Polymer Adsorption

Pavlukhina, Svetlana; Sukhishvili, Svetlana A.

doi:10.1002/0471440264.pst014.pub2

Cited by 5 publications

(5 citation statements)

References 101 publications

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“…As a result, many bacterial strains and species have become resistant to gentamicin . To overcome such issues, several types of layer-by-layer (LbL) polymer coatings that incorporate antibacterial compounds and continuously release them in a highly localized manner have been explored. − One of the ways has been using pH-responsive drug delivery systems such as pH-responsive coatings. − A significant recent development includes a new family of LbL coatings, which do not elute antibiotics under normal, infection-free conditions, but supply antibiotics locally only when activated by bacteria-induced pH lowering …”

Section: Introductionmentioning

confidence: 99%

Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating

Hizal

Жук

Sukhishvili

et al. 2015

ACS Appl. Mater. Interfaces

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126

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Titanium is often applied in implant surgery, but frequently implicated in infections associated with bacterial adhesion and growth on the implant surface. Here, we show that hierarchical nanostructuring of titanium and the subsequent coating of resulting topographical features with a self-defensive, antibacterial layer-by-layer (LbL) film enables a synergistic action of hierarchical nanotopography and localized, bacteria-triggered antibiotic release to dramatically enhance the antibacterial efficiency of surfaces. Although sole nanostructuring of titanium substrates did not significantly affect adhesion and growth of Staphylococcus aureus, the coating of 3D-nanopillared substrates with an ultrathin tannic acid/gentamicin (TA/G) LbL film resulted in a 10-fold reduction of the number of surface-attached bacteria. This effect is attributed to the enlarged surface area of the nanostructured coating available for localized bacteria-triggered release of antibiotics, as well as to the lower bacterial adhesion forces resulting in subsided activation of bacterial antibiotic-defense mechanisms when bacteria land on nanopillar tips. The result shows that a combination of 3D nanostructuring with a bacteria-triggered antibiotic-releasing coating presents a unique way to dramatically enhance antibacterial efficacy of biomaterial implants.

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Section: Introductionmentioning

confidence: 99%

Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating

Hizal

Жук

Sukhishvili

et al. 2015

ACS Appl. Mater. Interfaces

Self Cite

126

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“…A glycoside hydrolase called dispersin B (DspB), which cleaves poly-N-acetylglucosamine polysaccharides, is another example of an enzyme known to disturb biofilm formation by specifically attacking an extracellular polymeric substances component necessary for biofilm formation [68]. Pavlukhina et al showed that a DspB loaded coating was able to reduce Staphylococcus epidermidis surface coverage by 98% [69]. PMAA surface hydrogels on silicon wafers were prepared by depositing bilayers of PMAA/poly(allylamine hydrochloride) (PAH) which were cross-linked using glutaraldehyde.…”

Section: Antibacterial Enzymesmentioning

confidence: 99%

Current Developments in Antimicrobial Surface Coatings for Biomedical Applications

Swartjes

Sharma²,

Kooten

et al. 2015

CMC

132

104

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Bacterial adhesion and subsequent biofilm formation on material surfaces represent a serious problem in society from both an economical and health perspective. Surface coating approaches to prevent bacterial adhesion and biofilm formation are of increased importance due to the increasing prevalence of antibiotic resistant bacterial strains. Effective antimicrobial surface coatings can be based on an anti-adhesive principle that prevents bacteria to adhere, or on bactericidal strategies, killing organisms either before or after contact is made with the surface. Many strategies, however, implement a multifunctional approach that incorporates both of these mechanisms. For anti-adhesive strategies, the use of polymer chains, or hydrogels is preferred, although recently a new class of super-hydrophobic surfaces has been described which demonstrate improved anti-adhesive activity. In addition, bacterial killing can be achieved using antimicrobial peptides, antibiotics, chitosan or enzymes directly bound, tethered through spacer-molecules or encased in biodegradable matrices, nanoparticles and quaternary ammonium compounds. Notwithstanding the ubiquitous nature of the problem of microbial colonization of material surfaces, this review focuses on the recent developments in antimicrobial surface coatings with respect to biomaterial implants and devices. In this biomedical arena, to rank the different coating strategies in order of increasing efficacy is impossible, since this depends on the clinical application aimed for and whether expectations are short- or long term. Considering that the era of antibiotics to control infectious biofilms will eventually come to an end, the future for biofilm control on biomaterial implants and devices is likely with surface-associated modifications that are non-antibiotic related.

