Polymorphisms in the interleukin 17F gene (IL17F) and asthma

Abstract

Interleukin17F (IL17F) is a regulatory cytokine for T-cell-mediated immune responses. The gene coding for IL17F (IL17F) is located on chromosome 6p, a genomic region linked to asthma and asthma-related phenotypes in multiple genome scans. IL17F is expressed in lung tissue, in bronchoalveolar lavage fluid from asthmatic subjects, and in activated CD4 þ cells. We were thus interested in testing for association between single-nucleotide polymorphisms (SNPs) and haplotypes in IL17F and asthma. To characterize polymorphisms in IL17F, we sequenced this gene in a group of African Americans and a group of European Americans. A total of 50 SNPs (30 not previously reported in a public database (dbSNP build 118)) and two insertions/deletions were detected in IL17F; five of these polymorphisms were genotyped in participants of the Nurses' Health Study. We then tested for association between SNPs and haplotypes in IL17F and physician-diagnosed asthma in subjects with (cases) and without (control subjects) physician-diagnosed asthma. None of the SNPs or haplotypes tested in IL17F were associated with asthma. The polymorphisms identified in this study may be used in future studies of association between IL17F and phenotypes related to immune responses.

Genetic polymorphism of interleukin-17A and -17F genes in gastric carcinogenesis

“…In addition, it has been shown that this variant is functional in vivo, and that it influences asthma susceptibility. The other study by Ramsey et al, using 1027 Caucasian female subjects, found no association between asthma and IL-17F polymorphisms [28]. This discrepancy may be a result of the facts that the frequency of IL-17F/7488C allele was lower in the European American subjects (4.5%) than in the healthy Japanese subjects (11.4%).…”

IL-17F sequence variant (His161Arg) is associated with protection against asthma and antagonizes wild-type IL-17F activity

“…In a recent study by Ramsey et al, 18 relationships between asthma and IL17F polymorphisms (including the H161R variant) were examined using 1027 white female subjects. The study found no associations between asthma and IL17F polymorphisms.…”

Significant Association between <i>IL-17F</i> Promoter Region Polymorphism and Susceptibility to Asthma in a Korean Population

“…A negative association between the rs763780 SNP and atopic dermatitis or psoriasis vulgaris was reported in a Japanese population [14]. Ramsey et al [9] failed to find any association between polymorphisms of the IL-17F gene and asthma. In contrast, however, Kawaguchi et al [10] found a positive association between the rs763780 SNP in exon 3 and asthma.…”

“…A number of polymorphisms in the IL-17F gene have recently been identified in an African American group, a European American group and a Japanese group [9,10]. Furthermore, association studies between IL-17F polymorphisms and asthma have been conducted in these groups.…”