Polyanetholsulfosaures Natrium, ein neues synthetisches Mittel zur Hemmung der Blutgerinnung

Demole, V.; Reinert, M

doi:10.1007/bf01861233

Cited by 44 publications

(2 citation statements)

References 3 publications

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“…Liquoid, the polyanetboi sulphonic acid, is a polydisperse though predominantly high molecular weight polymer of alpha-methoxystyrene. Its sodium salt is known to inhibit blood coagulation [8], to possess anti-complement activity [10]. and to 507 activate monocytes by binding lo membranebound Clq [26].…”

mentioning

confidence: 99%

Selective Inhibition of Human Natural Killing and Antibody‐Dependent Cellular Cytotoxicity by a Polyanion

Roellinger¹,

Loos²,

Leibold³

1987

Scand J Immunol

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A high molecular polyanion, Liquoid, was found to inhibit at nontoxic concentrations (12-50 micrograms/ml) the natural killing (NK) and the antibody-dependent cellular cytotoxic (ADCC) activity of human peripheral blood mononuclear cells selectively. Whereas NK of the K 562 target cell was slightly or not at all affected, the spontaneous lysis of PDe-B-1, an EBV-transformed B-cell line, was strongly inhibited or even completely abolished. ADCC activity could only be inhibited by Liquoid if the target cells were mycoplasma-free, while the polyanion had no effect when mycoplasma-contaminated target cells were used. Liquoid did not alter the target binding capacity of the NK effector cells and did not activate monocytes or induce other suppressive cells. Alpha interferon, but neither beta nor gamma interferon, was able to neutralize the NK reduction. These results suggest that Liquoid inhibits a target cell-related, selective process in the post-binding stage of NK cell lysis.

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confidence: 99%

Selective Inhibition of Human Natural Killing and Antibody‐Dependent Cellular Cytotoxicity by a Polyanion

Roellinger¹,

Loos²,

Leibold³

1987

Scand J Immunol

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“…Sodium polyanetholsulfonate (SPS) is an anticomplementary and antiphagocytic synthetic anticoagulant (1, 3,16). Because of these properties, SPS has found widespread use in blood cultures (12,15).…”

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confidence: 99%

Anticomplementary, Anticoagulatory, and Serum-Protein Precipitating Activity of Sodium Polyanetholsulfonate

Traub¹,

Lowrance²

1970

Applied Microbiology

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ment-mediated hemolysis of 1:10 diluted fresh guinea pig and human serum; at least twice as much SPS was required to reduce complement activity in 1: 2 diluted human serum. The coagulation of 90 and 20% human blood was inhibited by 250 and 125 Ag of SPS per ml, respectively. When added to fresh human serum, SPS precipitated beta iC-globulin (C3), C4, beta lipoproteins, immunoglobulin IgG, IgM, and IgA, though incompletely.

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Quantitative Studies on Antithrombin

Wilson¹

1942

Arch Intern Med

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Polyanetholsulfosaures Natrium, ein neues synthetisches Mittel zur Hemmung der Blutgerinnung

Cited by 44 publications

References 3 publications

Selective Inhibition of Human Natural Killing and Antibody‐Dependent Cellular Cytotoxicity by a Polyanion

Selective Inhibition of Human Natural Killing and Antibody‐Dependent Cellular Cytotoxicity by a Polyanion

Anticomplementary, Anticoagulatory, and Serum-Protein Precipitating Activity of Sodium Polyanetholsulfonate

Quantitative Studies on Antithrombin

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