Polymer coatings on drug-eluting stents: Samson’s hair and Achilles’ heel?

Basalus, Mounir W.Z.; Joner, Michael; Birgelen, Clemens von; Byrne, Robert A.

doi:10.4244/eijv9i3a51

Cited by 20 publications

(8 citation statements)

References 17 publications

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“…Thrombotic occlusion of a stent in the most proximal coronary segment may result in a particularly large myocardial necrosis with a high clinical risk . Besides a delayed endothelial coverage of DES struts, both vessel wall inflammation and premature occurrence of neoatherosclerosis have been identified as triggers of stent‐thrombosis in durable‐polymer based DES . The two latter factors may be greatly avoided by the use of DES with biodegradable coatings , of which—after degradation of the coating material—only a bare metal stent remains in the coronary artery .…”

Section: Discussionmentioning

confidence: 99%

Clinical outcome of patients with implantation of second‐generation drug‐eluting stents in the right coronary ostium: Insights from 2‐year follow‐up of the TWENTE trial

Lam

Sen

Tandjung

et al. 2014

Cathet Cardio Intervent

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Section: Discussionmentioning

confidence: 99%

Clinical outcome of patients with implantation of second‐generation drug‐eluting stents in the right coronary ostium: Insights from 2‐year follow‐up of the TWENTE trial

Lam

Sen

Tandjung

et al. 2014

Cathet Cardio Intervent

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“…Thrombotic occlusion of a stent in the most proximal coronary segment may result in a particularly large myocardial necrosis with a high clinical risk [25]. Besides a delayed endothelial coverage of DES struts, both vessel wall inflammation and premature occurrence of neoatherosclerosis have been identified as triggers of stent-thrombosis in durable-polymer based DES [26][27][28][29][30]. The two latter factors may be greatly avoided by the use of DES with biodegradable coatings [31,32], of which-after degradation of the coating material-only a bare metal stent remains in the coronary artery [29,33].…”

Section: Discussionmentioning

confidence: 99%

TCT-241 Two-Year Clinical Outcome of Patients With Implantation of Second-Generation Drug-Eluting Stents in the Right Coronary Ostium in the TWENTE Trial

Lam¹,

Sen²,

Houwelingen³

et al. 2014

Journal of the American College of Cardiology

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Objectives: The aim of the present study was to assess the impact on clinical outcome of right coronary artery (RCA) ostial coverage with second-generation drug-eluting stents (DES). Background: Treatment of the aorta-ostial (AO) region of the RCA with bare metal stents and first-generation DES has been associated with a higher risk of target-lesion revascularization (TLR). Methods: Of the 1,391 patients of the prospective TWENTE trial, we identified 321 (23%) with single-vessel RCA treatment, who were categorized into stenting with AO stent coverage (AOC) versus stenting without AOC. The AO region was defined as 3 mm from the aortic orifice. Results: The 67 (20.9%) patients with AOC showed more severe lesion calcifications than the 254 patients without AOC (31.3% vs. 12.6%; P < 0.01). In the AOC group, there was a higher prevalence of hypercholesterolemia and family history of coronary disease (75.4% vs. 61.6%, and 68.7% vs. 53.5%, respectively; P 5 0.03). During 2-year follow-up, patients in the AOC group had a higher incidence of TLR (7.5% vs. 1.6%; P 5 0.02). Following adjustment for confounders, AOC independently predicted TLR with an adjusted hazard ratio of 4.1 (95% CI: 1.17-14.39; P 5 0.03). Conclusion: AO treatment of the RCA with secondgeneration DES is feasible, but our data suggest that stent coverage of the right AO segment remains a predictor of TLR. V C 2014 Wiley Periodicals, Inc.

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“…Up to date, the current commercially available DESs still suffer from weak adhesion between the polymer coating and stent surface. This weakness resulted in polymer detachment and delamination during and after stent deployments could lead to the stent action failure [9][10][11][12][13][14][15][16] and, therefore might increase the likelihood of stent thrombosis and/or restenosis [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

Bedair

et al. 2015

Journal of Colloid and Interface Science

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Polymer coatings on drug-eluting stents: Samson’s hair and Achilles’ heel?

Cited by 20 publications

References 17 publications

Clinical outcome of patients with implantation of second‐generation drug‐eluting stents in the right coronary ostium: Insights from 2‐year follow‐up of the TWENTE trial

Clinical outcome of patients with implantation of second‐generation drug‐eluting stents in the right coronary ostium: Insights from 2‐year follow‐up of the TWENTE trial

TCT-241 Two-Year Clinical Outcome of Patients With Implantation of Second-Generation Drug-Eluting Stents in the Right Coronary Ostium in the TWENTE Trial

Effects of interfacial layer wettability and thickness on the coating morphology and sirolimus release for drug-eluting stent

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