Polymethylmethacrylate (PMMA) sub-microparticles produced by Supercritical Assisted Injection in a Liquid Antisolvent

α-Tocopherol nanosuspensions produced using a supercritical assisted process

“…3, the key role of injection pressure is evident: a large reduction of particles dimension was obtained. A possible explanation is that at higher injection pressures the mixing between solvent and antisolvent is improved thanks to the increase of jet turbulence, as also discussed in a previous work (Campardelli et al, 2014).…”

“…Moreover SAILA technique is performed as a continuous process; it allows the direct production of particles in stabilized water suspensions in a single step. In previous works, SAILA process has been proposed and successfully demonstrated for polymeric particles production such as polycaprolactone (PCL) (Campardelli et al, 2012a) and polymethylmethacrylate (Campardelli et al, 2014). Non coalescing nanoparticles were produced and the effect of different process conditions on particles size distribution was studied.…”

Folic acid–PVP nanostructured composite microparticles by supercritical antisolvent precipitation

“…They have been successfully applied in several fields such as the micronization of several kind of materials [13][14][15][16][17][18][19][20], extraction of natural matter [21], impregnation of metals or drugs in aerogels [22,23], membranes [24] and scaffolds production [25,26]. Among supercritical assisted micronization techniques, Supercritical antisolvent (SAS) precipitation has been successfully used to obtain microparticles and nanoparticles of several kinds of compounds, such as pharmaceuticals, coloring matters, polymers and biopolymers [27][28][29][30][31][32][33][34][35][36].…”

Supercritical fluids applications in nanomedicine

“…Different injection pressures were studied using two nozzle diameters (100 to 80 µm). Particles with mean diameters down to 200 nm were produced [72].…”