of chemotaxis (Vmax). The chemotaxis function scores (CFS) were calculated for further correlation analysis with clinical data. Results The normal ranges of indicators were established as CD ≥ 1755.85 µm, CCR ≥ 3.34%, CI ≥ 39.63, Vmax ≥ 14.63 µm min−1 and CFS ≥ 15. We found that the chemotactic function of neutrophils in patients suffering from infections was significantly impaired. The mean values of CD, CCR, CI, Vmax and CFS were 1452.8 µm (P < 0.0001), 3.1% (P < 0.0001), 34.5 (P < 0.0001), 12.2 µm min−1 (P < 0.0001) and 9 (P < 0.0001), respectively. CD and CFS were significantly negatively correlated with the APACHE II score (rCD = −0.55, rCFS = −0.39), SOFA score (rCD = −0.68, rCFS = −0.56), procalcitonin concentration (rCD = −0.60, rCFS = −0.5) and the expression of P2RX1 (rCD = −0.76, rCFS = −0.56), respectively. Conclusions CD, CCR, CI and Vmax can well reflect the neutrophil chemotactic function in patients with severe infections. CFS systematically indicated neutrophil function and has promising clinical application prospects.

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“…Studies concerning the modulation of neutrophil activity by cannabinoids during infections are mostly addressed to experimental bacterial infection as sepsis model. Neutrophil activity during experimental sepsis is well characterized in studies in vivo (to review [97][98][99]). By using LPS sepsis model, Smith and coworkers showed that treatment with cannabinoid receptor agonists reduced the migration of neutrophils in the peritoneal cavity by inhibiting neutrophil chemoattractant production [59].…”

Section: Neutrophils Cannabinoid System and Infectionmentioning

confidence: 99%

Cannabinoid Receptors as Regulators of Neutrophil Activity in Inflammatory Diseases

Souza¹,

Rosas²

2019

Neutrophils

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Cannabinoids are compounds present in Cannabis sativa (phytocannabinoids), endogenously produced (endocannabinoids) or synthesized, that bind to G protein-coupled receptors named cannabinoid receptors B1 and B2. They were first described as psychotropic compounds; however, cannabinoids are also potent immunoregulatory agents. Cannabinoids can modulate neutrophil activity in sterile and infectious inflammatory diseases. Concerning sterile inflammatory diseases as arthritis, ischemic diseases, and colitis, the use of CB2 agonist impairs the intracellular signaling pathways involved in the production of inflammatory mediators and expression of adhesion molecules. As a consequence, neutrophils did not release metalloproteinases either to adhere to endothelial cells, resulting in reduced tissue damage. A similar anti-inflammatory CB2 agonist mechanism of action in sepsis and mycobacterial infection models is observed. However, it is not clear if inflammation resolution promoted by cannabinoid treatment during infection is also related to microbial viability. Despite the growing literature showing the effects of cannabinoids on neutrophils, there are still some gaps that should be filled before proposing cannabinoid-based drugs to treat neutrophil-dependent diseases.

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Pleiotropic regulations of neutrophil receptors response to sepsis

Abstract: Neutrophil receptors play key roles in chemotactic neutrophil migration and may prove to be suitable targets in future pharmacological therapies for sepsis.

Cited by 9 publications

References 108 publications

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

Metabolomic analysis for the protective effects of mangiferin on sepsis‐induced lung injury in mice

A novel computer vision‐based assessment of neutrophil chemotaxis in patients with severe infection

Cannabinoid Receptors as Regulators of Neutrophil Activity in Inflammatory Diseases

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