Polymorphism of stabilized and nonstabilized tristearin, pure and in the presence of food emulsifiers

Elisabettini, Paola; Desmedt, Arnaud; Durant, François

doi:10.1007/bf02523893

Cited by 32 publications

(35 citation statements)

References 11 publications

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“…The specific XRD lines (0.46, 0.39, and 0.37 nm with WAXS and 4.49 nm with SAXS) for the β form of FHCO in the current study were similar to the previous findings in the case of tristearin ( Figure S4 in the Supporting Information). 35,36 The thermogram patterns of FHCO blended with LCO in various weight ratios would be similar to the pattern of FHCO, which comprised a melting peak of the β form and a crystallization peak of the α form (Figure 5b−d). However, the T m and T c of the β-and α-polymorphic forms for each blended lipid differed from those for FHCO (Table 2).…”

Section: ■ Results and Discussionmentioning

confidence: 91%

Enhancing the Stability of Lipid Nanoparticle Systems by Sonication during the Cooling Step and Controlling the Liquid Oil Content

Ban¹,

Lim

Chang³

et al. 2014

J. Agric. Food Chem.

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Aggregation of unstable particles in water limits the application of lipid nanoparticle (LNP) systems to foods despite the capability to encapsulate lipophilic bioactive components. This study exploits a preparation process that can reduce the aggregation of LNPs. Sonication during the cooling step (postsonication) for 4, 5, or 6 min was applied to increase the covering effect of Tween 20 on the particle. Additionally, LNPs were prepared using fully hydrogenated canola oil (FHCO) blended with 0-30 wt % liquid canola oil (LCO) of the lipid phase. Surfactant surface load data indicate that the postsonication might make nonemulsifying Tween 20 diffuse from the aqueous phase to droplet surfaces, which could decrease the crystallinity index (CI) of LNPs due to the inhibition of lipid crystallization. Moreover, the LCO content in lipid matrix could decrease the CI, which could reduce the formation of hydrophobic patches on the particle surface. Therefore, the postsonication and the LCO addition in the matrix could effectively prevent aggregation among hydrophobic patches. This improved colloidal stability of LNPs was verified by the particle shape in transmission electron microscopy and the gelation test. Consequently, LNPs fabricated using 6 min postsonication and 30 wt % LCO in the lipid exhibited the greatest stability (size, 202.3 nm; CI, 57.5%; Tween 20 surface load, 10.29 mg m(-2)). This study may serve as a basis for further research that aims to develop delivery systems for functional foods.

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Section: ■ Results and Discussionmentioning

confidence: 91%

Enhancing the Stability of Lipid Nanoparticle Systems by Sonication during the Cooling Step and Controlling the Liquid Oil Content

Ban¹,

Lim

Chang³

et al. 2014

J. Agric. Food Chem.

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show abstract

“…Tristearin crystallization has been extensively studied because of its importance to the fatty acid/triglyceride community [38], but there has been little research on the effect of tristearin crystallization on drug delivery [39]. It is known that changes in forms of tristearin occur, which may be related to tristearin crystallization from bupivacaine-fb [40,41,42].…”

Section: Resultsmentioning

confidence: 99%

Solid-state NMR studies of pharmaceutical solids in polymer matrices

Lubach

Padden

Winslow

et al. 2004

Analytical and Bioanalytical Chemistry

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Biodegradable drug-delivery systems can be formulated to release drug for hours to years and have been used for the controlled release of medications in animals and humans. An important consideration in developing a drug-delivery matrix is knowledge of the long-term stability of the form of the drug and matrix after formulation and any changes that might occur to the drug throughout the delivery process. Solid-state NMR spectroscopy is an effective technique for studying the state of both the drug and the matrix. Two systems that have been studied using solid-state NMR spectroscopy are presented. The first system studied involved bupivacaine, a local anesthetic compound, which was incorporated into microspheres composed of tristearin and encapsulated using a solid protein matrix. Solid-state 13C NMR spectroscopy was used to investigate the solid forms of bupivacaine in their bulk form or as incorporated into the tristearin/protein matrix. Bupivacaine free base and bupivacaine-HCl have very different solid-state NMR spectra, indicating that the molecules of these compounds pack in different crystal forms. In the tristearin matrix, the drug form could be determined at levels as low as 1:100 (w/w), and the form of bupivacaine was identified upon loading into the tristearin/protein matrix. In the second case, the possibility of using solid-state 13C NMR spectroscopy to characterize biomolecules lyophilized within polymer matrices is evaluated by studying uniformly 13C-labeled asparagine (Asn) in 1:250 (w/w) formulations with poly(vinyl pyrrolidone) (PVP) and poly(vinyl alcohol) (PVA). This work shows the capability of solid-state NMR spectroscopy to study interactions between the amino acid and the polymer matrix for synthetic peptides and peptidomimetics containing selective 13C labeling at the Asn residue.

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“…Tristearin was chosen as a model TG as it has been well-characterized with XRD and DSC (Larsson, 1966;Lutton, 1972;Simpson and Hagemann, 1982;Aronhime et al, 1987;Hagemann, 1988;Elisabettini et al, 1996;Oh et al, 2002;MacNaughtan et al, 2006) and its polymorphs are easy to prepare.…”

Section: Introductionmentioning

confidence: 99%

Characterization of the three major polymorphic forms and liquid state of tristearin by Raman spectroscopy

Silva

Bresson

Rousseau

2009

Chemistry and Physics of Lipids

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Polymorphism of stabilized and nonstabilized tristearin, pure and in the presence of food emulsifiers

Cited by 32 publications

References 11 publications

Enhancing the Stability of Lipid Nanoparticle Systems by Sonication during the Cooling Step and Controlling the Liquid Oil Content

Enhancing the Stability of Lipid Nanoparticle Systems by Sonication during the Cooling Step and Controlling the Liquid Oil Content

Solid-state NMR studies of pharmaceutical solids in polymer matrices

Characterization of the three major polymorphic forms and liquid state of tristearin by Raman spectroscopy

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