Polymeric nanotechnologies for the treatment of periodontitis: A chronological review

Uskoković, Vuk; Pejčić, Ana; Koliqi, Rozafa; Andelković, Z

doi:10.1016/j.ijpharm.2022.122065

Cited by 19 publications

(13 citation statements)

References 198 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Periodontitis is a microbially induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone [1,2]. It constitutes the principal cause of teeth loss in adults, affecting 20-50% of the population worldwide [3].…”

Section: Introductionmentioning

confidence: 99%

“…The optimal target of reestablishing tooth functionality is achieved with periodontal regeneration procedures that try to restore the damaged periodontal apparatus to its initial state [2,3]. Periodontal tissue regeneration treatment has shown remarkable results in the reconstruction of periodontal tissue and is based on the utilization of guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier, isolating the fastgrowing epithelium and providing adequate time and space for PDL cells and osteoblasts to proliferate and counter effect attachment loss [1,3,7,8].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, nanofibers have emerged as a new approach in periodontal tissue engineering [2,3], as nanofibrous scaffolds designed to resemble the natural architecture of the extracellular matrix (ECM) have been shown to enhance cell proliferation and differentiation and are nowadays developed as carriers and support structures for cells, growth factors, bioactive, and antiseptic/antimicrobial substances [12][13][14]. Electrospinning is a versatile technique and the most successful method used for the preparation of ultrafine fibers with sizes ranging from the micrometer to the nanometer scale, and it exhibits great potential for fabricating membranes for periodontal regeneration [5,15,16].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration

Kikionis,

Iliou,

Karra

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

Periodontitis is a microbially-induced inflammation of the periodontium that is characterized by the destruction of the periodontal ligament (PDL) and alveolar bone and constitutes the principal cause of teeth loss in adults. Periodontal tissue regeneration can be achieved through guided tissue/bone regeneration (GTR/GBR) membranes that act as a physical barrier preventing epithelial infiltration and providing adequate time and space for PDL cells and osteoblasts to proliferate into the affected area. Electrospun nanofibrous scaffolds, simulating the natural architecture of the extracellular matrix (ECM), have attracted increasing attention in periodontal tissue engineering. Carrageenans are ideal candidates for the development of novel nanofibrous GTR/GBR membranes, since previous studies have highlighted the potential of carrageenans for bone regeneration by promoting the attachment and proliferation of osteoblasts. Herein, we report the development of bi- and tri-layer nanofibrous GTR/GBR membranes based on carrageenans and other biocompatible polymers for the regeneration of periodontal tissue. The fabricated membranes were morphologically characterized, and their thermal and mechanical properties were determined. Their periodontal tissue regeneration potential was investigated through the evaluation of cell attachment, biocompatibility, and osteogenic differentiation of human PDL cells seeded on the prepared membranes.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration

Kikionis,

Iliou,

Karra

et al. 2023

Marine Drugs

View full text Add to dashboard Cite

show abstract

“…Recently, multifunctional nanoparticles have gained increased attention due to their numerous alterations and characteristics that can boost functionality, dispersibility, and stability. 30–35 However, many previously reported nanoparticles have poor permeability in periodontal pockets, 36–41 being attributed to the complex structure of the constricted and deep periodontal pocket.…”

