Polyhydroquinolines: 1-sulfopyridinium chloride catalyzed an efficient one-pot multicomponent synthesis via Hantzsch condensation under solvent-free conditions

Facile Synthesis of new 7-morpholino-6-(Aryl-1,3,4-oxadiazol)-1,8-naphthyridines and, evaluation of Antimicrobial and molecular Docking studies

“…It has the long apprehended ambition of the scientists and chemist is that nd the new paths via a green and sustainable methodology to prepare the bioactive molecules. In view of the importance of designed 1,8-naphthyridine derivatives in medicinal chemistry, Keeping these features and importance in mind, and as part of our continued ongoing research in the area of 1,8-naphthyridines and recently sakram et all stated [16][17][18][19] motivated by group and prepared these molecules here we report a 7-morpholino-6-(5-Aryl-1,3,4-oxadiazol)-1,8-naphthyridine in an pro cient fashion (Scheme 1). To the best of our awareness, no method reported in the literature and these molecules synthesis via using environmentally friendly catalyst and biological studies.…”

Eco-friendly green construction of 4-Aryl-tetrazolo-[1,5-a][1,8]naphthyridine scaffolds and their in vitro anti-microbial and molecular modeling studies

“…[12][13][14][15][16] In prolongation, of our foregoing studies on the development of green methodologies and biologically active compounds. [17][18][19][20][21] We report here in a facile and convenient synthetic strategy for the preparation of 4-aryl tetrazolo[1,5-a][1,8]naphthyridine derivatives in the presence of simple glacial acetic acid formed high yield and these compounds showed interesting antimicrobial activity.…”

“…The target protein le was make by eliminating the structural water molecule, hetero atoms and co-factors by leaving only the residues associated with protein by using ADS tool was used to prepare target protein le addition of polar hydrogen's to the macromolecule. The molecular docking was performed using ligand t module and obtained results were scrutinized based on number of H-bonds and highest dock score by SS Viewer Shyam et al 201319 . The molecular modeling results showed that…”

Design, and Green synthetic approach of the Aryl-tetrazolo-[1,5-a][1,8]naphthyridine Molecules and their in vitro anti-microbial activity and In silico molecular modeling studies

“…The heating is instantaneous and extremely speci c. The pro t of microwave-supported organic synthesis is widely established and this technique is a simple, faster, and e cient technology, it is used to drop off the duration of time to carry diverse organic transformations along with high yield, lowest by-products, and minimum energy utilization with maximum selectivity [12][13][14][15][16]. In prolongation, of our foregoing studies on the development of eco-friendly green methodologies and construction of biological importance molecules [17][18][19][20][21] We report here in a facile and convenient synthetic strategy for the preparation of 4aryltetrazolo [1,5-a] [1,8]naphthyridine derivatives in the presence of simple glacial acetic acid formed high yield and these compounds showed interesting antimicrobial activity.…”