Polymeric Nanoparticles

Jarai, Bader M; Kolewe, Emily L.; Stillman, Zachary; Raman, Nisha; Fromen, Catherine A.

doi:10.1016/b978-0-12-816662-8.00018-7

Cited by 35 publications

(22 citation statements)

References 255 publications

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“…The pbENPs used in nanomedicine are categorized based on the type of polymer used: natural or synthetic molecules. According to Jarai et al (2020) [6], important natural polymers include polysaccharides, such as chitosan, cellulose, and hyaluronic acid, as well as natural proteins. The synthetic polymers most often used in nanomedicine are: (1) Polyesters ((poly(glycolic acid) (PGA), poly(lactic acid) (PLA), poly(lactic-coglycolic acid) (PLGA), poly(ε-caprolactone) (PCL)); (2) polyanhydrides; (3) polyamines ((Poly(ethylenimine) (PEI)); (4) Temperature-responsive polymers, such as poly(Nisopropylacrylamide) (PNIPAM); and (5) pH-responsive polymers, such as acetals, hydrazones, and diorthoesters.…”

Section: Introductionmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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The field of veterinary medicine needs new solutions to address the current challenges of antibiotic resistance and the need for increased animal production. In response, a multitude of delivery systems have been developed in the last 20 years in the form of engineered nanoparticles (ENPs), a subclass of which are polymeric, biodegradable ENPs, that are biocompatible and biodegradable (pbENPs). These platforms have been developed to deliver cargo, such as antibiotics, vaccines, and hormones, and in general, have been shown to be beneficial in many regards, particularly when comparing the efficacy of the delivered drugs to that of the conventional drug applications. However, the fate of pbENPs developed for veterinary applications is poorly understood. pbENPs undergo biotransformation as they are transferred from one ecosystem to another, and these transformations greatly affect their impact on health and the environment. This review addresses nanoparticle fate and impact on animals, the environment, and humans from a One Health perspective.

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Section: Introductionmentioning

confidence: 99%

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

et al. 2021

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“…Unsurprisingly, the role of material selection is critically important to tuning and directing these responses. Some materials used to fabricate nano-and microparticles have been shown to cause strong inflammatory or toxic effects on macrophages [7], while recent advances in biomaterials have elucidated classes of modular materials with strong biocompatibility [8][9][10][11]. Early generations of particulate therapeutics sought engineering solutions that avoided internalization by phagocytic immune cells to ensure successful cargo delivery [12,13]; however, an emerging alternative is to promote controlled interactions with innate immune cells to regulate immune response [14,15].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Internalization Promotes the Survival of Primary Macrophages

Jarai

Fromen

2021

Preprint

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Macrophages, a class of tissue resident innate immune cells, are responsible for sequestering foreign objects through the process of phagocytosis, making them a promising target for immune-modulation via particulate engineering. Here, we report that nanoparticle (NP) dosing and cellular internalization via phagocytosis significantly enhances survival of ex vivo cultures of primary bone marrow-derived, alveolar, and peritoneal macrophages over particle-free controls. The enhanced survival is attributed to suppression of caspase-dependent apoptosis and is linked to phagocytosis and lysosomal signaling, which was also found to occur in vivo. Uniquely, poly(ethylene glycol)-based NP treatment does not alter macrophage polarization or lead to inflammatory effects. The enhanced survival phenomenon is also applicable to NPs of alternative chemistries, indicating the potential universality of this phenomenon with relevant drug delivery particles. These findings provide a framework for extending the lifespan of primary macrophages ex vivo for drug screening, vaccine studies, and cell therapies and has implications for any in vivo particulate immune-engineering applications.

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“…However, contrary to inorganic NPs, whose reproducibility is maintained with production, organic NPs have a significant batch-to-batch variability, displaying a range of physical and chemical properties that result from the poor control over the synthesis and fabrication processes. Because of that, very little reports have been published on the combination of these NPs with biocomposites [99,101,136].…”

Section: Nanoparticles (Nps)mentioning

confidence: 99%

Biofunctionalization of Natural Fiber-Reinforced Biocomposites for Biomedical Applications

et al. 2020

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In the last ten years, environmental consciousness has increased worldwide, leading to the development of eco-friendly materials to replace synthetic ones. Natural fibers are extracted from renewable resources at low cost. Their combination with synthetic polymers as reinforcement materials has been an important step forward in that direction. The sustainability and excellent physical and biological (e.g., biocompatibility, antimicrobial activity) properties of these biocomposites have extended their application to the biomedical field. This paper offers a detailed overview of the extraction and separation processes applied to natural fibers and their posterior chemical and physical modifications for biocomposite fabrication. Because of the requirements for biomedical device production, specialized biomolecules are currently being incorporated onto these biocomposites. From antibiotics to peptides and plant extracts, to name a few, this review explores their impact on the final biocomposite product, in light of their individual or combined effect, and analyzes the most recurrent strategies for biomolecule immobilization.

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Polymeric Nanoparticles

Cited by 35 publications

References 255 publications

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Fate of Biodegradable Engineered Nanoparticles Used in Veterinary Medicine as Delivery Systems from a One Health Perspective

Nanoparticle Internalization Promotes the Survival of Primary Macrophages

Biofunctionalization of Natural Fiber-Reinforced Biocomposites for Biomedical Applications

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