Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Mak, Judith C.W.; Ho, Stanley; Yu, Wai Cho; Choo, Kahlin; Chu, Chung Ming; Ww, Yew; Lam, Wayne; Chan‐Yeung, Moira

doi:10.1183/09031936.00015207

Cited by 51 publications

(46 citation statements)

References 26 publications

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“…Consistent with our result, a study in erythrocyte red blood cells showed decreased CAT activity in patients with COPD [35,36]. In contrast, a study on single nucleotide polymorphism in CAT gene (-262 C > T) showed that erythrocyte catalase activity was higher in COPD patients with the C/C genotype, and with the combined C/T and T/T genotypes, than in healthy controls [37]. Our study supports the finding of Tavilani et al, which reported an increase in SOD and CAT activities in alveolar macrophages of elderly smokers [38].…”

Section: Discussionsupporting

confidence: 90%

“…However, we found a dramatic increase in SOD and CAT activities among patients with more severe COPD. It was found that erythrocyte SOD and CAT activities gradually increased from GOLD stages I to IV in COPD patients, which is supported by previous reports [36][37][38][39][40][41]. Indeed, various studies [40][41][42] except one study [7] have suggested that certain markers of oxidative stress may be related to tobacco smoking or to the severity of COPD.…”

Section: Discussionsupporting

confidence: 73%

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Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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Background: Oxidative stress has been suggested in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD) with an additional burden of diabetes, hypertension and cardiovascular disease. In the present study, we investigated erythrocyte antioxidant enzymes activities in correlation to COPD severity and COPD comorbidities. Methods: One hundred twenty seven subjects with COPD and 59 healthy controls participated in this study. COPD severity was done based on the Global Initiative for Chronic Obstructive Lung Disease criteria. The erythrocytes enzyme activities of superoxide dismutase (SOD), catalase (CAT), glutathione-s-transferase (GST), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status (TAS) were measured with spectrophotometric method. Results: COPD patients showed significant decrease in TAS (p > 0.05), GST (p < 0.001) and GPx (p < 0.01) activities with progression of the disease. In patients, FEV 1 was negatively correlated with SOD, GR and positively correlated with GST and GPx activities. Further, multivariate logistic regression analysis revealed GST (OR = 0.93; 95% CI = -0.10 -0.01; p < 0.01) , GPx (OR = 0.98; 95% CI = -0.03 -0.00; p < 0.05) and TAS (OR = 0.95; 95% CI = -0.08 -0.00; p < 0.05) were independently associated with FEV 1 in GOLD stage IV and GST (OR = 1.11; 95% CI = 0.04-0.18; p < 0.001) in GOLD stage II. Regression analysis confirmed a significant difference in GPx activity in COPD -type 2 diabetes (OR = 0.04; 95% CI = -6.60 -0.53; P = 0.09), and GST activity in COPD -cardiovascular disease (OR = 2.51; 95% CI = 0.00 -1.84; p < 0.05) patients when compared to patients without comorbidities. Conclusion: A significant decline in lung function may be associated with altered antioxidant enzyme activity due to the strong correlation between GST and GPx with COPD severity. Our results also indicate that erythrocytes GST and GPX activities are significantly associated with comorbidities, but only in COPD patients with type 2 diabetes and cardiovascular disease.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 73%

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Asimuddin

Gutta

Ansari³

et al. 2017

COPD Res Pract

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“…An association of the Ala16Val SNP was not found neither with the presence of COPD nor with lung function decline, which is in concordance with results of two previous studies performed [18,19].…”

Section: Sod Genetics In Copd and Bhr M Siedlinski Et Alsupporting

confidence: 91%

“…Ala16Val, which is localised in a protein signal sequence, and thus possibly has a functional role [12][13][14]. This substitution has been associated with a higher lung cancer risk in Caucasians [15][16][17] but not with the presence of COPD in Caucasian and Chinese smokers [18,19]. SOD3 contains three nonsynonymous SNPs, i.e.…”

mentioning

confidence: 99%

Superoxide dismutases, lung function and bronchial responsiveness in a general population

Siedliński¹,

Diemen

Postma

et al. 2009

Eur Respir J

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Oxidative stress is an important causative factor in the onset and progression of smoking-related lung diseases, such as chronic obstructive pulmonary disease (COPD). Superoxide dismutases (SODs) can prevent an increase in oxidative burden.A total of 1,390 subjects from the prospective Vlagtwedde-Vlaardingen cohort were genotyped for two single nucleotide polymorphisms (SNPs) in SOD2 and four SNPs in SOD3, which were further analysed for associations with the presence of bronchial hyperresponsiveness (BHR; provocative concentration causing a 10% fall in the forced expiratory volume in one second (FEV1; PC10 f8 mg?mL -1 of histamine), COPD (defined as Global Initiative for Chronic Obstructive Lung Disease stage II or higher), lung function level and the longitudinal course of FEV1.The intronic C5774T SNP of SOD2 was significantly associated with the presence of COPD and BHR in the total population. The T/T genotype for this polymorphism and the Val/Val genotype for the SOD2 Ala16Val substitution were risk factors for BHR in individuals without COPD. The SOD3 Arg213Gly substitution was associated with slower FEV1 decline in never-smokers exclusively, and the SOD3 G(-4466)T SNP was associated with a lower vital capacity level.Both SOD2 polymorphisms are associated with bronchial hyperresponsiveness, a risk factor for chronic obstructive pulmonary disease, while SOD2 C5774T additionally confers a risk for chronic obstructive pulmonary disease in the total population. The current authors furthermore confirm previously reported associations of SOD3 single nucleotide polymorphisms with lung function in the general population.

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“…Various inflammatory and structural cells in the airways have been reported to generate increased amounts of ROS [2]. The lungs have developed several endogenous antioxidant systems to deal with the production of free radicals [3]. Superoxide dismutase (SOD) catalyses the dismutation of O 2 ⋅ -to H 2 O 2 and oxygen (O 2 ), while catalase (CAT) decomposes H 2 O 2 to water and oxygen.…”

Section: Original Papersmentioning

confidence: 99%

Gene Polymorphisms of Tumor Necrosis Factor Alpha and Antioxidant Enzymes in Bronchial Asthma

Despotović¹,

Stoimenov²,

Stanković³

et al. 2015

Adv Clin Exp Med

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Background. Bronchial asthma is an inflammatory disease resulting from a combination of genetic and environmental factors. Single nucleotide polymorphisms in the regulatory regions of cytokine and antioxidant enzyme genes may affect cytokine production and enzyme activity, and thus play a contributory role in asthma pathogenesis. Objectives. The aim of this study was to examine the association of manganese superoxide dismutase (MnSOD) Ala16Val, catalase (CAT) A-21T and tumor necrosis factor alpha (TNF-α) G-308A polymorphisms with bronchial asthma. Material and Methods. A total of 79 patients with asthma and 95 healthy controls were screened for MnSOD Ala16Val, CAT A-21T and TNF-α G-308A polymorphisms using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

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Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD

Cited by 51 publications

References 26 publications

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

Superoxide dismutases, lung function and bronchial responsiveness in a general population

Gene Polymorphisms of Tumor Necrosis Factor Alpha and Antioxidant Enzymes in Bronchial Asthma

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