Polymorphism G1359A of the cannabinoid receptor gene (<scp>CNR</scp>1): allelic frequencies and influence on cardiovascular risk factors in a multicentre study of Castilla‐Leon

Luis, Daniel Antonio de; Ballesteros, María Rosa Albañil; Guzman, A. Lopez; Ruiz, Enrique Martínez; Muñoz, Carmen; Penacho, M.A.; Iglesias, Pedro; Martín, Luis Rodrigo; Izaola, Olatz; Delgado, Manuel

doi:10.1111/jhn.12297

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Overall, 22 positive associations with lipid levels were seen. The mutant allele of CB 1 SNP rs1049353 was associated with higher HDL and lower TGs in three cohorts, as well as with lower TGs in two populations (n = 808) (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…FAAH SNPs rs324420 and rs3123554 were associated with higher TG levels in European cohorts ( P < 0.05; n = 1644) (Table ). FAAH SNP rs324420 was also associated with raised anandamide levels in a Brazilian population ( P < 0.05; n = 200) …”

Section: Resultsmentioning

confidence: 99%

“…The literature showed 13 associations between rs1049353 and reductions in parameters of glucose metabolism 4,7,10,[12][13][14]16,17,[19][20][21][22][23] ( Figure 1). This suggests that this SNP is important in diabetic phenotypes, probably caused by upregulation of gluconeogenic transcription factors as the result of increased CB 1 receptor activity.…”

Section: Discussionmentioning

confidence: 99%

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Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Doris

Millar

Idris

et al. 2018

Diabetes Obesity Metabolism

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The endocannabinoid system (ECS) is involved in many physiological processes including fertility, pain and energy regulation. The aim of this systematic review was to examine the contribution of single nucleotide polymorphisms (SNPs) of the ECS to adiposity and glucose metabolism. Database searches identified 734 articles, of which 65 were included; these covered 70 SNPs in genes coding for cannabinoid receptors 1 and 2 (CB , CB ), fatty acid amide hydrolase (FAAH) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD). No studies included SNPs relating to monoacylglycerol lipase or diacylglycerol lipase. The CB receptor SNP rs1049353 showed 17 associations with lower body mass index (BMI) and fat mass (five studies). It also showed three associations with lower insulin levels (one study). Conversely, the CB receptor SNP rs806368 was associated with increased BMI and waist circumference (two studies). The FAAH SNP rs324420 was associated with increased obesity (three studies). A haplotype of NAPE-PLD was associated with decreased BMI (one study). A total of 60 SNPs showed no association with any measured outcome. This review suggests a complex but important role of ECS SNPs in energy and glucose metabolism.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genetic polymorphisms of the endocannabinoid system in obesity and diabetes

Doris

Millar

Idris

et al. 2018

Diabetes Obesity Metabolism

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“…A silent intragenic biallelic polymorphism in codon 435 of the cannabinoid receptor 1 (CNR1) gene, substitution of G to A at nucleotide position 1359 (1359 G/A rs1049353), was reported to be associated with several disorders like obesity [3], type 2 diabetes mellitus [4], and metabolic syndrome [5]. It is a common polymorphism among different populations, as the frequency of the rare allele (A) carriers was reported to be 24-32% in German [6] and 48.1% in Spanish [7] populations. Earlier studies reported an association of A-allele (mutant allele) with better anthropometric measurements [8], metabolic profile [3,7] and adipokines [9] compared to non-A allele carriers (wild type allele).…”

Section: Introductionmentioning

confidence: 99%

“…It is a common polymorphism among different populations, as the frequency of the rare allele (A) carriers was reported to be 24-32% in German [6] and 48.1% in Spanish [7] populations. Earlier studies reported an association of A-allele (mutant allele) with better anthropometric measurements [8], metabolic profile [3,7] and adipokines [9] compared to non-A allele carriers (wild type allele). However, other studies failed to find such associations [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

G1359A Variant of the Cannabinoid Receptor Gene (rs1049353) and Obesity-Related Traits and Related Endophenotypes: A Meta-Analysis

2018

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Background: This study aimed to investigate the comparison of G1359A variant of cannabinoid receptor gene (rs1049353) with obesity-related traits including body mass index (BMI), fat mass (FM), fat-free mass (FFM), food-related traits, and leptin among healthy and non-healthy adults. Methods: We searched PubMed, Cochrane, Scopus, Web of Science, and EMBASE until December 2016 for observational studies assessing each of the anthropometric measurements, food-related traits, and leptin of 1359 G/A polymorphism of CNR1 gene. A total of 22 studies were included in the meta-analysis comparing mean and SD differences of the anthropometric measurements, leptin, and dietary intake between GA/AA and GG genotypes. Results: The results showed that subjects with GA/AA genotype had significantly lower BMI (weighted mean difference = –0.59 kg/m², p < 0.001) compared to those with the GG genotype. Dietary intake of fat, carbohydrate, and protein as well as serum levels of leptin was not significantly different between GA/AA and GG genotypes. Conclusion: It was revealed that subjects with mutant polymorphism (GA/AA) of CNR1, compared to the wild-type group (GG), had lower BMI (although there was unexplained heterogeneity).

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