Polymorphic variants of genes ADRB2, NR3C1, MDR1 in patients with chronic obstructive pulmonary disease and obesity

Горовенко, Н. Г.; Stupnytska, Ganna; Podolskaya, S. V.

doi:10.1183/13993003.congress-2015.pa1232

Cited by 2 publications

(3 citation statements)

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“…Large number of original publications on the epidemiology, pathogenesis, diagnostics, treatment and prevention of this disease are available for review. The lead Ukrainian experts in pulmonology are actively involved in research process [1,2,[11][12][13][14][15][16][17][18]. Taking in account the majority in pulmonological disease-related publications, we can conclude that the problem of COPD in Ukraine is one of the most important in pulmonology.…”

Section: Discussionmentioning

confidence: 99%

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COPD in Ukraine: overview of the status and prospects for improvements and developments in health care system

Tolubaiev

Zaliska

Irynchyn

et al. 2015

Journal of Health Policy &Amp; Outcomes Research

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Chronic Obstructive Pulmonary Disease (COPD) is an actual problem for healthcare systems in different countries taking in account it`s high morbidity, mortality, impact on quality of life and related costs. COPD in Ukraine could be one of the most valuable medical and socio-economic problems as for developing country, the human capital affected by COPD is the most important national asset. The access to drugs is critical especially for COPD patients, medications for basic therapy are very expensive, while intended for use permanently. This study was performed to investigate the status with COPD in Ukraine and determine possible ways for improvements and developments in COPD management and related processes in healthcare system in Ukraine. The following areas were investigated: epidemiological data, data in COPD management, health economics data and targeted literature review. Results showed that very limited epidemiological COPD data are available in Ukraine. There are favorable conditions for good COPD management in Ukraine because of availability of the adopted guidance and the unified clinical protocol that cover prophylaxis, diagnostics, treatment and rehabilitation of COPD patients. Ukrainian clinical guidance in COPD management has external validity and is expected to be updated on regular basis. There were several country-specific Health Economic studies focused on COPD but these studies have limitations due to substantial assumptions and extrapolations from small to large populations. More Health Economics large-scale studies needs to be performed in Ukraine. Results of current study, also, showed that COPD is a relevant topic for pulmonology research in Ukraine.

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Section: Discussionmentioning

confidence: 99%

“…N. Gorovenko et al investigated the polymorphic marker for of adrb2, nr3c1, mdr1 genes relation with improvement of ICS/LABA therapy effect in COPD patients. Method could be used for prediction of ICS/ LABA treatment efficiency in COPD patients [14].…”

Section: -2015 Publications In Ukrainian Pulmonology Journalmentioning

confidence: 99%

COPD in Ukraine: overview of the status and prospects for improvements and developments in health care system

Tolubaiev

Zaliska

Irynchyn

et al. 2015

Journal of Health Policy &Amp; Outcomes Research

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“…Various results have been obtained regarding the dependence of this polymorphism on obesity development (Zhang et al, 2014;Saliba et al, 2014;Aplalasamy et al, 2015;Leonska-Duniec et al, 2016). In our previous studies the association of the ADRB2 gene polymorphic variant C79G (rs1072714) with the development of obesity in COPD patients was shown (Gorovenko et al, 2014;Gorovenko et al, 2015). In this work we studied the CAT test and the integral BODE index of COPD patients with and without obesity depending on the ADRB2 gene polymorphic variant C79G (rs1072714).…”

Section: Source: Authorsmentioning

confidence: 94%

ASSOCIATION OF THE ADRB2 GENE POLYMORPHIC VARIANT C79G (rs1072714) WITH THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OBESE AND NON-OBESE PATIENTS

Stupnytska

Горовенко

Podolska

et al. 2018

CBUP

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Introduction: Attention has been paid to studying the role of the sympathetic nervous system and polymorphism of the β2-adrenoceptor genes in the development of chronic obstructive pulmonary disease (COPD) in recent years, but the findings of the studies contradict each other.Objective: To establish an association between the ADRB2 gene polymorphic variant C79G (rs1072714) in obese and non-obese COPD patients.Methods: The study involved 48 obese COPD patients and 52 nonobese COPD patients. The ADRB2 gene polymorphic variant C79G (rs1072714) was genotyped and assessed by the CAT test and the BODE index.Results: It has been established that in obese COPD patients the CAT test was significantly higher in the genotype GG (24.25 ± 4.25) compared to those with obesity and the genotype CC and CG (p <0.05). The BODE index was significantly (p <0.05) lower in obese COPD patients. A strong positive correlation between BMI and FEV1 (r = 0.742, p = 0.014) in nonobese COPD patients with GG genotype has been found.Conclusion: According to the CAT test, the quality of life in obese COPD patients with GG genotype is worse. The BODE index in obese COPD patients with CC and CG genotypes was significantly lower than in those without obesity. A strong positive correlation between BMI and FEV1 in COPD patients without obesity with GG genotype has been established.

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Polymorphic variants of genes ADRB2, NR3C1, MDR1 in patients with chronic obstructive pulmonary disease and obesity

Cited by 2 publications

References 0 publications

COPD in Ukraine: overview of the status and prospects for improvements and developments in health care system

COPD in Ukraine: overview of the status and prospects for improvements and developments in health care system

ASSOCIATION OF THE ADRB2 GENE POLYMORPHIC VARIANT C79G (rs1072714) WITH THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN OBESE AND NON-OBESE PATIENTS

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