Polymorphism in the vitamin D receptor gene is associated with maternal vitamin D concentration and neonatal outcomes: A Brazilian cohort study

Pereira, Marcos; Carvalho, Gisele Queiroz; Louro, Iúri Drumond; Santos, Djanilson Barbosa dos; Oliveira, Ana Mayra Andrade de

doi:10.1002/ajhb.23250

Cited by 14 publications

(10 citation statements)

References 17 publications

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“…Hence, the VDR polymorphism may be a protective or risk factor for adverse events, according to the genetic profile of the woman. 27 Our head circumference findings were similar to those of several other studies conducted in subtropical or tropical countries that demonstrated no correlation with umbilical cord blood vitamin D level. 13,[18][19][20] This study had several limitations.…”

Section: Discussionsupporting

confidence: 90%

Correlation of Maternal Prenatal Vitamin D Level with Postnatal Infant Growth in Length and Head Circumference: A Cohort Study on Vitamin D Status and Its Impact During Pregnancy and Childhood in Indonesia

Noviandhari¹,

Faisal²,

Dhamayanti³

2022

IJGM

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Objective To determine the correlation of first trimester maternal 25-(OH)-D level with postnatal infant growth in Indonesia. Materials and Methods A cohort of 116 mother–infant pairs from Indonesia was prospectively studied. 25-(OH)-D level was measured in maternal serum at 10–14 weeks of gestation and in umbilical cord blood shortly after birth. The newborns were observed longitudinally for 24 months. Length and head circumference were measured at birth and at ages 3, 6, 12, and 24 months. Spearman correlation and multiple linear regression analyses were performed. Results Mean 25-(OH)-D levels in the prenatal maternal serum and umbilical cord blood were 17.55 ± 7.33 ng/mL and 16.27 ± 6.14 ng/mL, respectively. Prenatal maternal 25-(OH)-D level weakly correlated with infant length (r = −0.35) and head circumference (r = –0.21) z-scores at age 3 months. Umbilical cord blood 25-(OH)-D level did not correlate with infant length or head circumference at any time point. Multiple linear regression showed an independent association between prenatal maternal 25-(OH)-D level and infant length z-score at age 3 months (p = 0.01, SE β = 0.02, and coefficient β = −0.06). Conclusion First trimester maternal serum 25(OH)D level correlated with infant length and head circumference at age 3 months.

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Section: Discussionsupporting

confidence: 90%

Correlation of Maternal Prenatal Vitamin D Level with Postnatal Infant Growth in Length and Head Circumference: A Cohort Study on Vitamin D Status and Its Impact During Pregnancy and Childhood in Indonesia

Noviandhari¹,

Faisal²,

Dhamayanti³

2022

IJGM

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“…Vitamin D metabolism may be influenced by single nucleotide polymorphisms of VDR genes such as BsmI, FokI, TaqI, and ApaI, possibly contributing to premature birth. A Brazilian cohort study found that maternal homozygotes with the low-frequency (CD) allele of ApaI single nucleotide polymorphism may be at increased risk of preterm birth [23]. Therefore, the VDR should be considered when exploring the impact of 25(OH) D on premature delivery.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Status in Pregnant Women in Southern China and Risk of Preterm Birth: A Large-Scale Retrospective Cohort Study

Guo

et al. 2019

Med Sci Monit

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Departmental sources Background: The influence of maternal vitamin D on pregnancy outcomes, including preterm birth (PTB), is unclear due to different experimental designs and study populations (patient race and sample size) of previous studies. We aimed to investigate the relationship between 25-hydroxyvitamin D (25[OH] D) levels and PTB among pregnant women in southern China. Material/Methods: A total of 11 641 pregnant women were retrospectively enrolled between January 2016 and April 2019. Vitamin D concentrations were evaluated by electrochemiluminescence immunoassay. Logistic regression analysis was used to analyze the association between vitamin D and PTB. Results: The average 25(OH) D concentration was 59.3±21.5 nmol/L; 34.8% of patients were vitamin D deficient, 43.0% were vitamin D insufficient (25[OH] D <50 nmol/L and 50-74.9 nmol/L, respectively). In total, 3.6% of newborns were born prematurely. Comparing the pre-term and full-term groups, 45.7% versus 42.9% and 29.8% versus 35% were vitamin D deficient and insufficient, respectively These differences were not significant (P>0.05). However, the mean vitamin D status was significantly different between the pre-term and full-term groups (61.3±21.3 and 59.1±21.5 nmol/L, respectively). No association was found between vitamin D deficiency/insufficiency and PTB in unadjusted or adjusted models, compared with vitamin D sufficiency (adjusted odds ratio, 1.016; 95% confidence interval, 0.794-1.301 and 0.842; 0.641-1.106, respectively). Conclusions: Low maternal 25(OH) D levels are common in southern China. However, low vitamin D status in pregnant women appears to be unrelated to PTB. Measuring vitamin D level alone is therefore not sufficient to predict PTB.

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“…They also investigated the vitamin D levels’ association with the VDR gene’s BsmI , ApaI , and TaqI polymorphisms and their haplotypes’ distribution and their wild genotypes, and the GGT ( BAT ) haplotype correlated with lower 25(OH)D serum levels [ 92 ]. A cohort study by Pereira-Santos et al (2019) [ 93 ], with 270 pregnant women living in northeastern Brazil, evaluated the associations between VDR gene polymorphisms, maternal 25(OH)D concentration, and gestational outcomes. They found that participants with the VDR Taq I’s tt genotype had a higher 25(OH)D concentration during gestation; the children of women with the VDR Apa I SNP’s Aa genotype were born with a lower weight; women with VDR Taq I SNP’s Tt genotype decreased the risk of a shorter gestation duration; while women with VDR Apa I SNP’s aa genotype were negatively affected and had decreased gestation duration.…”

Section: Discussionmentioning

confidence: 99%

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

et al. 2023

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(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.

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Polymorphism in the vitamin D receptor gene is associated with maternal vitamin D concentration and neonatal outcomes: A Brazilian cohort study

Cited by 14 publications

References 17 publications

Correlation of Maternal Prenatal Vitamin D Level with Postnatal Infant Growth in Length and Head Circumference: A Cohort Study on Vitamin D Status and Its Impact During Pregnancy and Childhood in Indonesia

Correlation of Maternal Prenatal Vitamin D Level with Postnatal Infant Growth in Length and Head Circumference: A Cohort Study on Vitamin D Status and Its Impact During Pregnancy and Childhood in Indonesia

Vitamin D Status in Pregnant Women in Southern China and Risk of Preterm Birth: A Large-Scale Retrospective Cohort Study

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

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