Polymers, scaffolds and bioactive molecules with therapeutic properties in osteochondral pathologies: what’s new?

López‐Ruiz, Elena; Jiménez, Gema; García, María Ángel; Antich, Cristina; Boulaiz, Houría; Marchal, Juan Antonio; Perán, Macarena

doi:10.1080/13543776.2016.1203903

Cited by 14 publications

(8 citation statements)

References 74 publications

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“…Collagen fibers within the lower zone, align vertical to the bone, and the main cell category gathers itself in columns [36]. Approaching the calcified zone, more chondrocytes have a tendency to express several forms of collagen, and the production of ECM is increased [37]. Chondrocyte metabolism is affected by growth factors, electrical fields, matrix composition, mechanical loads, and hydrostatic pressures [38].…”

Section: Articular Cartilagementioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

109

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The repair and regeneration of articular cartilage represent important challenges for orthopedic investigators and surgeons worldwide due to its avascular, aneural structure, cellular arrangement, and dense extracellular structure. Although abundant efforts have been paid to provide tissue-engineered grafts, the use of therapeutically cell-based options for repairing cartilage remains unsolved in the clinic. Merging a clinical perspective with recent progress in nanotechnology can be helpful for developing efficient cartilage replacements. Nanomaterials, < 100 nm structural elements, can control different properties of materials by collecting them at nanometric sizes. The integration of nanomaterials holds promise in developing scaffolds that better simulate the extracellular matrix (ECM) environment of cartilage to enhance the interaction of scaffold with the cells and improve the functionality of the engineered-tissue construct. This technology not only can be used for the healing of focal defects but can also be used for extensive osteoarthritic degenerative alterations in the joint. In this review paper, we will emphasize the recent investigations of articular cartilage repair/regeneration via biomaterials. Also, the application of novel technologies and materials is discussed.

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Section: Articular Cartilagementioning

confidence: 99%

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Eftekhari

Dizaj

Sharifi

et al. 2020

IJMS

109

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“…Morphology of scaffold surface is an important factor. While porosity of scaffold material mimics the microstructure of cancellous bone or cartilage, the surface properties of biomaterials play a major role in cellular interactions, such as cell adhesion, infiltration and proliferation [23,24]. In present study, morphological analyses demonstrated that osteoblasts and chondrocytes adhere on the surface and moved within the pores of the bilayer scaffolds of loofah+PLLA+cellulose and loofah+PLLA+chitin.…”

Section: Discussionmentioning

confidence: 75%

Two Layered Scaffolds (Loofah/PLLA/Cellulose/Chitin) for Repair of Osteochondral Defect

Çeçen¹,

Kozacı²,

Yüksel³

et al. 2017

J Tissue Sci Eng

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Research of tissue engineering and regenerative medicine continues to develop advanced materials that can better mimic the significant architecture and functional properties of native tissues. Treatment of osteochondral injuries by using scaffolds contains the problem of fixation and integration of the engineered tissue to the surrounding one. Therefore, tissue engineered osteochondral graft design must be directed not only to the injured cartilage but also to the subchondral bone for a sufficient osteochondral repair and integration of the neo-cartilage into the osseous surrounding. In this study, we produced a bilayer scaffold and investigated the ability of co-cultures of chondrocytes and osteoblasts to repair articular cartilage in osteochondral defects. For this purpose, fibrin glued loofah+PLLA+cellulose scaffold with MG-63 cells and loofah+PLLA+chitin scaffold with SW-1353 cells were used to promote bone and cartilage regeneration, respectively. Viability tests and morphology images indicated that this bilayer scaffold had good affinity for osteoblast and chondrocytes cells, encouraging their growth, proliferation and attachment. Histological and immune-histochemical staining analyses confirmed that loofah bilayer scaffolds provided a good support for the cells. Based on the preliminary results in vitro, we suggest that the integrated bilayer scaffold consisting of loofah+PLLA+cellulose and loofah+PLLA+chitin, has potential use to repair osteochondral defects, either upon cellular implantation and/or in acellular form.Citation: Cecen B, Kozaci LD, YuksEL M, Kara A, Ersoy N, et al. (2017) Two Layered Scaffolds (Loofah/PLLA/Cellulose/Chitin) for Repair of Osteochondral Defect. J Tissue Sci Eng 8: 210.

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“…Bioactive factors are crucial in treating osteochondral defects. Growth factors are among the most frequently used chondrogenic differentiation factors in cartilage regeneration, and their effectiveness in treating osteochondral defects has been extensively verified [ 75 ]. Furthermore, unique chondrogenic−inducing factors, such as small molecule drugs and peptides, have been shown to have a higher chondrogenic capability [ [76] , [77] , [78] ].…”

Section: Articular Cartilage Regeneration Under Abnormal Conditionsmentioning

confidence: 99%

Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

Wang

et al. 2022

Bioactive Materials

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The development of interdisciplinary biomedical engineering brings significant breakthroughs to the field of cartilage regeneration. However, cartilage defects are considerably more complicated in clinical conditions, especially when injuries occur at specific sites ( e.g. , osteochondral tissue, growth plate, and weight-bearing area) or under inflammatory microenvironments ( e.g. , osteoarthritis and rheumatoid arthritis). Therapeutic implantations, including advanced scaffolds, developed growth factors, and various cells alone or in combination currently used to treat cartilage lesions, address cartilage regeneration under abnormal conditions. This review summarizes the strategies for cartilage regeneration at particular sites and pathological microenvironment regulation and discusses the challenges and opportunities for clinical transformation.

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Polymers, scaffolds and bioactive molecules with therapeutic properties in osteochondral pathologies: what’s new?

Cited by 14 publications

References 74 publications

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

The Use of Nanomaterials in Tissue Engineering for Cartilage Regeneration; Current Approaches and Future Perspectives

Two Layered Scaffolds (Loofah/PLLA/Cellulose/Chitin) for Repair of Osteochondral Defect

Instructive cartilage regeneration modalities with advanced therapeutic implantations under abnormal conditions

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