Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair

Shen, Jiafu; Zhou, Ziwei; Chen, Danyang; Wang, Yong; He, Yingna; Wang, Dong; Qin, Jianglei

doi:10.1016/j.colsurfb.2021.111568

Cited by 21 publications

(12 citation statements)

References 67 publications

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“…In addition, some self-healing hydrogels have antibacterial and anti-infection properties. and they were used for wound repair by carrying related drugs ( Zhao et al, 2017 ; Shen et al, 2021 ). At the same time, the method of adapting hydrogel to the bone tissue environment by changing its stiffness has also been increasingly applied in bone tissue engineering ( Dubey et al, 2020 ; Ji et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Luo

Tan

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation. The researches on this point are meaningful to the field of tissue engineering. Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs. In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed. Finally, the future application of hydrogels with a certain stiffness in regenerative medicine and tissue engineering has been prospected.

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Section: Introductionmentioning

confidence: 99%

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Luo

Tan

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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“…Qin et al. prepared the hydrogel by reacting poly(aspartic acid) derivatives with PVA, which were l -aspartic Acid with quaternary ammonium and boric acid groups, and the quaternary ammonium salts in the l -aspartic Acid endowed the hydrogel good bactericidal properties [ 149 ].…”

Section: Antibacterial Hydrogel Wound Dressingsmentioning

confidence: 99%

Recent progress of antibacterial hydrogels in wound dressings

Jia¹,

Li²,

Cao³

et al. 2023

Materials Today Bio

106

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“…Injectable hydrogels based on dopamine‐functionalized 4‐arm PEG and phenylboronic acid‐modified 4‐arm PEG exhibited G ′ values of 20 kPa and short self‐healing times of 30 s. [ 65 ] In another example, PVA was mixed with poly(aspartic acid) derivatives bearing quaternary ammonium groups with bactericidal properties and boronic acid groups to yield materials with G′ values of 200–400 Pa with fast (1 min) or slow (up to 12 h) healing times. [ 66 ]…”

Section: Degradable Network With Self‐healing Properties Based On Dyn...mentioning

confidence: 99%

Degradable Self‐healable Networks for Use in Biomedical Applications

Grosjean

Gangolphe

Nottelet

2023

Adv Funct Materials

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Among biomaterials, 3D networks with capacities to absorb and retain large quantities of water (hydrogels) or withstand significant deformation and stress while recovering their initial structures at rest (elastomers) are largely used in biomedical applications. However, when damaged, they cannot recover their initial structures and properties. To overcome this limitation and satisfy the requirements of the biomedical field, self-healable hydrogels and elastomers designed using (bio)degradable or bioeliminable polymer chains have been developed and are becoming increasingly popular. This review presents the latest advances in the field of self-healing degradable/bioeliminable networks designed for use in health applications. The strategies used to develop such networks based on reversible covalent or physical cross-linking or their combination via dual/multi-cross-linking approaches are analyzed in detail. The key parameters of these hydrogels and elastomers, such as mechanical properties, repair and degradation times, and healing efficiencies, are critically considered in terms of their suitabilities in biomedical applications. Finally, their current and prospective uses as biomaterials in the fields of tissue engineering, drug/cell delivery, and medical devices are presented, followed by the remaining challenges faced to ensure the further success of degradable self-healable networks.

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Poly(aspartic acid) based self-healing hydrogels with antibacterial and light-emitting properties for wound repair

Cited by 21 publications

References 67 publications

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Recent progress of antibacterial hydrogels in wound dressings

Degradable Self‐healable Networks for Use in Biomedical Applications

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