Polymorphic acetylation of sulphamethazine in rural bedouin and urban-dwellers in Saudi Arabia

Islam, Samira I.

doi:10.3109/00498258209052472

Cited by 11 publications

(8 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our calculated frequency of the recessive allele controlling slow acetylation (q) of 0.82 is similar to that reported from other Arab countries. The value reported from Libya was 0.81 ± 0.05 (Karim et al, 1981), that from Saudi Arabia was 0.80 ± 0.03 (Islam, 1982), while that from Egypt was 0.91 (Hashem et al, 1969). Apart from Egypt, frequencies of the recessive allele controlling slow acetylation in other Arab countries are similar to each other.…”

Section: Discussionmentioning

confidence: 63%

“…This finding is similar to results reported from other Arab countries. The frequency of slow acetylators in a sample of Saudi Arabs was found to be 63.4% using sulphadimidine (Islam, 1982), and 72.3% in another study using a caffeine metabolite (El-Yazigi etal., 1989) as test drugs. Utilizing sulphadimidine as a test drug (Karim et al, 1981), it was found that 65% of Libyan Arabs were slow acetylators.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

N‐acetylation phenotyping using dapsone in a Jordanian population.

Al-Hadidi

et al. 1991

Brit J Clinical Pharma

View full text Add to dashboard Cite

1 The N-acetylation of dapsone (DDS) was studied in 160 unrelated healthy Jordanian volunteers. 2 The frequency of slow acetylators determined using the plasma monoacetyldapsone (MADDS) to DDS ratio (MADDS/DDS), was 67.5% with a 95% confidence interval of 59 to 76%. Slow acetylators had an acetylation ratio of < 0.42. 3 Applying the Hardy-Weinberg Law, the frequency of the recessive allele controlling slow acetylation was found to be 0.82 ± 0.02. 4 The frequency distribution histogram of the plasma MADDS/DDS ratio showed an apparent trimodal pattern. The number of homozygous (n = 16) and heterozygous (n = 36) rapid acetylators derived from the observed data did not agree with those predicted for the respective rapid acetylators (n = 5 and n = 47) according to the Hardy-Weinberg Law. The suggested antimode used to discriminate the two groups was 0.82. 5 The mean plasma concentration of MADDS and the mean plasma acetylation ratio were about three times lower in slow than in rapid acetylators. However, there was no difference in mean plasma DDS concentration between slow and rapid acetylators. 6 There was a significant correlation (r = 0.853, P < 0.001) between plasma MADDS concentration and the acetylation ratio. For DDS such a correlation was absent (r = 0.059, P = 0.23).

show abstract

Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

N‐acetylation phenotyping using dapsone in a Jordanian population.

Al-Hadidi

et al. 1991

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…For example, slow-acetylating humans putatively exposed to HA carcinogens are less susceptible to colon carcinogenesis than rapid acetylators [Minchin et al, 1993;Lang et al, 1994;Hein et al, 2000]. Interestingly, several of the populations in which phenotypically slow acetylators are predominant (e.g., in Turkey, Saudi Arabia, and Egypt) are also known for a tradition of drinking coffees with a high K/C content [Islam, 1982;Bozkurt et al, 1990;Hein et al, 2000]. However, a causal relationship between acetylator phenotype and coffee drinking remains uninvestigated.…”

Section: Discussionmentioning

confidence: 99%

Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities

Huber

Teitel

Coles

et al. 2004

Environ and Mol Mutagen

View full text Add to dashboard Cite

Coffee drinking has been associated with reduced incidence of colorectal cancer, possibly via chemoprotection/modification of the metabolism of dietary heterocyclic amine carcinogens such as 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine (PhIP) by kahweol and cafestol palmitates (K/C), two components of unfiltered coffee. Using the PhIP-exposed male Fisher F344 rat as a model, K/C have been shown to reduce colonic PhIP-DNA adducts by > 50%. We have used the male F344 rat to investigate the effects of dietary K/C (0.02-0.2% as a 1:1 mixture) on the metabolism of PhIP by N-acetyltransferase- (NAT), sulfotransferase- (SULT), and glutathione-dependent pathways. K/C decreased hepatic NAT-dependent PhIP activation by up to 80% in a dose-dependent manner. Conversely, hepatic glutathione S-transferase (GST) activity/expression increased, e.g., 3-4 fold toward 1-chloro-2,4-dinitrobenzene (total activity), up to 23-fold toward 4-vinylpyridine (rGSTP1), and approximately 7-fold for rGSTA2 protein. These effects had fully developed after 5 days of the test diet and persisted for at least 5 days after withdrawal of K/C. Hepatic glutathione increased two- to threefold and this increase was more short-lived than other changes. K/C did not modify hepatic SULT activity or colon NAT and GST activities. Benzylisothiocyanate and black tea, which have also been shown to reduce the formation of PhIP-DNA adducts in this model, had little effect on hepatic NAT, SULT, GST, or GSH. In primary culture of rat hepatocytes, both kahweol and cafestol palmitates reduced NAT activity by 80%. In summary, the unique potential of K/C to convert rapid acetylators to a slow acetylator phenotype, accompanied by GST induction, might contribute to chemoprevention against cancers associated with heterocyclic amines.

show abstract

“…The frequency of slow acetylators in healthy Jordanian individuals using DDS as a test drug was 67.5% (12). The frequency of slow acetylators in Saudi Arabia was found to be 63.4% (13), in Libya was 65% (14), and in Egypt was 82% (15).…”

Section: Discussionmentioning

confidence: 93%

Acetylator Phenotype in Behçet's Disease

Najim

Sharquie

Al-Janabi

2003

The Journal of Dermatology

View full text Add to dashboard Cite

The purpose of this study was to determine the acetylator status in Behçet's disease (BD) patients and compare it to a matched group of normal individuals. Thirty-seven healthy volunteers and forty-one BD patients were included. Detailed history was taken from the patients. HLA-B51 was determined in the BD patients. In addition, the Clinical Manifestation Index (C.M.I.) was determined for each patient. Pathergy test was also done. After an overnight fast, each control subject and patient received a single oral dose of 100 mg of DDS. A blood sample was collected after 3 hours and the plasma was separated for determination of dapsone/monoacetyldapsone by HPLC. The frequency of slow acetylators in healthy individuals was 70.2%, while the frequency of rapid acetylators was 29.8%. The frequency of slow acetylators in BD patients was 53.7%, while the frequency of non-acetylators (undetected monoacetyldapsone MADDS in plasma) was 46.3%. There were no rapid acetylators among the BD patients. There was a strong negative association between the acetylator status and the severity of BD. In addition, acetylator status correlated with HLA-B51, in that BD patients with positive HLA-B51 were characterized by a very slow or non-acetylator status. Slow or non-acetylators had more severe BD. We conclude that BD patients have a unique acetylator status. This finding may have implications for the theories for the pathogenesis of the disease as well as for therapeutic aspects.

show abstract

Polymorphic acetylation of sulphamethazine in rural bedouin and urban-dwellers in Saudi Arabia

Cited by 11 publications

References 13 publications

N‐acetylation phenotyping using dapsone in a Jordanian population.

N‐acetylation phenotyping using dapsone in a Jordanian population.

Potential chemoprotective effects of the coffee components kahweol and cafestol palmitates via modification of hepatic N‐acetyltransferase and glutathione S‐transferase activities

Acetylator Phenotype in Behçet's Disease

Contact Info

Product

Resources

About