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“…Polymers pose a structure-behavior entropic dependency as well as a multiplicity of contacts with surfaces, which causes an amplification of molecular binding. A consequence of such strong binding is that once adsorbed, a polymer chain cannot easily desorb from the surface due to the prohibitively high energetic barrier for desorption, which requires simultaneous detachment of all monomeric units . This atomistic modeling study seeks to provide insights into these phenomena when water is introduced into the system.…”

Section: Introductionmentioning

confidence: 99%

“…Last, because of the commonly nonreactive binding nature (adhesive binding) of many polymer species used, polymers may be less restricted by the availability of soil minerals as raw reactants dictated by the geochemistry of the environment. While the aforementioned resistance to erodibility of the polymer phases would not compromise the polymer-soil composite due to the strong adsorption that is often achieved with the mineral substrate, 18 the durability of the composite "as a whole" could be transiently compromised by the infiltration of water wetting the interparticle interstices and composite interfaces. This is the major potential disadvantage of polymer-soil composites.…”

Section: ■ Introductionmentioning

confidence: 99%

“…While the aforementioned resistance to erodibility of the polymer phases would not compromise the polymer-soil composite due to the strong adsorption that is often achieved with the mineral substrate, 18 the durability of the composite “as a whole” could be transiently compromised by the infiltration of water wetting the interparticle interstices and composite interfaces. This is the major potential disadvantage of polymer-soil composites.…”

Section: Introductionmentioning

confidence: 99%

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Dynamics of Water Intrusion in Polyelectrolyte-Bound Kaolinite: An Insight into Durability Mechanisms via Atomistic Modeling

Grajales,

Little,

Rushing

2024

ACS Omega

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This research addresses interaction mechanisms of water-soluble polymers used as soil mineral stabilizers via atomistic classical molecular dynamics (MD). Specifically, this study addresses polyelectrolyte interactions with kaolinite, a ubiquitous clay mineral, in soils. The two water-soluble polymeric species evaluated are PSS: poly(4-sodium styrenesulfonate) and PDADMAC: poly(diallyldimethylammonium chloride). The primary focus is the evaluation of water migration through a polymer-kaolinite composite system, the resulting molecular arrangement and interactions, and the extents of water migration through the polymeric phase-binding kaolinite interfacial planes. Mean square displacement (MSD) analysis was used to quantify the motion of the system species from the MD trajectories by calculation of self-diffusion coefficients and comparison of the curves obtained. The MD results indicate that water infiltrates the polyelectrolyte phase adhering to the mineral interfaces. Nevertheless, the MSD analysis results indicate a 55.8% reduction in water self-diffusion with respect to pure mineral-confined water. This is a compelling indication that polyelectrolytes can hinder water movement. Most importantly, MSD analysis of both polyelectrolyte species shows that the movement of the chains is negligible relative to that of water. These results strongly suggest that the movement of polymer phases is restricted only to local chain mobility and a rather bound state to the mineral surfaces prevails.

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Polymer Adsorption

Cited by 5 publications

References 101 publications

Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating

Impact of 3D Hierarchical Nanostructures on the Antibacterial Efficacy of a Bacteria-Triggered Self-Defensive Antibiotic Coating

Current Developments in Antimicrobial Surface Coatings for Biomedical Applications

Dynamics of Water Intrusion in Polyelectrolyte-Bound Kaolinite: An Insight into Durability Mechanisms via Atomistic Modeling

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