Polybutylene succinate adipate/starch blends: A morphological study for the design of controlled release films

Khalil, Fadi; Galland, Sophie; Cottaz, Amandine; Joly, Catherine; Degraeve, Pascal

doi:10.1016/j.carbpol.2014.02.062

Cited by 33 publications

(19 citation statements)

References 23 publications

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“…The roughness decreased as the PLA concentration decreased due phase inversion, in which TPS was the continuous phase. CLM was also used to evaluate the surface roughness of the starch films treated by plasma [1] and to identify the blend compositions that correspond to the beginning of partial continuity until total continuity of the poly(butylene succinate-co-adipate) (PBSA) and TPS phases [32] .…”

Section: Morphological Characterizationmentioning

confidence: 99%

Poly(lactic acid)/thermoplastic starch sheets: effect of adipate esters on the morphological, mechanical and barrier properties

et al. 2016

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SbstractBlends of poly(lactic acid) (PLA) and thermoplastic starch (TPS) plasticized with adipate esters (diisodecyl adipate and diethyl adipate) having different molecular weight were used to produce sheets. The calendering-extrusion process at a pilot scale was used, and the mechanical, barrier, and morphological characterization of the obtained materials were performed. The increase in the TPS content affected the mechanical properties of the sheets by increasing the elongation and decreasing the rigidity. TPS conferred a more hydrophilic character to the sheets, as observed from the water vapor permeability results. The sheets plasticized with diisodecyl adipate (DIA), having a higher molecular weight, had better mechanical and barrier properties than diethyl adipate (DEA) plasticized sheets, indicating that DIA was more effective as plasticizer. Micrographs obtained by confocal laser microscopy and scanning electron microscopy showed different morphologies when different proportions of PLA and TPS were used (dispersed or co-continuous structures), which were strongly associated with the mechanical and barrier properties.

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Section: Morphological Characterizationmentioning

confidence: 99%

Poly(lactic acid)/thermoplastic starch sheets: effect of adipate esters on the morphological, mechanical and barrier properties

et al. 2016

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“…Among these aliphatic polyesters, poly(butylene succinate) (PBS) is a biodegradable and biocompatible linear aliphatic polyester, which is synthesized by polycondensation of 1,4‐butanediol with succinic acid, and has relatively low production cost and properties similar to those of polyolefins . Furthermore, PBS is a synthetic polymer which is expected to be ‘all green’ in the future and can be obtained by bacterial fermentation . However, as research moves along, it has been found that PBS is often challenged by its highly hydrophobic architecture, insufficient biocompatibility, slow rate of degradation and in particular absence of reactive centers for the covalent immobilization of bioactive molecules such as drugs, peptides and proteins .…”

Section: Introductionmentioning

confidence: 99%

“…No positively charged group or polymer has been used to modify PBS. As for the applications of PBS‐based copolymers as drug carriers, there are some studies reported of microcapsules, microspheres, scaffolds or films of PBS as drug carriers . Few studies of micelles with PBS as the hydrophobic core have been reported.…”

Section: Introductionmentioning

confidence: 99%

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Zhao

Guo

et al. 2018

Polymer International

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Copolymers of poly[2‐(dimethylamino)ethyl methacrylate]–poly(butylene succinate)–poly[2‐(dimethylamino)ethyl methacrylate] (PDMAEMA–PBS–PDMAEMA, PDBD) were synthesized through a chain‐extension reaction. The thermal properties characterized using differential scanning calorimetry showed that the introduction of PDMAEMA chains slightly decreased the melting temperature of PBS. The water contact angle of PDBD copolymer films with media of various pH decreased with a decrease of pH. This should be ascribed to the conformational transition of PDMAEMA blocks from a compact coil to an expanding shape in accordance with the variation of the pH of the surroundings. The results of dynamic light scattering and scanning electron microscopy revealed that PDBD copolymers could form spherical micelles with small particle size and narrow particle size distribution. Furthermore, drug loading (loading content, ca 10%; encapsulation efficiency, ca 60%) and release experiments were conducted using doxorubicin as a hydrophobic model drug. The results of release experiments of copolymer nanomicelles showed that these micelles had pH‐responsive properties. © 2018 Society of Chemical Industry

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“…Furthermore, these two monomers are accessible from renewable resources; therefore it is considered as a promising polymer for development. To our knowledge, some work has been reported about microcapsules, microspheres, scaffolds or films of PBS as drug carriers . However, few studies of micelles with PBS as the hydrophobic core have been reported.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

Zhang

Bao

et al. 2017

Polymer International

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A series of copolymers of poly(2‐methacryloyloxyethyl phosphorylcholine)‐b‐poly(butylene succinate)‐b‐poly(2‐methacryloyloxyethyl phosphorylcholine) (PMPC‐b‐PBS‐b‐PMPC) were synthesized by atom transfer radical polymerization. The structure of the polymers was characterized by 1H NMR and infrared spectroscopy, and their thermal properties were described using TGA and DSC. In aqueous solutions, the PMPC‐b‐PBS‐b‐PMPC could form micelles with sizes ranging from 108 to 170 nm. In vitro release studies showed that acidic media and a longer PMPC chain benefited doxorubicin (DOX) release. 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) assays indicated that the micelles had low cytotoxicity to HeLa and L929 cells. DOX‐loaded micelles exhibited high cytotoxicity to HeLa cells. Flow cytometry results demonstrated that DOX‐loaded micelles could be internalized by HeLa cells. The in vitro phagocytosis results showed 3.9‐fold and 5.5‐fold reductions compared with poly(lactic acid) (PLA) nanoparticles and PDS55 micelles. These results demonstrate that PMPC‐b‐PBS‐b‐PMPC block copolymer micelles have great promise for cancer therapy. © 2017 Society of Chemical Industry

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Polybutylene succinate adipate/starch blends: A morphological study for the design of controlled release films

Cited by 33 publications

References 23 publications

Poly(lactic acid)/thermoplastic starch sheets: effect of adipate esters on the morphological, mechanical and barrier properties

Poly(lactic acid)/thermoplastic starch sheets: effect of adipate esters on the morphological, mechanical and barrier properties

Preparation of poly(butylene succinate)‐poly[2‐(dimethylamino)ethyl methacrylate] copolymers and their applications as carriers for drug delivery

Fabrication of micelles from poly(butylene succinate) and poly(2‐methacryloyloxyethyl phosphorylcholine) copolymers as a potential drug carrier

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