Pleomorphic Adenoma of the Cervical Esophagus: A Rare Tumor

Banducci, Dennis R.; Rees, Riley S.; Bluett, Michael K.; Sawyers, John L.

doi:10.1016/s0003-4975(10)62156-x

Cited by 19 publications

(8 citation statements)

References 5 publications

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“…Moreover, biopsy specimens from the mucosa overlying the adenomas were reportedly normal in 3 cases, including the present case [6,8], and were diagnosed as adenocarcinoma in 2 cases [2,10]. Thus, histologic examination of biopsy specimens sometimes cannot distinguish these adenomas from other submucosal masses, but can usually distinguish them from mucosal lesions.…”

Section: Discussionmentioning

confidence: 76%

“…We have encountered a case of adenoma that arose in the esophageal submucosa without associated Barrett's mucosa. Only eight such cases have been reported previously [4][5][6][7][8][9][10][11]. We describe the endoscopic and histologic features of our case, and review the previous literature.…”

Section: Introductionmentioning

confidence: 82%

“…The 9 reported adenomas of submucosal origin included one "bronchial adenoma" [4], 1 oncocytoma [5], 1 pleomorphic adenoma [6], and 6 submucosal gland (duct) adenomas [7][8][9][10][11] with histologic features very similar to those of sialadenoma papilliferum of the minor salivary glands [9,10]. Macroscopically these last 6 cases were pedunculated or sessile submucosal tumors with no ulceration (Table 1).…”

Section: Discussionmentioning

confidence: 99%

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Submucosal adenoma of the esophagus: case report and review of the literature

et al. 2004

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A 60-year-old woman complaining of abdominal discomfort was found at endoscopy to have a dome-shaped esophageal polyp, located 22 cm from the incisor teeth and covered by normal epithelium. Histologic examination after endoscopic removal showed a submucosal esophageal gland adenoma. This is the ninth reported case of this entity. Eleven years later, the patient remains well with no evidence of esophageal disease. We review all nine reported cases of submucosal adenoma of the esophagus.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

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Submucosal adenoma of the esophagus: case report and review of the literature

et al. 2004

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“…Some cases have been reported to resemble pleomorphic adenoma of the salivary gland 2 and, more rarely, other cases presumably originated from gland ducts have also been reported. On the basis of their histologic appearance, they have been described as serous cystadenoma, 9 Sialadenoma papilliferum, 7 or submucosal gland duct adenoma.…”

mentioning

confidence: 99%

Esophageal Gland Duct Adenoma: Immunohistochemical Comparison With the Normal Esophageal Gland and Ultrastractural Analysis

Harada¹,

Ota²,

Katsuyama

et al. 2007

American Journal of Surgical Pathology

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Esophageal gland duct adenomas are extremely rare tumors. Here, we report the case of a 75-year-old Japanese man who had undergone total gastrectomy for advanced gastric cancer. Esophageal gland duct adenoma was incidentally found in the lower esophagus. It appeared to be detached from the site of gastric cancer and was well demarcated without a capsule. Histologic analysis revealed papillary and cystic structures mainly comprising eosinophilic cells with minimum nuclear atypia. Immunohistochemical analysis revealed that the tumor were diffusely positive for the S100 protein with preserved alpha-SMA-positive myoepithelial cell layers and a characteristic cytokeratin expression pattern similar to that in normal esophageal gland ducts (CK5/6+++, CK7+++, CK17+, CK18+, CK19+++, CK20-, HMWCK+++). In addition, differentiation into the terminal duct was confirmed by a combination of mucin staining and immunohistochemical and ultrastructural examinations. This is the first report that refers to the ultrastructural findings of an esophageal gland duct adenoma and describes terminal duct differentiation. We believe that the possibility of an esophageal gland duct adenoma should be considered when diagnosing a ductal or glandular lesion of the esophagus.

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“…In the present tumor, the carcinoma components showed variable histological features, especially ductal structures in the myxomatous stroma. Ductal or glandular structures in esophageal tumors are shown in adenocarcinoma, adenoid cystic carcinoma 25 and pleomorphic adenoma 27 . Two cases of adenocarcinoma in carcinosarcoma of the esophagus have been reported previously: carcinosarcoma arising from Barrett's esophagus; 10 and polypoid carcinoma with multidirectional differentiation 12 .…”

Section: Discussionmentioning

confidence: 99%

Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations

Ohtaka

Kumasaka

Nobukawa

et al. 2002

Pathology International

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We report a case of carcinosarcoma of the esophagus characterized by ductal and myoepithelial differentiation. A 61-year-old man was operated on for a polypoid tumor of the distal esophagus. Histologically, this tumor was composed of ductal structures and sarcomatous spindle cells surrounding the ducts at the central area of the tumor. The tumor was also composed of squamous cell and basaloid carcinoma in the periphery. Immunohistochemically, a few spindle cells surrounding the ductal structures showed immunopositivity for alpha-smooth muscle actin and S-100 protein. Electron microscopy revealed that the spindle cells had tonofilament and pinocytic vesicles in the cytoplasm, and basal lamina adjacent to the cytoplasmic membrane. Both of the results strongly supported the suggestion that the spindle cells may be myoepithelial cells. Basaloid carcinoma showed a gradual transition to chondrosarcomatous cells producing the matrix, which had both immunopositivities for S-100 protein and cytokeratin. Therefore, chondrosarcomatous cells may be derived from carcinoma cells. The histogenesis of this tumor may be associated with a totipotent stem cell of esophageal mucosa, which has the potential to differentiate into squamous cells, ductal cells or myoepithelial cells.

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Pleomorphic Adenoma of the Cervical Esophagus: A Rare Tumor

Cited by 19 publications

References 5 publications

Submucosal adenoma of the esophagus: case report and review of the literature

Submucosal adenoma of the esophagus: case report and review of the literature

Esophageal Gland Duct Adenoma: Immunohistochemical Comparison With the Normal Esophageal Gland and Ultrastractural Analysis

Carcinosarcoma of the esophagus characterized by myoepithelial and ductal differentiations

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