Polymeric membrane based on polyactic acid and babassu oil for wound healing

Fernandes, Diogo M.; Barbosa, Wagner S.; Rangel, Weslley S.P.; Valle, Isabella Mourão M.; Matos, Ana Paula dos Santos; Melgaço, Fabiana Gil; Dias, Marcos L.; Júnior, Eduardo Ricci; Silva, Luiz Cláudio P. da; Abreu, Letícia Coli Louvisse de; Monteiro, Mariana de Souza de Bustamante Sato

doi:10.1016/j.mtcomm.2021.102173

Cited by 22 publications

(16 citation statements)

References 48 publications

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“…K. pneumoniae is associated with a variety of infections, including wounds and disseminated infections. Babassu oil fibers with PLA were produced to aid in the healing process, and in the antimicrobial assay, only inhibition was observed for Gram-negative bacteria [64]. Mauritia flexuosa oil and CG showed no antibacterial action against this strain at the concentrations tested.…”

Section: Antibacterial Testsmentioning

confidence: 99%

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

et al. 2022

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Wounds are considered a clinically critical issue, and effective treatment will decrease complications, prevent chronic wound formation, and allow rapid healing. The development of products based on naturally occurring materials is an efficient approach to wound healing. Natural polysaccharides can mimic the extracellular matrix and promote cell growth, thus making them attractive for wound healing. In this context, the aim of this work was to produce a gel based on chicha gum, chitosan, and Mauritia flexuosa oil (CGCHO) for wound treatment. TG and DTG analyzed the thermal behavior of the materials, and SEM investigated the surface roughness. The percentages of total phenolic compounds, flavonoids, and antioxidants were determined, presenting a value of 81.811 ± 7.257 µmol gallic acid/g Mauritia flexuosa oil, 57.915 ± 0.305 µmol quercetin/g Mauritia flexuosa oil, and 0.379 mg/mL, respectively. The anti-inflammatory was determined, presenting a value of 10.35 ± 1.46% chicha gum, 16.86 ± 1.00% Mauritia flexuosa oil, 10.17 ± 1.05% CGCHO, and 15.53 ± 0.65% chitosan, respectively. The materials were tested against Gram-negative (Klebsiella pneumoniae) and Gram-positive (Staphylococcus aureus) bacteria and a fungus (Candida albicans). The CGCHO formulation showed better antimicrobial activity against Gram-positive bacteria. In addition, an in vivo wound healing study was also performed. After 21 days of treatment, the epidermal re-epithelialization process was observed. CGCHO showed good thermal stability and roughness that can help in cell growth and promote the tissue healing process. In addition to the good results observed for the antimicrobial, antioxidant, anti-inflammatory activities and providing wound healing, they provided the necessary support for the healing process, thus representing a new approach to the wound healing process.

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Section: Antibacterial Testsmentioning

confidence: 99%

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

et al. 2022

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“…In an attempt to reduce the effects of adverse antibiotics, modern wound dressings loaded with natural antimicrobial agents such as proanthocyanidins (PCAN) extracted from Pelargonium sidoides [ 161 ], Annona leaf extracts [ 164 ], babassu oil [ 19 ], Hypericum perforatum oil (HPO) [ 21 ], melanin [ 18 ], and arginine and chitosan [ 174 ] were developed. Immunomodulatory properties toward skin keratinocytes in vitro were related in the case of olive leaf extract (OLE) incorporation in poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV) and PHB/poly(hydroxyoctanoate-co-hydroxydecanoate) (PHB/PHOHD) nanofibers, due to the antioxidant activity of oleuropein [ 175 ].…”

Section: Wound Dressingsmentioning

confidence: 99%

“…Wound-dressing materials should have important requirements related to their biocompatibility [ 15 ], wound healing [ 16 ], wound adhesion [ 17 , 18 ], maintenance of wound moisture [ 19 , 20 ], inhibition of the growth of bacteria [ 15 , 21 , 22 ], removal of excess exudates, and reductions in the dressing frequency [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Special Features of Polyester-Based Materials for Medical Applications

Darie-Niță¹,

Râpă

Frąckowiak

2022

Polymers

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This article presents current possibilities of using polyester-based materials in hard and soft tissue engineering, wound dressings, surgical implants, vascular reconstructive surgery, ophthalmology, and other medical applications. The review summarizes the recent literature on the key features of processing methods and potential suitable combinations of polyester-based materials with improved physicochemical and biological properties that meet the specific requirements for selected medical fields. The polyester materials used in multiresistant infection prevention, including during the COVID-19 pandemic, as well as aspects covering environmental concerns, current risks and limitations, and potential future directions are also addressed. Depending on the different features of polyester types, as well as their specific medical applications, it can be generally estimated that 25–50% polyesters are used in the medical field, while an increase of at least 20% has been achieved since the COVID-19 pandemic started. The remaining percentage is provided by other types of natural or synthetic polymers; i.e., 25% polyolefins in personal protection equipment (PPE).

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“…Researchers have been worked about the development antibacterial PLA-based electrospun materials using chitosan and silver [43], thymol [44], propolis [45], silver and vitamin E [46], copaiba (Copaifera sp.) oil [47], tetracycline hydrochloride and chitosan [48], cinnamon essential oil [49], thymoquinone [50], tea tree and manuka oil [51], carvacrol [52], clary sage and black pepper [53], terpinen-4-ol [54], epidermal growth factor [55], quercetin [56], Nigella sativa herbal extract [57], Eucalyptus essential oil [58], silver diclofenac complex [59], chitosan, black pepper essential oil and limonene [60], selenium and clarithromycin [61], cefazolin [62], silver nanoparticles [63], zinc oxide [64], thyme essential oil [65], zenian (Carum copticum) essential oil [66], birch bark triterpene extract [67], Capparis spinosa L. extracts [68], Plumbago europaea plant extract [69], curcumin [70], babassu oil [71], and cypress (Cupressus sempervirens L.) essential oil [72].…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications

et al. 2021

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The growth of population and increase in diseases that cause an enormous demand for biomedical material consumption is a pointer to the pressing need to develop new sustainable biomaterials. Electrospun materials derived from green polymers have gained popularity in recent years for biomedical applications such as tissue engineering, wound dressings, and drug delivery. Among the various bioengineering materials used in the synthesis of a biodegradable polymer, poly(lactic acid) (PLA) has received the most attention from researchers. Hypericum perforatum oil (HPO) has antimicrobial activity against a variety of bacteria. This study aimed to investigate the development of an antibacterial sustainable material based on PLA by incorporating HPO via a simple, low-cost electrospinning method. Chemical, morphological, thermal, thickness and, air permeability properties, and in vitro antibacterial activity of the electrospun nonwoven fabric were investigated. Scanning electron microscopy (SEM) was used to examine the morphology of the electrospun nonwoven fabric, which had bead-free morphology ultrafine fibers. Antibacterial tests revealed that the Hypericum perforatum oil-loaded poly(lactic acid) nonwoven fabrics obtained had high antibacterial efficiency against Escherichia coli and Staphylococcus aureus, indicating a strong potential for use in biomedical applications.

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Polymeric membrane based on polyactic acid and babassu oil for wound healing

Cited by 22 publications

References 48 publications

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

Potential Wound Healing Effect of Gel Based on Chicha Gum, Chitosan, and Mauritia flexuosa Oil

Special Features of Polyester-Based Materials for Medical Applications

An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications

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