(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

Hagan, M.O.; Hayee, Bu’Hussain; Rodríguez-Mateos, Ana

doi:10.3390/molecules26071843

Cited by 24 publications

(16 citation statements)

References 110 publications

(194 reference statements)

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“…Abundant amounts of vegetables and fruits is a property of MD, which are not only rich in dietary fibers and micronutrients, but also the source of biophenols. Pomegranate, curcumin, bilberry anthocyanin, apple, mango, naringenin, ginger, and green tea showed potential therapeutic effects for IBD in some interventional studies [ 127 , 128 ]. In addition, olive oil is a special component in MD compared with other diet patterns and accounts for the majority of the antioxidant and anti-inflammatory activity of MD [ 128 ].…”

Section: Dietary Strategies Alleviating Ibdmentioning

confidence: 99%

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Yan

Lei

et al. 2022

Nutrients

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Inflammatory bowel disease (IBD) is a result of a complex interplay between genes, host immune response, gut microbiota, and environmental factors. As one of the crucial environmental factors, diet plays a pivotal role in the modulation of gut microbiota community and the development of IBD. In this review, we present an overview of dietary patterns involved in the pathogenesis and management of IBD, and analyzed the associated gut microbial alterations. A Westernized diet rich in protein, fats and refined carbohydrates tends to cause dysbiosis and promote IBD progression. Some dietary patterns have been found effective in obtaining IBD clinical remission, including Crohn’s Disease Exclusion Diet (CDED), Mediterranean diet (MD), Anti-Inflammatory Diet (AID), the low-“Fermentable Oligo-, Di-, Mono-saccharides and Polyols” (FODMAP) diet, Specific Carbohydrate Diet (SCD), and plant-based diet, etc. Overall, many researchers have reported the role of diet in regulating gut microbiota and the IBD disease course. However, more prospective studies are required to achieve consistent and solid conclusions in the future. This review provides some recommendations for studies exploring novel and potential dietary strategies that prevent IBD.

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Section: Dietary Strategies Alleviating Ibdmentioning

confidence: 99%

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Yan

Lei

et al. 2022

Nutrients

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“…Further, several studies have investigated the potential direct therapeutic benefits of PCs in IBD. Although current data on PCs for treating IBD do not exhibit consistent effectiveness [33], several studies using curcumin for both UC and CD have generated promising results [23,34]. Several natural PCs have been known to exert beneficial effects against various diseases, in addition to their intrinsic antioxidant and scavenging properties [35,36].…”

Section: Discussionmentioning

confidence: 99%

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

et al. 2022

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Phenolic compounds (PCs) present in foods are associated with a decreased risk of developing inflammatory diseases. The aim of this study was to extract and characterize PCs from craft beer powder and evaluate their potential benefits in an experimental model of inflammatory bowel disease (IBD). PCs were extracted and quantified from pure beer samples. BALB/c mice received either the beer phenolic extract (BPE) or beer powder fortified with phenolic extract (BPFPE) of PCs daily for 20 days by gavage. Colon samples were collected for histopathological and immunohistochemical analyses. Dextran sodium sulfate (DSS)-induced mice lost more weight, had reduced colon length, and developed more inflammatory changes compared with DSS-induced mice treated with either BPE or BPFPE. In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-κB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated. Pretreatment with the phenolic extract and BPFPE remarkably attenuated DSS-induced colitis. The protective effect of PCs supports further investigation and development of therapies for human IBD.

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“…In clinical studies investigating the efficacy of polyphenols in IBD patients, promising results of polyphenols and phenolic compounds such as anthocyanin, resveratrol, epigallocatechin-3-gallate including foods rich in polyphenols (e.g., red wine, green tea and ginger) on various markers of inflammation, IBD-related symptoms and measures of disease activity have also been reported, although the number of studies is limited ( 119 ).…”

Section: Plant-derived Phytochemicals and Inflammatory Bowel Diseasementioning

confidence: 99%

“…Despite the limited number of intervention studies investigating the efficacy of polyphenols in IBD patients, particular interest has been devoted to the hydrophobic polyphenolic compound curcumin, and to date, curcumin may be the most investigated polyphenol in IBD patients due to its potentially clinical therapeutic anti-inflammatory and immunoregulatory effects ( 119 ).…”

Section: Plant-derived Phytochemicals and Inflammatory Bowel Diseasementioning

confidence: 99%

Reducing Disease Activity of Inflammatory Bowel Disease by Consumption of Plant-Based Foods and Nutrients

et al. 2021

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Inflammatory bowel disease is a chronic and recurring inflammatory condition of the gastrointestinal tract encompassing ulcerative colitis and Crohn's disease. Although the pathogenesis of inflammatory bowel disease remains to be fully elucidated, environmental factors such as diet are believed to play a pivotal role in the onset and management of inflammatory bowel disease. Diet is thought to play an essential role in intestinal inflammation due to its regulatory effects on the microbiota, gut immune system, and epithelial barrier function. Although the evidence remains insufficient to draw firm conclusions on the role of specific dietary components in gastrointestinal diseases, studies have suggested that a Western diet with high intakes of total fats, omega-6 fatty acids, and meat have been associated with intestinal inflammation and relapse of inflammatory bowel disease. In contrast to a Western diet, plant-based diets often result in a reduced intake of total fats and meats and an increased intake of plant fibers which may contribute to reduced intestinal inflammation. This review critically examines the influence of plant-based dietary components on the clinical disease course of inflammatory bowel disease. Furthermore, this review discusses the benefits and possible limitations of plant-derived dietary components in the treatment of inflammatory bowel disease while addressing the principal type of disease and the anatomic site of inflammation within the gastrointestinal tract. Finally, this review points out important directions for future research on the role of diet in inflammatory bowel disease. A better understanding of the role of diet and intestinal inflammation may pave the way for novel dietary interventions and specific foods- or food supplements, which can support the treatment of inflammatory bowel disease.

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(Poly)phenols in Inflammatory Bowel Disease and Irritable Bowel Syndrome: A Review

Cited by 24 publications

References 110 publications

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Dietary Patterns and Gut Microbiota Changes in Inflammatory Bowel Disease: Current Insights and Future Challenges

Bioactive Compounds from Pale Ale Beer Powder Attenuate Experimental Colitis in BALB/c Mice

Reducing Disease Activity of Inflammatory Bowel Disease by Consumption of Plant-Based Foods and Nutrients

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