Plurihormonal pituitary adenomas: immunostaining of all pituitary hormones is mandatory for correct classification

Ho, Donald Ming‐Tak; Hsu, Chih-Yi; Ting, Ling-Tan; Chiang, Hung‐Ting

doi:10.1046/j.1365-2559.2001.01204.x

Cited by 41 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plurihormonal adenomas are defined as secreting two or more hormones that differ in chemical composition, immunoreactivity, and biologic effects. [7][8][9] Plurihormonal adenomas include functioning and nonfunctioning adenomas. [7][8][9][10][11] Ultrastructurally, plurihormonal adenomas may be monomorphous, bimorphous, or plurimorphous.…”

mentioning

confidence: 99%

“…[7][8][9] Plurihormonal adenomas include functioning and nonfunctioning adenomas. [7][8][9][10][11] Ultrastructurally, plurihormonal adenomas may be monomorphous, bimorphous, or plurimorphous. 7,8 Immunohistochemic staining may show complex staining profiles of seven adenohypophysial hormones.…”

mentioning

confidence: 99%

“…7,8 Immunohistochemic staining may show complex staining profiles of seven adenohypophysial hormones. 9 The underlying factors causing plurihormonality and plurimorphology are not well understood. Most pituitary adenomas are monoclonal, [12][13][14] but the clonality of plurihormonal adenomas is less well known.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathologic study of 123 cases of prolactin‐secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas

Ikeda

Yoshimoto

2002

Cancer

View full text Add to dashboard Cite

BACKGROUNDProlactinoma is the most invasive type of pituitary adenoma and is generally believed to be well‐differentiated adenoma and to produce only prolactin (PRL). The factors related to the various biologic behaviors occurring in patients of different ages and sexes await clarification. Since different immunophenotypes of adenoma may show different biologic behaviors and responses to medical agents, the authors examined hormone production and tried to clarify the clonality of plurihormonal prolactinoma.METHODSClinicopathologic factors were studied in 123 patients with prolactinomas (40 males and 83 females). The specimens were fixed in either 10% neutral buffered formalin or 70% alcohol and used for light microscopy. Alcohol‐fixed tissue was used to extract DNA from 26 samples obtained from female patients for human androgen receptor gene (HUMARA) assay.RESULTSSixty one cases (50%) were pure prolactinoma and 62 cases (50%) were plurihormonal prolactinoma. Spearman rank correlation analysis revealed a significant relationship between age and serum PRL level (P = 0.0002), age and tumor volume (P < 0.0001), and tumor volume and serum PRL level (P < 0.0001). Multiple regression analysis showed a significant correlation only between tumor volume and serum PRL level. The Mann‐Whitney U test revealed that prolactinomas associated with higher PRL levels, larger adenomas, and higher ages were significantly more invasive to the cavernous sinus and that male patients had significantly higher PRL levels and larger adenomas. The HUMARA assay disclosed that 11 of 13 plurihormonal prolactinomas (85%) were compatible with monoclonal origin.CONCLUSIONSThe current results suggest that not only can various hormones other than PRL be secreted by prolactinoma, but also that most multihormone‐producing prolactinomas are monoclonal in origin. Cancer 2002;95:258–66. © 2002 American Cancer Society.DOI 10.1002/cncr.10676

show abstract

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Clinicopathologic study of 123 cases of prolactin‐secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas

Ikeda

Yoshimoto

2002

Cancer

View full text Add to dashboard Cite

show abstract

“…Some of the hormonal profiles observed in our plurihormonal microadenomas deviate from typical pattern included in WHO classification. Unusual profiles were described in pituitary adenomas [27], although it cannot be excluded that some hormonecontaining cells present in our plurihormonal microadenomas can represent entrapped normal adenohypophyseal Microvessel area (MVA) % b a Fig. 5 Microvessel density (a) and microvessel area (b) in hormonally immunonegative and immunopositive microadenomas.…”

Section: Discussionmentioning

confidence: 93%

Microvessel Density and Area in Pituitary Microadenomas

et al. 2009

View full text Add to dashboard Cite

Microvessel density (MVD) and area (MVA) were assessed in 53 clinically silent pituitary microadenomas and in surrounding normal pituitary tissue using CD34 immunostaining and digital image analysis system. Twenty-one microadenomas (40%) were avascular; in the others, both MVD and MVA were significantly lower than in the normal pituitary tissue. No significant differences in MVD and MVA were found between hormonally immunonegative and immunopositive tumors or between different hormonal subtypes of immunopositive microadenomas. In microadenomas and in normal pituitary tissue, MVD and MVA were not significantly influenced by age or sex. These results suggest that pituitary adenomas at early developmental stage are either avascular or significantly less vascular than normal pituitary tissue and that differences in vascularity of pituitary adenomas associated with the variables of sex, age, clinical presentation and immunohistochemical phenotype reported in the literature can evolve with tumor growth and possibly acquire statistical significance in large macroadenomas.

show abstract

“…Approximately 25% of these adenomas may cosecrete another pituitary hormone, including growth hormone, prolactin, or another glycoprotein hormone (folliclestimulating hormone, luteinizing hormone, or alpha subunit), leading to acromegaly or an excess of prolactin (1,5,8,11).…”

Section: Thyrotropin Pituitary Adenomasmentioning

confidence: 99%

Thyrotropin Pituitary Adenomas

Angelis

Cappabianca

2014

World Neurosurgery

View full text Add to dashboard Cite

Plurihormonal pituitary adenomas: immunostaining of all pituitary hormones is mandatory for correct classification

Abstract: Plurihormonal adenomas are common pituitary adenomas. Immunohistochemical staining of all pituitary hormones is mandatory for correct classification.

Cited by 41 publications

References 20 publications

Clinicopathologic study of 123 cases of prolactin‐secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas

Clinicopathologic study of 123 cases of prolactin‐secreting pituitary adenomas with special reference to multihormone production and clonality of the adenomas

Microvessel Density and Area in Pituitary Microadenomas

Thyrotropin Pituitary Adenomas

Contact Info

Product

Resources

About