Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems

“…326 A dendritic polyglycerol (dPG) nanogel containing acid-labile benzacetal bonds was prepared. Protein release without loss of activity was achieved at the low pH milieu of acidic cell compartments.…”

“…Protein release without loss of activity was achieved at the low pH milieu of acidic cell compartments. 326,327 Several pH-sensitive DDSs have been developed for targeted delivery of live bacteria ( e.g. Lactobacillus casei ) to the small intestine by protecting from the acidic environment of the stomach ( i.e.…”

Hierarchical mesoporous silica nanoparticles for tailorable drug release

“…Therefore, improving the drug release controllability of MSNs carriers is the key factor to extend their potential usage to the specific needs for various pathological models. To this end, quite a few stimuli-responsive polymers or bio-macromolecules have been applied to modify the simplex MSNs to further endow them with controllable cargo release profiles (Aznar et al, 2013;Chen et al, 2016;Choi et al, 2014;Kim et al, 2014;Niu et al, 2014;Saint-Cricq et al, 2015). On the other hand, it is well known that the functional properties of MSNs usually depend on their structure features, such as different features of pore including size, shape, hydrophilicity/hydrophobicity, and surface charge, some of which have shown controllable drug release capability (Doane and Burda, 2013;Gao et al, 2011;Li et al, 2011;Natarajan and Selvaraj, 2014;Niu et al, 2014;Slowing et al, 2008;Wang et al, 2013;Zhu et al, 2010).…”

The effect of titanium in Li3V2(PO4)3/graphene composites as cathode material for high capacity Li-ion batteries

“…31 The LVP/Ag-graphene composites exhibited reasonable discharge capacity at 0.1 C and capacity retention (78%) at 0.5 C in the potential range of 3.0-4.8 V. Even though the LVP/graphene composite was reported as cathode materials for the LIBs, 21, 28-30 it required multi-steps for sample preparation and was not suitable for large scale.…”

“…Titanium-added Li 3 V 2-x Ti x (PO 4 ) 3 /graphene (Ti-added LVP/graphene, x=0, 0.01, 0.03, and 0.05) composite was synthesized through a sol-gel route by using titanium dioxide (TiO 2 ) and graphene in order to improve the elctrochemical performance. 31 The LVP/Ag-graphene composites exhibited reasonable discharge capacity at 0.1 C and capacity retention (78%) at 0.5 C in the potential range of 3.0-4.8 V.Moreover, the exceptional discharge capacity of 134 mAh g -1 5 solution poured into the graphene solution and stirred by using a magnetic force stirrer for 24 h. The mixture was heated at 80 °C and the resulting slurry was dried at 100 °C, followed by sintered at 350 °C for 4 h and then 800 °C for 8 h under argon atmosphere in a tube furnace.The ramping rate was 5 °C min -1 . …”