Poly ɛ-caprolactone/nanostarch composite nanofibrous wound dressing with antibacterial property and pH stimulus drug release

Abstract

Chronic wound infections pose a major threat in wound care management. Recently, many functional materials have been introduced, to fabricate wound dressings. These wound dressing materials not only cover the wound but also facilitate its healing process. In this study, a novel nanostarch (NS) laden composite nanofibrous membrane of PCL was developed for wound dressing. Electrospun membrane loaded with 25 wt% NS (25NS@PCL), showed an average fiber diameter of 175 ± 37 nm with enhanced hydrophilicity, water uptake, water permeability, and biodegradation. The membrane exhibited good blood compatibility along with lower coagulation properties and high cell proliferation. Furthermore, this membrane displayed pH stimuli drug (gentamicin) releasing behavior and diffusion-controlled release kinetics. The drug-loaded 25NS@PCL membrane imparted antibacterial potency for a prolonged time against both Escherichia Coli and Staphylococcus aureus. These results confirmed that the 25NS@PCL membrane can be a promising candidate for the development of pHresponsive transdermal drug delivery material.

pH-Responsive wound dressings: advances and prospects

“…pH-Responsive hydrogels are the main type of pH-responsive wound dressings. Other advanced pH-responsive materials include nanofibers, 96 composite films, 97 nanoparticle clusters, 98 and microneedles, 99 each with unique characteristics and advantages for wound healing. In this section, the pH-responsive mechanisms and properties of other pH-responsive materials are discussed, and the relevant information is summarized in Table 2.…”

“…In addition, 15 days of long-acting antimicrobial activity demonstrated an excellent controlled release effect. 96 Electrospinning technology could realize intelligent drug delivery by adjusting of composition ratio. Liu et al develop CS/ PVA/GO nanofibrous membranes with strong antibacterial activity and sustained-release properties.…”

Natural vs Synthetic Polymers: How Do They Communicate with Cells for Skin Regeneration—A Review

“…However, it has been reported that this can be overcome by using extracted cellulose from different plants from Ecuador [69]. Cellulose has been widely used to produce polymers for tissue engineering applications and skin regeneration, including but not limited to hydrogels [69][70][71][72], films [73], nanofibrous wound dressing [74], non-woven composites [75], 3D-printed scaffolds [76], and fiber bats [77] among others.…”

Current State and Future Perspectives of Starch Derivatives and Their Blends as Antimicrobial Materials

“…Antibacterial poly ɛ‐caprolactone/nanostarch composite nanofibrous wound dressing with pH stimulation drug release was reported by Reshmi et al. [ 182 ] The membrane was shown to have strong cell proliferation, low coagulation characteristics, and good blood compatibility. This membrane also exhibited pH stimuli drug (gentamicin) releasing activity as well as diffusion‐controlled release kinetics.…”