pMDI Sprays: Theory, Experiment and Numerical Simulation

Oliveira, Ricardo F.; Teixeira, Senhorinha; Teixeira, José Carlos; Silva, Luís F.; Antunes, Henedina

doi:10.5772/46099

Cited by 5 publications

(2 citation statements)

References 32 publications

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“…Geometrical representation pMDI Inhaler dimension was referred from previous literature on the pMDI Sprays: theory, experiment and numerical simulation [21]. Based on the simulation results performed by Ricardo F. Oliveira et al, [19] it is possible to determine the base design diameter for pMDI units, the diameter of the orifice being 0.49 mm, the angle of the actuator being 165 o and the length of the orifice being 1.50 mm. A parameter was used to define the geometry of the actuator nozzle was orifice diameter (D), length of the orifice (L) and angle of the actuator (θ) that shown in Figure 2…”

Section: Methodology 21 Geometrical Modellingmentioning

confidence: 99%

“…Previous researcher Cheng et al, [18] reported that the spray angle for propellant HFA and CFC are 35 o , nevertheless, the Oliveira et al, [19] suggest that the HFA-pMDI angle is 10 o and 17 o . Crosland et al, [20] experimental particle image velocimetry (PIV) shows that the spray cone angle was unstable and varied up to 8 o during the first 100 msec of the transient spray case.…”

Section: Introductionmentioning

confidence: 95%

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Influence of Actuator Nozzle Angle on the Flow Characteristics in Pressurized-Metered Dose Inhaler Using CFD

Rahman¹,

Asmuin²,

Taib³

et al. 2020

CFDL

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Pressurized metered dose inhalers (pMDIs) are often used for the treatment of asthma and chronic obstructive pulmonary disease. This device is easy to carry, highly effective and extremely safe, allowing reliable, consistent dosage delivery, metered dose inhalers are the inhalation devices that doctors and patients can readily select from around the world. This pMDI inhaler system has a problem which is the particle does not penetrate into the alveolar. ANSYS Fluent Version 19.2 was used to find the best angle of the actuator nozzle by parametric analysis. Standard K-epsilon was used as the turbulence model with enhanced wall treatment function. Discrete phase model (DPM) was applied to represent the particle flow. The result shows the best actuator nozzle angle is 120-degree which affects the maximum magnitude of particle velocity.

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Section: Methodology 21 Geometrical Modellingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 95%

Influence of Actuator Nozzle Angle on the Flow Characteristics in Pressurized-Metered Dose Inhaler Using CFD

Rahman¹,

Asmuin²,

Taib³

et al. 2020

CFDL

View full text Add to dashboard Cite

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A CFD Study of a pMDI Plume Spray

Oliveira

Ferreira

Teixeira

et al. 2014

Transactions on Engineering Technologies

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Asthma is an inflammatory chronic disease characterized by airway obstructions disorders. The treatment is usually done by inhalation therapy, in which pressurized metered-dose inhalers (pMDIs) are a preferred device. The objective of this paper is to characterize and simulate a pMDI spray plume by introducing realistic factors through a computational fluid dynamics (CFD) study. Numerical simulations were performed with Fluent® software, by using a three-dimensional "testbox" for room environment representation. An HFA-134a with salbutamol formulation was used for characterization, whose were taken as input for the CFD simulations. Spray droplets were considered to be composed by ethanol, salbutamol and HFA-134a. Propellant evaporation was taken into consideration, as well as, drag coefficient correction. Results showed an air temperature drop of 3.3 °C near the nozzle. Also, an increase in air velocity of 3.27 m/s was noticed. The CFD results seem to be in good agreement with Dunbar (1997) data on particle average velocity along the axial distance from the nozzle.

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