Pleural mesothelial sequestration of iron in the rat

May, E. E.; May, Meghan Ellinger

doi:10.3109/00313028409059088

Cited by 4 publications

(4 citation statements)

References 11 publications

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“…Intracytoplasmic erythrocytes and lamellar inclusions were noted in the cytoplasm of mesothelial cells 6 . Accumulation of iron has been reported in the cytoplasm of mesothelial cells from humans and rats given parenteral iron 8,9 . In the present case, the iron within mesothelial cells was likely secondary to hemorrhage, based on the erythrophagia and accumulation of hemosiderin in macrophages.…”

Section: Discussionsupporting

confidence: 48%

What is your diagnosis? Hemorrhagic effusion in a dog

Barger¹,

Riensche

2009

Veterinary Clinical Pathol

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A 2-year-old spayed female, German Shepherd dog was presented to the University of Illinois Veterinary Teaching Hospital with a history of intermittent lethargy. On physical examination, lung sounds were increased. The dog had a mild fever (103.7 degrees F) and mild tachycardia (120 bpm). Thoracic ultrasound revealed a sternal mass and pericardial effusion, both of which were aspirated. On cytologic examination, the pericardial fluid contained a large amount of blood and was interpreted as a hemorrhagic effusion. Nucleated cells consisted mainly of macrophages containing phagocytized RBCs and hemosiderin and many clusters of reactive mesothelial cells. The majority of mesothelial cells contained variable amounts of rod-shaped brown pigment granules that were suspected to be iron. The granules were positive for Prussian blue and carbol-fuschin, indicative of iron potentially mixed with lipofuscin. The granules stained negatively with Melan A, rhodamine, Hall's, and periodic acid-Schiff. The iron within the mesothelial cells was likely secondary to hemorrhage, based on the erythrophagia and accumulation of hemosiderin in macrophages. Iron deposition and phagocytic activity in mesothelial cells has been reported previously in humans and rats, but not in dogs.

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Section: Discussionsupporting

confidence: 48%

What is your diagnosis? Hemorrhagic effusion in a dog

Barger¹,

Riensche

2009

Veterinary Clinical Pathol

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“…Intraperitoneal injection of ferric saccharate in rats for 3 months results in the development of peritoneal mesothelioma [16]. In rats loaded with parenteral iron, deposition of that ion was found in pleural mesothelial cells [17]. This risk is lower in renal patients treated with peritoneal dialysis who are exposed to iron intermittently.…”

Section: Discussionmentioning

confidence: 99%

Adverse effects of iron toward the peritoneal mesothelial cells are reversible

Jasiński

Bręborowicz

2022

Ther Apher Dial

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Introduction Evaluation of the effects of the drugs used for iron supplementation on the peritoneal mesothelial cells. Methods Acute effects during18‐h incubation of iron sucrose, ferric carboxymaltose, and iron isomaltoside in concentrations 1, 5, and 20 ug/dl on properties of the human peritoneal mesothelial cells in in vitro culture were evaluated, and their reversibility after the following culture for 14 days in the iron‐free medium was studied. Results All studied compounds reduced viability of mesothelial cells and proliferation rate and increased intracellular oxidative stress and iron content in the cytosol. Secretion of monocyte chemoattractant protein‐1 was increased and tissue plasminogen activator (t‐PA) decreased. After 14 days of culture in iron‐free medium, reversibility of all these effects was observed. Conclusion Iron compounds impair the functional properties of mesothelial cells in a dose‐dependent manner, but these effects are reversible after the following culture of the cells in an iron‐free medium.

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“…In another study, Shaw et al described the phagocytic activity of mesothelial cells in human peritoneal mesothelial cells via in vitro studies 5,6 . Additionally, a few studies have described the presence of haemosiderin‐laden mesothelial cells in rats and dogs 7,8 . Marotti et al 9 described the presence of haemosiderin‐laden mesothelial cells in pericardial fluid.…”

Section: Figurementioning

confidence: 99%