Polymorphism of growth hormone receptor (GHR) gene in Nilagiri sheep

Sahu, Amiya Ranjan; Jeichitra, V.; Rajendran, R.; Amri, R.

doi:10.1007/s11250-016-1189-0

Cited by 6 publications

(2 citation statements)

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“…Seventeen mutations have been reported in GHRHR , and these mutations will lead to severe growth disorders in patients [ 40 ]. At present, there are few studies on the association between SNP of GH , GHR, and GHRHR with sheep growth traits, and only one breed of sheep was tested and analyzed [ 18 , 19 , 20 , 21 , 22 , 41 , 42 ]. The association between InDel of GH and sheep growth has only been reported in Luxi Blackhead sheep [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Novel InDels of GHR, GHRH, GHRHR and Their Association with Growth Traits in Seven Chinese Sheep Breeds

Zhao

Tang

et al. 2020

Animals

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The GH growth axis plays an important role in the growth and development of animals and runs through the whole life of animals. Many studies have shown that molecular mutations in key genes of the GH axis will affect the growth and development of animals. The purpose of this study was to explore the distribution characteristics of InDels of GHR, GHRH, and GHRHR in seven Chinese sheep populations, and to further explore the relationship between InDels and sheep growth traits. GHR showed high variation in Chinese sheep, and GHR-53 showed the highest minimum allele frequency (MAF). There was only one InDel mutation site in both GHRH and GHRHR. The genotype frequencies of Hu sheep (HS), Tong sheep (TS), and Lanzhou fat-tail sheep (LFTS) were quite different from other breeds. The association between GHR, GHRH, and GHRHR InDels and body size traits in seven varieties were analyzed. The results showed that there was no significant relationship between GHRH and body size traits in the seven sheep populations. There was a positive association between GHR-21 and hip height of LFSH (p < 0.05). GHR-43 reduced body height and chest depth of Small tail han sheep (STHS) and hip width of TS. GHR-44 significantly affected the body weight of HS, the body height of STHS and the head depth of TS. GHR-53 significantly reduced cannon girth of HS, chest of STHS and forehead width of TS. GHRHR-2 significantly reduced the body weight of LFHS. To sum up, this study revealed the effects of GHR, GHRH, and GHRHR InDels on sheep phenotypic traits, which indicated their potential application prospects in the genetic improvement of mutton sheep.

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Section: Discussionmentioning

confidence: 99%

Novel InDels of GHR, GHRH, GHRHR and Their Association with Growth Traits in Seven Chinese Sheep Breeds

Zhao

Tang

et al. 2020

Animals

View full text Add to dashboard Cite

show abstract

“…The GH gene encodes the growth hormone which, through its specific receptor (Sahu et al, 2017), is the major regulator of IGF-I synthesis in the liver (Teran et al, 2016). IGF-1 is the main mediator of the effects of the growth hormone on muscle and bone tissues.…”

Section: Introductionmentioning

confidence: 99%