Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/ MyD88/NF-κB pathway

Zou, Meiling; Yang, Wenlong; Niu, Liangjie; Sun, Yingfei; Luo, Ronglong; Wang, Yingjie; Peng, Xiuli

doi:10.1016/j.micpath.2020.104552

Cited by 23 publications

(13 citation statements)

References 44 publications

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“…Second, PD treatment (15, 30, and 60 µg/mL) was shown to significantly suppress the expression of IL-6, IL-1β, and TNF-α induced by MG in chicken embryo fibroblast (DF-1) cells. Furthermore, the MG-induced levels of TLR6, MyD88, and NF-κB were also significantly decreased by PD treatment, which restrained the MG-induced NF-κB-p65 nuclear translocation [292].…”

Section: Salmonellamentioning

confidence: 90%

“…Interestingly, baicalin was reported to restore the mRNA expression of mitochondrial dynamics-related genes and maintain the balance between mitochondrial inner and outer membranes, as well as upregulate the Nrf2/HO-1 pathway and suppress the NF-κB pathway in the spleen of MG-infected chicken [294]. Similar protective effects of baicalin [295] and polydatin, a resveratrol glycoside isolated from Polygonum cuspidatum [292], against MG-induced inflammation injury in chicken embryonic lung were associated with their inhibition of the TLR6/MyD88/NF-κB pathway.…”

Section: Salmonellamentioning

confidence: 90%

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Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

2021

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Redox biology is a very quickly developing area of modern biological sciences, and roles of redox homeostasis in health and disease have recently received tremendous attention. There are a range of redox pairs in the cells/tissues responsible for redox homeostasis maintenance/regulation. In general, all redox elements are interconnected and regulated by various means, including antioxidant and vitagene networks. The redox status is responsible for maintenance of cell signaling and cell stress adaptation. Physiological roles of redox homeostasis maintenance in avian species, including poultry, have received limited attention and are poorly characterized. However, for the last 5 years, this topic attracted much attention, and a range of publications covered some related aspects. In fact, transcription factor Nrf2 was shown to be a master regulator of antioxidant defenses via activation of various vitagenes and other protective molecules to maintain redox homeostasis in cells/tissues. It was shown that Nrf2 is closely related to another transcription factor, namely, NF-κB, responsible for control of inflammation; however, its roles in poultry have not yet been characterized. Therefore, the aim of this review is to describe a current view on NF-κB functioning in poultry with a specific emphasis to its nutritional modulation under various stress conditions. In particular, on the one hand, it has been shown that, in many stress conditions in poultry, NF-κB activation can lead to increased synthesis of proinflammatory cytokines leading to systemic inflammation. On the other hand, there are a range of nutrients/supplements that can downregulate NF-κB and decrease the negative consequences of stress-related disturbances in redox homeostasis. In general, vitagene–NF-κB interactions in relation to redox balance homeostasis, immunity, and gut health in poultry production await further research.

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Section: Salmonellamentioning

confidence: 90%

Section: Salmonellamentioning

confidence: 90%

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

2021

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“…Resveratrol treatment also reduced the expression of the inflammatory factors, glycation end product receptor (RAGE), NF-кB (P65) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) and improved the renal pathological structure [26]. In addition, as the natural precursor of resveratrol, polydatin (a resveratrol glycoside isolated from Polygonum cuspidatum) significantly downregulated IL-6, IL-1β, and TNF-α expression induced by Mycoplasma gallisepticum both in vivo and in vitro, suggested that polydatin also has anti-inflammatory effect [27].…”

Section: The Anti-inflammatory Activity Of Resveratrolmentioning

confidence: 99%

Anti-Inflammatory Action and Mechanisms of Resveratrol

et al. 2021

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Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms and the immunomodulatory function of resveratrol both in vivo and in vitro. The data acquired from those studies are discussed.

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“…Moreover, Polydatin reduced ROS and attenuated oxidative stress through the Keap1/Nrf2/ARE pathway in Graves' orbitopathy [5]. Polydatin suppressed the inflammatory cytokines secretion, and restrained the TLR6/MyD88/NF-kB pathway by Mycoplasma gallisepticum infection (a main cause of chronic respiratory disease) in vivo and in vitro [25]. Another study showed that Polydatin weakens cadmium-induced oxidative stress through inducing SOD activity and regulating mitochondrial function in Musca domestica larvae [26].…”

Section: Polydatinmentioning

confidence: 98%

Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin

Doustimotlagh

Eftekhari

2021

Clinical Nutrition ESPEN

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The COVID-19 pandemic as the largest global public health crisis is now considered as an emergency at the World Health Organization (WHO). As there is no specific therapy for SARS-CoV-2 infection at present and also because of the long time it takes to discover a new drug and the urgent need to respond urgently to a pandemic infection. Perhaps the best way right now is to find an FDA-approved drug to treat this infection. Oxidative stress and inflammation play a vital role in the progression of tissue injury in COVID-19 patients; furthermore, the G6PD activation is related to increased oxidative inflammation in acute pulmonary injury. In this regard, we propose a new insight that may be a good strategy for this urgency. Exploiting G6PD through inhibiting G6PD activity by modifying redox balance, metabolic switching and proteineprotein interactions can be proposed as a new approach to improving patients in severe stage of COVID 19 through various mechanisms. Polydatin is isolated from many plants such as Polygonum, peanuts, grapes, red wines and many daily diets that can be used in severe stage of COVID-19 as a G6PD inhibitor. Furthermore, polydatin possesses various biological activities such as antiinflammatory, antioxidant, immunoregulatory, nephroprotective, hepatoprotective, anti-arrhythmic and anti-tumor. Our hypothesis is that the consumption of antioxidants such as Polydatin (a glucoside of resveratrol) as a complementary therapeutic approach may be effective in reducing oxidative stress and inflammation in patients with COVID-19.

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Polydatin attenuates Mycoplasma gallisepticum (HS strain)-induced inflammation injury via inhibiting the TLR6/ MyD88/NF-κB pathway

Cited by 23 publications

References 44 publications

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Redox Homeostasis in Poultry: Regulatory Roles of NF-κB

Anti-Inflammatory Action and Mechanisms of Resveratrol

Glucose-6-phosphate dehydrogenase inhibitor for treatment of severe COVID-19: Polydatin

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