Section: Introductionmentioning

confidence: 99%

Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model

Tong¹,

Wang²,

Chen³

et al. 2023

IJN

View full text Add to dashboard Cite

Introduction The critical challenge for periodontitis therapy is thoroughly eliminating the dental plaque biofilm, particularly penetrating the deep periodontal tissue. Regular therapeutic strategies are insufficient to penetrate the plaque without disturbing the commensal microflora of the oral cavity. Here, we constructed a Fe 3 O 4 magnetic nanoparticle loading minocycline (FPM NPs) to penetrate the biofilm physically and effectively eliminate periodontal biofilm. Methods In order to penetrate and remove the biofilm effectively, Fe 3 O 4 magnetic nanoparticles were modified with minocycline using a co-precipitation method. The particle size and dispersion of the nanoparticles were characterized by transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. The antibacterial effects were examined to verify the magnetic targeting of FPM NPs. Confocal laser scanning microscopy was employed to check the effect of FPM + MF and develop the best FPM NPs treatment strategy. Additionally, the therapeutic effect of FPM NPs was investigated in periodontitis rat models. The expression of IL-1β, IL-6, and TNF-α in periodontal tissues was measured by qRT-PCR and Western blot. Results The multifunctional nanoparticles exhibited intense anti-biofilm activity and good biocompatibility. The magnetic forces could pull FMP NPs against the biofilm mass and kill bacteria deep in the biofilms both in vivo and in vitro. The integrity of the bacterial biofilm is disrupted under the motivation of the magnetic field, allowing for improved drug penetration and antibacterial performance. The periodontal inflammation recovered well after FPM NPs treatment in rat models. Furthermore, FPM NPs could be monitored in real-time and have magnetic targeting potentials. Conclusion FPM NPs exhibit good chemical stability and biocompatibility. The novel nanoparticle presents a new approach for treating periodontitis and provides experimental support for using magnetic-targeted nanoparticles in clinic applications.

show abstract

“…Nowadays, the development of such synthetic polymers with well-defined sequences and their complementary use along natural or biological polymers is impacting extensively various areas of chemistry, biochemistry, molecular biology, nanotechnology, electronics, medicine, life sciences, biomaterials etc. [ 1 , 2 , 3 , 4 , 5 , 6 ]. Traditionally, synthetic polymers used in healthcare applications were often borrowed from other industries without significant modifications for medical use.…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Amphiphilic Graft Polyphosphazene Micelles for Docetaxel Delivery

Serbezeanu¹,

Vlad‐Bubulac²,

Macsim³

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

The structural versatility of polydichlorophosphazene derived from the inestimable possibilities to functionalize the two halogens, attached to each phosphazene main chain unit, attracted increasing attention in the last decade. This uncountable chemical derivatization is doubled by the amphiphilic roleplay demonstrated by polyphosphazenes containing twofold side-chained hydrophilic and hydrophobic moieties. Thus, it is able to encapsulate specific bioactive molecules for various targeted nanomedicine applications. A new amphiphilic graft, polyphosphazenes (PPP/PEG–NH/Hys/MAB), was synthesized via the thermal ring-opening polymerization of hexachlorocyclotriphosphazene, followed by a subsequent two-step substitution reaction of chlorine atoms with hydrophilic methoxypolyethylene glycol amine/histamine dihydrochloride adduct (PEG–NH2)/(Hys) and hydrophobic methyl-p-aminobenzoate (MAB), respectively. Fourier transform infrared spectroscopy (FTIR) and 1H and 31P-nuclear magnetic resonance spectroscopy (NMR) have been used to validate the expected architectural assembly of the copolymer. Docetaxel loaded micelles based on synthesized PPP/PEG–NH/Hys/MAB were designed by dialysis method. The micelles size was evaluated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The drug release profiles from the PPP/PEG–NH/Hys/MAB micelles were established. In vitro cytotoxicity tests of PPP/PEG–NH/Hys/MAB micelles loaded with Docetaxel revealed that designed polymeric micelles exhibited an increased cytotoxic effect on MCF-7 cells.

show abstract

Polymeric nanotechnologies for the treatment of periodontitis: A chronological review

Cited by 19 publications

References 198 publications

Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration

Development of Bi- and Tri-Layer Nanofibrous Membranes Based on the Sulfated Polysaccharide Carrageenan for Periodontal Tissue Regeneration

Combined Ferromagnetic Nanoparticles for Effective Periodontal Biofilm Eradication in Rat Model

Design and Synthesis of Amphiphilic Graft Polyphosphazene Micelles for Docetaxel Delivery

Contact Info

Product

Resources

About