Polymeric micelles: Basic research to clinical practice

Deshmukh, Anand S.; Chauhan, Pratik; Noolvi, Malleshappa N.; Chaturvedi, Kiran; Ganguly, Kuntal; Shukla, Shyam S.; Nadagouda, Mallikarjuna N.; Aminabhavi, Tejraj M.

doi:10.1016/j.ijpharm.2017.09.005

Cited by 206 publications

(109 citation statements)

References 192 publications

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“…PEG is the hydrophilic portion and polyvinylcaprolactam-polyvinylacetate moieties are arranged in the hydrophobic core. The polymeric micelles have the possibility of incorporating functionality in both core and shell regions: the hydrophobic molecules in the core, less hydrophobic molecules in the core, but near the hydrophilic moiety [18].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

et al. 2019

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Posidonia oceanica (L.) Delile is a marine plant endemic of Mediterranean Sea endowed with interesting bioactivities. The hydroalcholic extract of P. oceanica leaves (POE), rich in polyphenols and carbohydrates, has been shown to inhibit human cancer cell migration. Neuroblastoma is a common childhood extracranial solid tumor with high rate of invasiveness. Novel therapeutics loaded into nanocarriers may be used to target the migratory and metastatic ability of neuroblastoma. Our goal was to improve both the aqueous solubility of POE and its inhibitory effect on cancer cell migration. Methods: Chitosan nanoparticles (NP) and Soluplus polymeric micelles (PM) loaded with POE have been developed. Nanoformulations were chemically and physically defined and characterized. In vitro release studies were also performed. Finally, the inhibitory effect of both nanoformulations was tested on SH-SY5Y cell migration by wound healing assay and compared to that of unformulated POE. Results: Both nanoformulations showed excellent physical and chemical stability during storage, and enhanced the solubility of POE. PM-POE improved the inhibitory effect of POE on cell migration probably due to the high encapsulation efficiency and the prolonged release of the extract. Conclusions: For the first time, a phytocomplex of marine origin, i.e., P. oceanica extract, has enhanced in terms of acqueous solubility and bioactivity once encapsulated inside nanomicelles.

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Section: Introductionmentioning

confidence: 99%

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

et al. 2019

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“…Micelles are studies for drug delivery system mostly composed of diblock, triblock copolymers or graft copolymers with hydrophilic or hydrophobic segments. Polymeric micelles have unique properties, such as low molecular weight, maximum encapsulation of drug, better stability, lower critical micelle concentration (CMC), and improved and higher drug accumulation at the tumour site for targeting [40]. This nanodrug delivery comprising of star-shaped CDDPloaded micelles was fabricated via the ring-opening polymerization method for passive targeting drug delivery system.…”

Section: Micellesmentioning

confidence: 99%

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

Farooq

Aquib

Farooq

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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2019) Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview, Artificial ABSTRACT Cisplatin cis-(diammine)dichloridoplatinum(II) (CDDP) is the first platinum-based complex approved by the food and drug administration (FDA) of the United States (US). Cisplatin is the first line chemotherapeutic agent used alone or combined with radiations or other anti-cancer agents for a broad range of cancers such as lung, head and neck. Aroplatin TM , Lipoplatin TM and SPI-077 are PEGylated liposomebased nano-formulations that are still under clinical trials. They have many limitations, for example, poor aqueous solubility, drug resistance and toxicities, which can be overcome by encapsulating the cisplatin in Nemours nanocarriers. The extensive literature from different electronic databases covers the different nano-delivery systems that are developed for cisplatin. This review critically emphasizes on the recent advancement, development, innovations and updated literature reported for different carrier systems for CDDP. ARTICLE HISTORY Current status of FDA-approved/under clinical trials CDDP nano-formulationsMany liposomal-based nano-formulations are at the stage of clinical trials. One of under clinical trials drugs, Lipoplatin (Regulon, Inc.), is liposome-based platinum formulation under Phase III clinical trials [11]. It contains a combination of cisplatin (9%) and lipids (91%(w/w)), including soy phosphatidylcholine (SPC-3), cholesterol, dipalmitoyl phosphatidyl glycerol (DPPG) and methoxy-PEG-distearoyl phosphatidyl

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“…Recently, stimuli-responsive micelles have gained a widespread interest for their outstanding advantages [3]. More specifically, the micelles formed from amphiphilic copolymers can effectively encapsulate the hydrophobic drug in the hydrophobic inner core, and the hydrophilic outer shell can improve the compatibility of the system [4]. Due to the leaky vasculature in solid tumor tissues, the nanosized micelles can efficiently accumulate within tumor sites via the enhanced permeability and retention (EPR) effect [5].…”

Section: Introductionmentioning

confidence: 99%

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

et al. 2020

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In this study, a redox-sensitive chitosan derivative with modifications by cholesterol, sulfhydryl, and mPEG (mPEG-CS(SH)-CHO) was successfully synthesized and characterized. Due to its amphiphilicity, the conjugate could spontaneously form micelles in an aqueous environment. The optimized paclitaxel (PTX)-loaded mPEG-CS(SH)-CHO micelles, with a mean diameter of 158 nm, zeta potential of +26.9 mV, drug loading of 11.7%, and entrapment efficiency of 88.3%, were successfully prepared. The results of an XRD study demonstrated that PTX was loaded in the core of the micelles in a non-crystalline state. Inspiringly, the PTX-loaded micelles possessed excellent anticancer effect but low toxicity to the body. It can be concluded that the mPEG-CS(SH)-CHO micellar system is a promising drug delivery carrier for the controlled release of PTX.

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Polymeric micelles: Basic research to clinical practice

Cited by 206 publications

References 192 publications

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Comparison of Chitosan Nanoparticles and Soluplus Micelles to Optimize the Bioactivity of Posidonia oceanica Extract on Human Neuroblastoma Cell Migration

Recent progress in nanotechnology-based novel drug delivery systems in designing of cisplatin for cancer therapy: an overview

A Chitosan-Based Micellar System as Nanocarrier For the Delivery of Paclitaxel

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