Polymeric Hollow Particles for Encapsulation of Chemical Molecules

Park, Jong Myung

doi:10.1002/9781118729175.ch10

Cited by 2 publications

(4 citation statements)

References 115 publications

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“…% Cumulative release of risedronate from aqueous core-PLGA shell microcapsules and PLGA microspheres in PBS (pH 6.8). Data are given as mean±standard deviation (SD); n=3 for each time point in both curves; ns represents no significant difference at p<0.05 using two-way ANOVA with Bonferroni's multiple comparisons test poly(methyl methacrylate), and poly(isobutyl methacrylate) polymers (10,20).…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, very limited studies have addressed this point in the literature (6,7). These studies came mainly in an attempt to overcome drawbacks related to the conventional w 1 /o/w 2 double emulsion method (6)(7)(8)(9)(10). They involved in situ formation of w 1 /o/w 2 double emulsion from a single o/w emulsion via spontaneous self-emulsification by using either an appropriate emulsifier such as sodium dioctyl sulfosuccinate (Aerosol OT or AOT) (6) or a copolymer as poly(D,L-lactide)-b-poly(2-dimethylaminoethyl methacylate)(PLA-b-PDMAEMA) (7).…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Abulateefeh

Alkilany

2015

AAPS PharmSciTech

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Abstract. The preparation of microcapsules consisting of poly(D,L-lactide-co-glycolide) (PLGA) polymer shell and aqueous core is a clear challenge and hence has been rarely addressed in literature. Herein, aqueous core-PLGA shell microcapsules have been prepared by internal phase separation from acetonewater in oil emulsion. The resulting microcapsules exhibited mean particle size of 1.1±0.39 μm (PDI=0.35) with spherical surface morphology and internal poly-nuclear core morphology as indicated by scanning electron microscopy (SEM). The incorporation of water molecules into PLGA microcapsules was confirmed by differential scanning calorimetry (DSC). Aqueous core-PLGA shell microcapsules and the corresponding conventional PLGA microspheres were prepared and loaded with risedronate sodium as a model drug. Interestingly, aqueous core-PLGA shell microcapsules illustrated 2.5-fold increase in drug encapsulation in comparison to the classical PLGA microspheres (i.e., 31.6 vs. 12.7%), while exhibiting sustained release behavior following diffusion-controlled Higuchi model. The reported method could be extrapolated to encapsulate other water soluble drugs and hydrophilic macromolecules into PLGA microcapsules, which should overcome various drawbacks correlated with conventional PLGA microspheres in terms of drug loading and release.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Abulateefeh

Alkilany

2015

AAPS PharmSciTech

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“…Hollow latex (HL) or void-containing particles have unique properties in terms of lightweight, high opacity, and high volume fraction for encapsulation. 1,2 The polymeric HL particles are of technological interest due to their remarkable properties including controllable size, shape, and shell thickness, tunable chemical functionality, robust shell and porosity, as well as facile processability. 3,4 Such particles offer numerous applications especially in coatings, electronics, catalysis, cosmetics, and biomedical fields.…”

Section: Introductionmentioning

confidence: 99%

“…Hollow latex (HL) or void-containing particles have unique properties in terms of lightweight, high opacity, and high volume fraction for encapsulation. , The polymeric HL particles are of technological interest due to their remarkable properties including controllable size, shape, and shell thickness, tunable chemical functionality, robust shell and porosity, as well as facile processability. , Such particles offer numerous applications especially in coatings, electronics, catalysis, cosmetics, and biomedical fields. The most common procedure used to prepare polymeric HL particles is the template-based strategy. , The sacrificed core or template, which can be hard colloidal particle or soft matter, is coated by the desired shell and, after template removal, HL particle is produced.…”

Section: Introductionmentioning

confidence: 99%

Review on Synthesis of Colloidal Hollow Particles and Their Applications

Wichaita

Polpanich

Tangboriboonrat

2019

Ind. Eng. Chem. Res.

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Hollow latex (HL) particles of polymers or hybrid polymer/inorganic materials have advantages in efficient encapsulation of active ingredients, ability to improve opacity or hiding power, and low density. Due to the flexible design for achieving the desired functionality, polymeric HL particles serve as stimuli-responsive capsules for drug delivery and cosmetics, white pigment for coatings, as well as nanoreactors for the confined reactions. Among numerous studies on the synthesis of HL particles for specific applications, this review article summarizes the recent works on the HL particles prepared from both synthetic and natural polymers. The template-based methods using sacrificial hard or soft template, self-templating, and nonsacrificial techniques are described. Various factors affecting morphologies and properties of HL particles are discussed in detail. Their applications in coatings, cosmetics, biomedicines, electronics, and others are also presented.

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Polymeric Hollow Particles for Encapsulation of Chemical Molecules

Cited by 2 publications

References 115 publications

Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Review on Synthesis of Colloidal Hollow Particles and Their Applications

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