Pneumatic tube transport affects platelet function measured by multiplate electrode aggregometry

Thalén, Simon; Forsling, Ida; Eintrei, Jaak; Söderblom, Lisbeth; Antović, Jovan P.

doi:10.1016/j.thromres.2013.04.020

Cited by 29 publications

(31 citation statements)

References 21 publications

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“…In comparison, previously published studies on the subject of PTS effects on platelet aggregation tests were designed with 12 to 58 subjects ( 18 - 23 ) (Table 1). Two studies, comprising 58 and 50 individuals, observed significant influence on impedance WBA with a Multiplate ® analyzer ( 20 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

“…Two studies, comprising 58 and 50 individuals, observed significant influence on impedance WBA with a Multiplate ® analyzer ( 20 , 23 ). In both studies, detailed information about speed of sample transport and other characteristics of the PTS, that may strongly affect pre-analytical quality are lacking.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison Dyszkiewicz-Korpanty et al recruited 27 healthy volunteers and used collagen (2 µg/mL), ADP (10 µmol/L) and AA (0.5 mmol/L) to perform impedance WBA ( 18 ), whereas Hübner et al recruited 15 healthy subjects and used collagen (2 µg/mL and 5 µg/mL), ADP (10 µmol/L) and ristocetin (1.25 g/L) to perform optical LTA ( 20 ). One previously published study about PTS effects on the Multiplate ® system was performed with 58 individuals (32 healthy individuals, 14 patients with cardiovascular disease treated with aspirin and/or clopidogrel, 8 patients from an ICU, and 4 patients from a coagulation clinic) using final concentrations of 0.0032 µg collagen, 0.0065 µmol ADP, 0.4839 µmol AA, 0.3076 µg ristocetin and 0.0322 µmol TRAP in each corresponding well ( 23 ). Another study on the Multiplate ® system evaluated 50 patients with acetyl-salicylate acid therapy using AA (0.5 mmol/L) and TRAP (32 µmol/L) only ( 20 ).…”

Section: Discussionmentioning

confidence: 99%

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Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy

Enko¹,

Mangge²,

Münch

et al. 2017

Biochem Med

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IntroductionThe aim of this study was to assess pneumatic tube system (PTS) alteration on platelet function by the light transmission aggregometry (LTA) and whole blood aggregometry (WBA) method, and on the results of platelet count, prothrombin time (PT), activated partial thromboplastin time (APTT), and fibrinogen.Materials and methodsVenous blood was collected into six 4.5 mL VACUETTE® 9NC coagulation sodium citrate 3.8% tubes (Greiner Bio-One International GmbH, Kremsmünster, Austria) from 49 intensive care unit (ICU) patients on dual anti-platelet therapy and immediately hand carried to the central laboratory. Blood samples were divided into 2 Groups: Group 1 samples (N = 49) underwent PTS (4 m/s) transport from the central laboratory to the distant laboratory and back to the central laboratory, whereas Group 2 samples (N = 49) were excluded from PTS forces. In both groups, LTA and WBA stimulated with collagen, adenosine-5’-diphosphate (ADP), arachidonic acid (AA) and thrombin-receptor-activated-peptide 6 (TRAP-6) as well as platelet count, PT, APTT, and fibrinogen were performed.ResultsNo statistically significant differences were observed between blood samples with (Group 1) and without (Group 2) PTS transport (P values from 0.064 – 0.968). The AA-induced LTA (bias: 68.57%) exceeded the bias acceptance limit of ≤ 25%.ConclusionsBlood sample transportation with computer controlled PTS in our hospital had no statistically significant effects on platelet aggregation determined in patients with anti-platelet therapy. Although AA induced LTA showed a significant bias, the diagnostic accuracy was not influenced.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy

Enko¹,

Mangge²,

Münch

et al. 2017

Biochem Med

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“…Immediately following collection, samples were processed using rotational thromboelastometry or sent to the central hospital laboratory for analysis. Samples were delivered to the laboratory in person because pneumatic tube transport systems have been shown to affect determinations made with MEA [8,9].…”

Section: Samplingmentioning

confidence: 99%

Effect of fluid resuscitation with balanced solutions on platelets: In vitro simulation of 20% volume substitution

Krzych¹,

Czempik²

2013

Cardiol J.

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“…Pneumatic transport is well described for biologic sample transport and, in this case, the literature highlights the risk of change, damage, haemolysis and activity loss [3][4][5][6].…”

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confidence: 99%

Innovation in the Transport of Cytotoxic Drugs by a Pneumatic Transport System

Baillie

Desplanques

Delbey

et al. 2017

Pharmaceutical Technology in Hospital Pharmacy

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AbstractMany chemotherapeutic compounding units are confronted with the problem of product delivery to different care wards. We think that transport by a pharmacy agent does not permit appropriate traceability (wrong care service delivery), control of storage temperature and management of urgency. We have developed a delivery system based on the association of a pneumatic transport system (PTS) and monitored buffer storage area. Thus, after pharmaceutical inspection, chemotherapies are placed in specific and hermetic carriers in the PTS but not directly delivered to care units. In the monitored buffer storage, a robotic arm organizes chemotherapies and waits for the nurse call just before administration. This system permits a real traceability for each stage of the chemotherapy circuit and so, we are now able to certify that chemotherapeutics have been maintained at the correct temperature through continual monitoring. It’s an important prerequisite in standardization and reassignment. Finally, an important issue linked to the use of PTS is the risk of damaging the chemotherapeutics. Data obtained from literature and manufacturers for antibodies highlight the low risk to use a PTS.

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Pneumatic tube transport affects platelet function measured by multiplate electrode aggregometry

Cited by 29 publications

References 21 publications

Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy

Pneumatic tube system transport does not alter platelet function in optical and whole blood aggregometry, prothrombin time, activated partial thromboplastin time, platelet count and fibrinogen in patients on anti-platelet drug therapy

Effect of fluid resuscitation with balanced solutions on platelets: In vitro simulation of 20% volume substitution

Innovation in the Transport of Cytotoxic Drugs by a Pneumatic Transport System

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