Pola Penyakit dan Karakteristik Pasien Hemato- Onkologi Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Udayana/RS Sanglah Denpasar Periode 2000-2005

Mudita, Ida Bagus

doi:10.14238/sp9.1.2007.13-6

Cited by 2 publications

(1 citation statement)

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“…Only limited samples were collected because of limited patients, cell viability, and availability of reagents. Based on Mudita (2007), the total ALL cases on children at Sanglah Hospital were 51 cases on the period of 2000-2005 [8].…”

Section: Resultsmentioning

confidence: 99%

P-Glycoprotein Expression on Patients with Acute Lymphoblastic Leukemia

Niiruri

Narayani

Ariawati

et al. 2017

JHSM

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Abstract Objective: P-glycoprotein (P-gp) overexpression on neoplastic cells can deteriorate the therapeutic outcome on cancer patients. P-gp plays important role on drug efficacy and toxicity. This research aimed to measure P-gp expression on children with Acute Lymphoblastic Leukemia (ALL) on Sanglah Hospital, Denpasar. Method: Flowcytometry method was used to measure P-gp expression level on Bone Marrow samples from pediatric patients (0-12 years old) who were newly diagnosed with ALL in Sanglah Hospital. P-gp overexpression were based on the percentage of cell stained. Ten percent of P-gp expression were considered as the cut-off value of P-gp overexpression. Result: On this study, 11 samples were obtained with the range value of 56-97% on P-gp expression. Conclusion: All 11 patients had P-gp overexpression.

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Section: Resultsmentioning

confidence: 99%

P-Glycoprotein Expression on Patients with Acute Lymphoblastic Leukemia

Niiruri

Narayani

Ariawati

et al. 2017

JHSM

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Pathological Risk Factor Profile for Enucleated Retinoblastoma at Sanglah General Hospital

Yuliawati

Ekawati

2018

Biomed. Pharmacol. J

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Retinoblastoma is a primary intraocular tumor on childhood. It has a good prognosis with early detection. Aim of this study is to know Pathological Risk Factors (PRF) profile of enucleated retinoblastoma at Sanglah General Hospital. This study is an observational retrospective study based on patient’s medical record and pathological examination. Twenty patients were included in this study, 50% were female and 50% male within age ranging from 7 month – 12 years old. Unilateral retinoblastoma was found in 18 patients (90.5%), bilateral retinoblastoma was found in 2 patients (9.5%). Majority PRF profile found that cancer cell invasions was 60% choroid infiltration and 45% of anterior segment invasion, 60% of optic nerve infiltration, and 50.1% scleral invasion. Tumor cell aggregation showed 61.9% poorly differentiated malignant cells. None of the patients had family history of retinoblastoma. This study revealed optic nerve and choroid invasion were the major PRF found in retinoblastoma, but there is a significant association between scleral infiltration and tumor cell differentiation (p = 0.025). There was no statistical difference of PRF based on age, gender, and laterality.

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Pola Penyakit dan Karakteristik Pasien Hemato- Onkologi Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Udayana/RS Sanglah Denpasar Periode 2000-2005

Cited by 2 publications

References 0 publications

P-Glycoprotein Expression on Patients with Acute Lymphoblastic Leukemia

P-Glycoprotein Expression on Patients with Acute Lymphoblastic Leukemia

Pathological Risk Factor Profile for Enucleated Retinoblastoma at Sanglah General Hospital

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