Polymeric Fe₃O₄ Conjugates with Bioactive Plant Molecules: Platforms for Antimicrobial Therapy

Abstract

The emerging nano biosystems are competent in diagnosis, drug delivery, and monitoring of therapeutic response. Both imaging and therapeutic functions can be achieved by using nanoplatforms. These nanoplatforms promise to revolutionize the medical management of many personalized illnesses. The well-developed surface chemistry of iron oxide (Fe3O4) makes it easy to charge them with pharmaceutics, promoting them as nanoplatforms for building up nanoparticle-based drug delivery systems. The strategy to design multifunctional Fe3O4 conjugates with bioactive molecules of plant origin to show enhanced activity is reported here. The conjugation reveals the magnetic Fe3O4 core nanoparticle surface readily link to hydroxyl sites of the Dextrin molecule, which further conjugate to conjugated with Curcumin and D-Limonene, which are powerful anti-cancer, anti-inflammatory, and antioxidant agents. The structural, morphological, optical, and magnetic properties were analyzed by X-ray diffraction, FT-Infrared, HR-Tunneling Electron Microscopy, and Vibrating Sample Magnetometer techniques. The potential drug loading was measured as Drug Entrapment Efficiency using UV-Vis spectroscopy. The antibacterial property was tested on the bacterium S. aureus and E. coli. Fe3O4-Dextrin nanoconjugates proved to be efficient for loading and stabilizing Curcumin and Limonene. Thus, multifunctional Fe3O4 conjugates are explored as exciting nano-drug carriers for targeted drug delivery.

Polymer-Based Nanocomposite Coating Methods: A Review

“…According to the research, structural modification of nanofillers through encapsulating, enveloping, decorating, and other ways is a promising strategy for improving the filler-matrix interactions. The PNCs have significantly enhanced the identification, qualification of disease biomarkers, improving the clinical trials [233].…”

Glucose Functionalized Magnetic Iron Oxide Nanoparticles for Protein Detection and Separation

“…Among the biomolecules, carbohydrates are essential and emerging as carbohydrate-functionalized nanoparticles have been used in different fields of biological science [19][20][21]. In earlier studies, various scientific communities conjugated carbohydrate molecules with nanoparticles using different conjugation chemistry, for example, adsorption of thiolated carbohydrates with nanoparticles via affinity-based interaction [22][23][24][25][26] or linking of carbohydrates via EDC/ DSC/DCC-based conjugation chemistry with nanoparticles [27][28][29], click chemistry [30,31], reductive amination based conjugation chemistry [32][33][34][35] and other methods [36][37][38].…”