Pluralisme thérapeutique et société

Rossi, Ilario

doi:10.3917/crpsy.002.0052

Cited by 3 publications

(3 citation statements)

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“…These assays have recently been applied to CSF and autopsied submandibular gland tissues. [29][30][31][32][33][34]37,43 However, because of the invasive nature of lumbar puncture for CSF collection, it is not practical to collect CSF for routine early detection of αSyn P during clinical visits or for serial evaluation during clinical trials. Moreover, lumbar puncture for CSF sampling is not always feasible because of relative contraindications, such as anticoagulation, particularly common in elderly patients.…”

Section: Discussionmentioning

confidence: 99%

“…27,28 It was recently adapted to detect αSyn P seeding activity in the brain and/or CSF samples from individuals with PD and LBD with 92% to 95% sensitivity and 100% specificity. [29][30][31][32][33][34] Protein misfolding cyclic amplification (PMCA) is another assay that has been used to detect trace amounts of misfolded prion protein aggregates in skin tissues of prion-infected mice or body fluids of patients with prion diseases. 28,35,36 A modified version of PMCA was previously shown to detect αSyn P in the CSF of patients with PD.…”

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confidence: 99%

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Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

et al. 2021

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Key Points Question Does the pathological α-synuclein (αSyn P ) detected by immunohistochemistry in the skin of individuals with Parkinson disease (PD) have aggregation seeding activity, and is skin αSyn P seeding activity a potential biomarker for diagnosis of PD and other synucleinopathies? Findings In this diagnostic study including skin samples from 160 autopsies and 41 biopsies, a statistically significant increase in αSyn P seeding activity was observed in individuals with PD and synucleinopathies compared with controls with tauopathies and nonneurodegenerative diseases. Meaning Skin αSyn P has aggregation seeding activity in patients with PD and non-PD synucleinopathies and may be a biomarker for antemortem diagnosis of PD and other synucleinopathies.

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confidence: 99%

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confidence: 99%

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

et al. 2021

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“…Campana et al 2012). Alternatively, the continuum discontinuity could be the 400 nm break at z = 0.71; such feature is however prominent only in early-type galaxies, which are unlikely hosts of long-duration GRBs (but see Rossi et al 2014). Given the lack of optical variability, it cannot be excluded that the object within the XRT error circle is a chance association, as the probability of a random alignment is small but non negligible (of the order of 1%).…”

Section: Appendix B: Notes On Individual Objectsmentioning

confidence: 99%

The X-shooter GRB afterglow legacy sample (XS-GRB)

Selsing

Malesani

Goldoni

et al. 2019

A&A

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In this work we present spectra of all γ-ray burst (GRB) afterglows that have been promptly observed with the X-shooter spectrograph until 31/03/2017. In total, we obtained spectroscopic observations of 103 individual GRBs observed within 48 hours of the GRB trigger. Redshifts have been measured for 97 per cent of these, covering a redshift range from 0.059 to 7.84. Based on a set of observational selection criteria that minimize biases with regards to intrinsic properties of the GRBs, the follow-up effort has been focused on producing a homogeneous sample of 93 afterglow spectra for GRBs discovered by the Swift satellite. We here provide a public release of all the reduced spectra, including continuum estimates and telluric absorption corrections. For completeness, we also provide reductions for the 18 late-time observations of the underlying host galaxies. We provide an assessment of the degree of completeness with respect to the parent GRB population, in terms of the X-ray properties of the bursts in the sample and find that the sample presented here is representative of the full Swift sample. We constrain the fraction of dark bursts to be < 28 per cent and we confirm previous results that higher optical darkness is correlated with increased X-ray absorption. For the 42 bursts for which it is possible, we provide a measurement of the neutral hydrogen column density, increasing the total number of published HI column density measurements by ∼ 33 per cent. This dataset provides a unique resource to study the ISM across cosmic time, from the local progenitor surroundings to the intervening universe.Article number, page 19 of 43 A&A proofs: manuscript no. XSGRB_sample_arxiv Cité, 10, Rue Alice Domon et Léonie Duquet, 75205,

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Quelle santé et quelle autonomie à la fin de la vie ?

Camus¹

2021

Fins De Vie Plurielles

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Pluralisme thérapeutique et société

Cited by 3 publications

References 5 publications

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease

The X-shooter GRB afterglow legacy sample (XS-GRB)

Quelle santé et quelle autonomie à la fin de la vie ?

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