Poly(2-oxepane-1,5-dione):  A Highly Crystalline Modified Poly(ε-caprolactone) of a High Melting Temperature

Non-invasive deep tissue imaging of iodine modified poly(caprolactone-co-1-4-oxepan-1,5-dione) using X-ray

“…We hypothesized that a chemically-modified poly(caprolactone-co-1-4-oxepan-1,5-dione) P(CLcoOPD) could provide X-ray contrast in deep tissue and that the contrast would decrease during degradation because of the gradual decrease of iodine content in the implant [12]. The rationale of iodine functionalized P(CLcoOPD) as radiographic contrast agent is based on the fact that polycaprolactone is approved by the FDA for clinical applications and iodine is commonly used in the clinic as a radiographic contrast agent to distinguish water from soft tissues.…”

Novel Aliphatic Polyesters Based on Functional Cyclic (Di)Esters

“…The first example of the controlled synthesis of functional aliphatic polyesters is the polymerization of 1,4,8-trioxa(4,6)spiro-9-undecanone (or 5-ethylene ketal e-caprolactone, 18a), which is readily synthesized by one-step oxidation of the commercially available monoethylene ketal of 1,4-cyclohexanedione. [61][62][63] 18a is homopolymerized in a ''living'' manner when initiated with Al(O i Pr) 3 in toluene at 25 8C. As a result, well-defined homopolymers (18b) and random and block copolymers containing eCL could be prepared.…”

“…150 8C) and with the potential of being photodegradable. [63] To prepare 18c in a more straightforward way, eCL containing an inner ketone in g-position (19a) has been prepared by Bayer-Villiger oxidation of 1,4-cyclohexanedione and polymerization using a tin catalyst. [64] Other methods to prepare poly(eCL) containing pendant hydroxyl groups have been reported.…”

Synthesis and characterization of α‐amino acid‐containing polyester: poly[(ε‐caprolactone)‐co‐(serine lactone)]

“…This has prompted several groups to explore functional monomers to copolymerize with CL. Monomers with ketone groups, azide groups, halide groups, hydroxyl groups and amino groups, have been successfully developed with a view to introducing their functional groups to PCL. However, in most cases, the synthesis of the functional monomers is a complicated and time‐consuming task, sometimes including several steps of column chromatography purification.…”