Polyacrylamide hydrogel pulmonary embolism—A fatal consequence of an illegal cosmetic vaginal tightening procedure: A case report

Duan, Yijie; Zhang, Lin; Li, Shangxun; Yang, Yi; Xing, Jiali; Li, Wenhe; Wang, Xinmei; Zhou, Yiwu

doi:10.1016/j.forsciint.2014.02.021

Cited by 19 publications

(12 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 15 – 17 This process is somewhat similar to the development of embolism caused by buttock augmentation or penis enlargement with fat grafting. 9 , 18 , 19 Abundant veins are present in the relatively narrow local space surrounding the vagina. These veins meander and expand, forming a dense venous plexus, and eventually merge into the internal iliac vein and then into the inferior vena cava.…”

Section: Discussionmentioning

confidence: 99%

Severe fat embolism after autologous fat grafting in vaginal tightening and breast augmentation surgery

Wang

Huang

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Autologous fat grafting has become increasingly popular in the field of aesthetic surgery because of its biocompatibility and low donor site morbidity. However, some fatal complications may occur following the surgery. We herein describe a woman who developed severe fat embolism after autologous fat grafting for vaginal tightening and breast augmentation surgery. The patient developed symptoms of dyspnea and hypoxemia. Computed tomography pulmonary angiography showed multiple filling defects in the bilateral pulmonary arteries and branches with a maximum size of approximately 1.2 × 0.7 cm. Fat embolism was assumed to have occurred by injection of fat directly into the vessels around the vagina. Further research is needed to elucidate the anatomical mechanism underlying this phenomenon.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe fat embolism after autologous fat grafting in vaginal tightening and breast augmentation surgery

Wang

Huang

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

show abstract

“…However, nonthrombotic pulmonary embolism (NTPE) secondary to PAAG injection is a rare clinicopathologic entity. To our research, there is only one case of PAAG-induced NTPE in the literature [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Nonthrombotic Pulmonary Embolism: A Potential Complication of Polyacrylamide Hydrogel Cosmetic Injection

Inayat

Cheema

Virk

et al. 2016

Case Reports in Medicine

View full text Add to dashboard Cite

Context. Polyacrylamide hydrogel (PAAG) has gained importance as a synthetic soft tissue filling agent. It has been commonly employed by physicians in Europe for facial contouring and soft tissue augmentation. Previously, PAAG is considered nontoxic and well tolerated with a few mild procedural complications. Case Presentation. A 26-year-old female was hospitalized for dry cough, worsening dyspnea, and chest discomfort after 3 hours of multiple PAAG injections in buttocks. The patient's condition deteriorated and rapidly advanced to acute respiratory failure. Therein, the diagnosis of nonthrombotic pulmonary embolism (NTPE) was established on standard set of investigations. She was intubated; corticosteroid and empiric antibiotic therapy was initiated resulting in improvement of her condition. Subsequently, extubation was done, and she was discharged from the hospital after an uneventful recovery. On 1-month follow-up, the patient had no previous symptoms. Conclusion. This report implicates clinicians to maintain a high index of suspicion for NTPE in patients presenting with respiratory symptoms following PAAG usage.

show abstract

“…In personal care products, polyacrylamides have been used as foam builders in shampoos and as lubricants and emollients in cosmetics, soaps, and lotions. In the manufacture of polyacrylamides, a small amount of the acrylamide or derivative monomers may be present in the final polyacrylamides products (Andersen, ; Duan et al, ; Exon, ; Friedman, ; Nussinovitch, ; Rabiee et al, ; Shipp et al, ; Wang et al ).…”

Section: Introductionmentioning

confidence: 99%

A study of digital image analysis on the acrylamide derivative monomers induced apoptosis in rat cerebrum

Saraydın

İnan

2020

Microscopy Res & Technique

View full text Add to dashboard Cite

Nowadays, apoptosis is mostly evaluated visually in histological studies. By using the quantitative digital image analysis, this study aimed to investigate the effect of acrylamide‐based monomers (acrylamide [AAm], methacrylamide [MAAm], N‐isopropylacrylamide [NIPAm]) on the cerebrum tissues in rats, which are the most common water‐soluble monomers in the production of polymeric hydrogels used as biomaterials. The Wistar albino rats weighing ~220–240 g were divided into control and three test groups. The control group received 1 mL of saline, and the test groups received 1 mL of aqueous 50 mg/kg/day intramuscular injection of AAm, MAAm, and NIPAm, respectively. At the end of the experiments, brain tissues of all rats euthanized by intramuscular injection of sodium pentobarbital were removed. Terminal deoxynucleotide transferase dUTP nick and labeling (TUNEL) method was applied to brain tissue sections. The monomers have been shown to cause apoptosis due to oxidative stress in cerebrum tissue. Based on apoptosis by tunneling method, quantitative digital image analysis of cell fragments was performed with Olympus cellSens Dimension 1.15 software, and the number, total count area, selected area, average area, and ROI% values of the fragments were found. In addition, the total area and ROI% values of the fragments increased linearly with increasing the molar mass of monomers from the digital image analysis data. Quantitative digital image analysis can facilitate the monitoring of apoptosis caused by the oxidative stress of monomers used in the production of the biomaterials.

show abstract

Polyacrylamide hydrogel pulmonary embolism—A fatal consequence of an illegal cosmetic vaginal tightening procedure: A case report

Cited by 19 publications

References 23 publications

Severe fat embolism after autologous fat grafting in vaginal tightening and breast augmentation surgery

Severe fat embolism after autologous fat grafting in vaginal tightening and breast augmentation surgery

Nonthrombotic Pulmonary Embolism: A Potential Complication of Polyacrylamide Hydrogel Cosmetic Injection

A study of digital image analysis on the acrylamide derivative monomers induced apoptosis in rat cerebrum

Contact Info

Product

Resources

About