Poly(d,l-lactide)/polyethylene glycol micro/nanofiber mats as paclitaxel-eluting carriers: preparation and characterization of fibers, in vitro drug release, antiangiogenic activity and tumor recurrence prevention

Hobzová, Radka; Hampejsová, Zuzana; Černá, Tereza; Hraběta, Jan; Venclíková, Kristýna; Jedelská, Jarmila; Bakowsky, Udo; Bosáková, Zuzana; Lhotka, Miloslav; Vaculín, Šimon; Franěk, Miloslav; Steinhart, Miloš; Kovářová, Jana; Michálek, Jiřı́; Širc, Jakub

doi:10.1016/j.msec.2019.01.046

Cited by 27 publications

(10 citation statements)

References 59 publications

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“…In the literature, it has been reported that PTX is miscible with the amorphous domains of PLLA, in consequence softening the polymer matrix, leading to a decrease in T g [69]. Furthermore, this also leads to the formation of an exothermic peak (T c ) , which increases with increasing PTX amount, as the incorporated PTX decelerates polymer recrystallization [31,70]. Liggins and Burt explained it in a way that hydrogen bonding between PLLA and PTX lead to accumulation of PTX in the amorphous regions and therefore in a reduced rate of polymer chain diffusion and thus slowed crystallization [71].…”

Section: Discussionmentioning

confidence: 99%

Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

et al. 2021

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Local drug delivery has become indispensable in biomedical engineering with stents being ideal carrier platforms. While local drug release is superior to systemic administration in many fields, the incorporation of drugs into polymers may influence the physico-chemical properties of said matrix. This is of particular relevance as minimally invasive implantation is frequently accompanied by mechanical stresses on the implant and coating. Thus, drug incorporation into polymers may result in a susceptibility to potentially life-threatening implant failure. We investigated spray-coated poly-l-lactide (PLLA)/drug blends using thermal measurements (DSC) and tensile tests to determine the influence of selected drugs, namely sirolimus, paclitaxel, dexamethasone, and cyclosporine A, on the physico-chemical properties of the polymer. For all drugs and PLLA/drug ratios, an increase in tensile strength was observed. As for sirolimus and dexamethasone, PLLA/drug mixed phase systems were identified by shifted drug melting peaks at 200 °C and 240 °C, respectively, whereas paclitaxel and dexamethasone led to cold crystallization. Cyclosporine A did not affect matrix thermal properties. Altogether, our data provide a contribution towards an understanding of the complex interaction between PLLA and different drugs. Our results hold implications regarding the necessity of target-oriented thermal treatment to ensure the shelf life and performance of stent coatings.

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Section: Discussionmentioning

confidence: 99%

Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

et al. 2021

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“…The results revealed that fibers containing PEG discharged more PTX and had a longer release duration than fibers containing PTX but lacking PEG. This initial rate rise culminated in an average increase in Paclitaxel drug release in the accumulated model [74] .…”

Section: Electrospun Nanofibrous Drug Delivery System For Chemotherapymentioning

confidence: 99%

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

Mateti

Aswath

Vatti

et al. 2021

Biotechnology Reports

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Highlights The life-threatening side effects of cancer treatment are addressed using nano-formulations and combinational therapy. Herbal drugs displayed potency in curing cancer using a nanofiber based device. Allopathic anti-cancer drugs can be delivered at a targeted site using a nanofiber based drug carrier which improves bioavailability to a great extent. A combination of an herbal and allopathic anticancer drug could be a possible life-saving union to cure cancer.

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“…To evaluate the long-term biocompatibility of bolalipid aerogels, PC-C32-PC or Me 2 PE-C32-Me 2 PE aerogels were carefully placed on the CAM surface at EDD 9. A daily analysis of the samples, vessel formation and health of the CAM surface was carried out at 13-fold magnification using a stereomicroscope [48,49]. Pictures were taken as described above.…”

Section: Methodsmentioning

confidence: 99%

The Use of Artificial Gel Forming Bolalipids as Novel Formulations in Antimicrobial and Antifungal Therapy

et al. 2019

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The alarming growth of multi-drug resistant bacteria has led to a quest for alternative antibacterial therapeutics. One strategy to circumvent the already existing resistance is the use of photodynamic therapy. Antimicrobial photodynamic therapy (aPDT) involves the use of non-toxic photosensitizers in combination with light and in situ oxygen to generate toxic radical species within the microbial environment which circumvents the resistance building mechanism of the bacteria. Hydrogels are used ubiquitously in the biological and pharmaceutical fields, e.g., for wound dressing material or as drug delivery systems. Hydrogels formed by water-insoluble low-molecular weight gelators may potentially provide the much-needed benefits for these applications. Bolalipids are a superior example of such gelators. In the present work, two artificial bolalipids were used, namely PC-C32-PC and Me2PE-C32-Me2PE, which self-assemble in water into long and flexible nanofibers leading to a gelation of the surrounding solvent. The aim of the study was to create stable hydrogel formulations of both bolalipids and to investigate their applicability as a novel material for drug delivery systems. Furthermore, methylene blue—a well-known photosensitizer—was incorporated into the hydrogels in order to investigate the aPDT for the treatment of skin and mucosal infections using a custom designed LED device.

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Poly(d,l-lactide)/polyethylene glycol micro/nanofiber mats as paclitaxel-eluting carriers: preparation and characterization of fibers, in vitro drug release, antiangiogenic activity and tumor recurrence prevention

Cited by 27 publications

References 59 publications

Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

Influence of Drug Incorporation on the Physico-Chemical Properties of Poly(l-Lactide) Implant Coating Matrices—A Systematic Study

A review on allopathic and herbal nanofibrous drug delivery vehicles for cancer treatments

The Use of Artificial Gel Forming Bolalipids as Novel Formulations in Antimicrobial and Antifungal Therapy

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