Polymer-based biosensor for estrogenic endocrine-disrupting chemicals in water

Rozi, Normazida; Zaid, Mohd Hazani Mat; Tahrim, Nurfaizah Abu; Ikeda, Masato; Hanifah, Sharina Abu

doi:10.1080/03067319.2020.1746776

Cited by 3 publications

(1 citation statement)

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“…The wave of concern over the potential health hazards associated endocrine disrupting chemicals (EDC) toward humans and wildlife began in early 1990, since the discovery of the feminized effect on male fish in rivers downstream of municipal wastewater treatment plants [1,2]. Since then, substantial research efforts have been made to study the possible adverse effects of EDCs by evaluating every type of EDC substance that may be present in the aquatic system [2]. In this group, 17ß-Estradiol (E2) has been identified as one of the emerging pollutants belonging to natural estrogen, which is also known as the most potent EDC in their class.…”

Section: Introductionmentioning

confidence: 99%

A Sensitive Impedimetric Aptasensor Based on Carbon Nanodots Modified Electrode for Detection of 17ß-Estradiol

et al. 2020

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A simple and sensitive aptasensor based on conductive carbon nanodots (CDs) was fabricated for the detection of 17ß-Estradiol (E2). In the present study, the hydrothermal synthesis of carbon nanodots was successfully electrodeposited on a screen-printed electrode (SPE) as a platform for immobilization of 76-mer aptamer probe. The morphology and structure of the nanomaterial were characterized by UV-visible absorption spectra, Fluorescence spectra, Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR). Moreover, cyclic voltammetry and electrochemical impedance spectroscopy were used to investigate the electrochemical performance of the prepared electrodes. Subsequently, impedimetric (EIS) measurements were employed to investigate the relative impedances changes before and after E2 binding, which results in a linear relationship of E2 concentration in the range of 1.0 × 10−7 to 1.0 × 10 −12 M, with a detection limit of 0.5 × 10−12 M. Moreover, the developed biosensor showed high selectivity toward E2 and exhibited excellent discrimination against progesterone (PRG), estriol (E3) and bisphenol A (BPA), respectively. Moreover, the average recovery rate of spiked river water samples with E2 ranged from 98.2% to 103.8%, with relative standard deviations between 1.1% and 3.8%, revealing the potential application of the present biosensor for E2 detection in water samples.

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Section: Introductionmentioning

confidence: 99%