Hydrogels
with inherent antibacterial ability are a focus in soft
tissue repair. Herein, a series of antibacterial hydrogels were fabricated
by quaternized N-[3-(dimethylamino)propyl] methacrylamide
(quaternized P(DMAPMA-DMA-DAA)) bearing copolymers with dithiodipropionic
acid dihydrazide (DTDPH) as cross-linker. The hydrogels presented
efficient self-healing capability as well as a pH and redox-triggered
gel–sol–gel transition property that is based on the
dynamic acylhydrazone bond and disulfide linkage. Furthermore, the
hydrogels showed good antibacterial activity, biocompatibility, degradability,
and sustained release ability. More importantly, the in vivo experiments
demonstrated that the hydrogels loaded with mouse epidermal growth
factor (mEGF) significantly accelerated wound closure by preventing
bacterial infection and promoting cutaneous regeneration in the wound
model. The antibacterial hydrogels with self-healing behavior hold
great potential in wound treatment.
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