2014
DOI: 10.1002/adhm.201400023
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Polymeric‐Gold Nanohybrids for Combined Imaging and Cancer Therapy

Abstract: Here, the use of folic acid (FA)-functionalized, doxorubicin (DOXO)/superparamagnetic iron oxide nanoparticles (SPION)-loaded poly(lactic-co-glycolic acid) (PLGA)-Au porous shell nanoparticles (NPs) as potential nanoplatforms is reported for targeted multimodal chemo- and photothermal therapy combined with optical and magnetic resonance imaging in cancer. These polymeric-gold nanohybrids (PGNH) are produced by a seeded-growth method using chitosan as an electrostatic "glue" to attach Au seeds to DOXO/SPION-PLG… Show more

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Cited by 50 publications
(33 citation statements)
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“…may be independent of the nanogel type (PVCL‐ or PDEAEMA‐based nanogel), at least in the range of concentrations studied. In addition, the total amount of encapsulated drug was higher than that observed using other DDSs such as polymeric micelles based on Pluronics or Tetronics, polyoxyethylene‐based block copolymers, polymeric nanoparticles, and other nanogels, being in all the cases a D.L. of <30 wt %.…”
Section: Resultsmentioning
confidence: 63%
“…may be independent of the nanogel type (PVCL‐ or PDEAEMA‐based nanogel), at least in the range of concentrations studied. In addition, the total amount of encapsulated drug was higher than that observed using other DDSs such as polymeric micelles based on Pluronics or Tetronics, polyoxyethylene‐based block copolymers, polymeric nanoparticles, and other nanogels, being in all the cases a D.L. of <30 wt %.…”
Section: Resultsmentioning
confidence: 63%
“…PLGA nanoparticle (zeta potential −25.03 ± 1.10 mV) surface was functionalized with amine groups using glycol chitosan (GCHT) for the attachment of negatively charged gold seeds via electrostatic force 9 . GCHT coating on the particle was confirmed as the zeta potential changed from −25.03 ± 1.10 mV to +36.35 ± 1.55 mV (Fig.…”
Section: Resultsmentioning
confidence: 99%
“…If the commercialization of nanomaterials for healthcare, especially parenteral administration is anticipated, a thorough biocompatibility and systemic toxicity study is critically required 14 . Enlightened by previous literature where multifunctional gold-coated and also drug loaded PLGA nanoshells have been synthesized for compensating the therapeutic effect of photothermal therapy with chemotherapeutic drugs 8 , 9 . It’s has been evidently noticed that complexity in nanomedicine design has clearly complicated their path towards successful clinical application.…”
Section: Introductionmentioning
confidence: 99%
“…One of these strategies includes functionalization of the NP surface with molecules that can bind the drug of interest so that, upon a temperature change, a conformational change enables release of the drug. [ 167 ] A wide variety of polymeric nanocarriers have been used for drug-release control, which can now be combined with light-responsive agents such as plasmonic nanoparticles, for phototriggered treatments. [ 163 ] Molecular payloads that were linked to NPs via weak interactions can be released upon heating, since the energetic barrier for desorption can be readily overcome.…”
Section: Light-controlled Drug Releasementioning
confidence: 99%