Point-of-Care Testing for Multiple Cardiac Markers Based on a Snail-Shaped Microfluidic Chip

Yin, Binfeng; Wan, Xinhua; Qian, Changcheng; Sohan, A S M Muhtasim Fuad; Wang, Songbai; Zhou, Teng

doi:10.3389/fchem.2021.741058

Cited by 30 publications

(13 citation statements)

References 33 publications

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“…Their detection approach shows the high-throughput capability by quantifying both IgG and IgM antibodies directly from COVID-19-positive patient plasma samples in a single instrument run. 198 Yin et al reported a sandwich structure snail-shaped microfluidic chip for the multiplex detection of cardiac markers including cTnI, CK-MB, and Myo with high sensitivity and a short detection time using the chemiluminescence method 188 (Fig. 5B).…”

Section: Multiplex Detectionmentioning

confidence: 99%

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Liu¹,

Lu²,

Zhang³

et al. 2023

Lab Chip

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Section: Multiplex Detectionmentioning

confidence: 99%

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Liu¹,

Lu²,

Zhang³

et al. 2023

Lab Chip

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“…They designed a microfluidic chip by utilizing a chemiluminescence (CL) detector and coating the middle of the chip, which has reaction layer based on particular antibodies. Thus, they obtained a POCT candidate which is able to diagnose three AMI-related biomarkers with higher sensitivity and within a short time of period [ 236 ].…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Biomedical Applications of Microfluidic Devices: A Review

et al. 2022

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Both passive and active microfluidic chips are used in many biomedical and chemical applications to support fluid mixing, particle manipulations, and signal detection. Passive microfluidic devices are geometry-dependent, and their uses are rather limited. Active microfluidic devices include sensors or detectors that transduce chemical, biological, and physical changes into electrical or optical signals. Also, they are transduction devices that detect biological and chemical changes in biomedical applications, and they are highly versatile microfluidic tools for disease diagnosis and organ modeling. This review provides a comprehensive overview of the significant advances that have been made in the development of microfluidics devices. We will discuss the function of microfluidic devices as micromixers or as sorters of cells and substances (e.g., microfiltration, flow or displacement, and trapping). Microfluidic devices are fabricated using a range of techniques, including molding, etching, three-dimensional printing, and nanofabrication. Their broad utility lies in the detection of diagnostic biomarkers and organ-on-chip approaches that permit disease modeling in cancer, as well as uses in neurological, cardiovascular, hepatic, and pulmonary diseases. Biosensor applications allow for point-of-care testing, using assays based on enzymes, nanozymes, antibodies, or nucleic acids (DNA or RNA). An anticipated development in the field includes the optimization of techniques for the fabrication of microfluidic devices using biocompatible materials. These developments will increase biomedical versatility, reduce diagnostic costs, and accelerate diagnosis time of microfluidics technology.

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“…As an emerging manufacturing technology, 3D printing has the characteristics of individuation and high precision. It has been widely used in miniaturized mechanical and electromechanical elements to efficiently manufacture microdevices in recent years [28,29]. We used a high-precision desktop 3D printer to make the molds of the microfluidic chip (Figure 1a).…”

Section: Design and Fabrication Of The Microfluidic Chipmentioning

confidence: 99%

Enzyme Method-Based Microfluidic Chip for the Rapid Detection of Copper Ions

et al. 2021

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Metal ions in high concentrations can pollute the marine environment. Human activities and industrial pollution are the causes of Cu2+ contamination. Here, we report our discovery of an enzyme method-based microfluidic that can be used to rapidly detect Cu2+ in seawater. In this method, Cu2+ is reduced to Cu+ to inhibit horseradish peroxidase (HRP) activity, which then results in the color distortion of the reaction solution. The chip provides both naked eye and spectrophotometer modalities. Cu2+ concentrations have an ideal linear relationship, with absorbance values ranging from 3.91 nM to 256 μM. The proposed enzyme method-based microfluidic chip detects Cu2+ with a limit of detection (LOD) of 0.87 nM. Other common metal ions do not affect the operation of the chip. The successful detection of Cu2+ was achieved using three real seawater samples, verifying the ability of the chip in practical applications. Furthermore, the chip realizes the functions of two AND gates in series and has potential practical implementations in biochemical detection and biological computing.

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Point-of-Care Testing for Multiple Cardiac Markers Based on a Snail-Shaped Microfluidic Chip

Cited by 30 publications

References 33 publications

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Printable biosensors towards next-generation point-of-care testing: paper substrate as an example

Biomedical Applications of Microfluidic Devices: A Review

Enzyme Method-Based Microfluidic Chip for the Rapid Detection of Copper Ions

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