Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele

Chen, Shiou-Sheng; Chang, Luke S.; Chen, Haw‐Wen; Wei, Yau‐Huei

doi:10.1093/humrep/17.3.718

Cited by 71 publications

(65 citation statements)

References 41 publications

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“…Recently, the nuclear encoded proteins including mitochondrial-specific DNA polymerase gamma (POLG) [144] and glutathione S-transferase M1 have been reported to be involved in male infertility [145]. POLG is responsible for replication and repair of the mtDNA.…”

Section: The Usp26 Gene Mutationsmentioning

confidence: 99%

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

Tahmasbpour

Balasubramanian

Agarwal

2014

J Assist Reprod Genet

109

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Background The assisted reproductive techniques aimed to assist infertile couples have their own offspring carry significant risks of passing on molecular defects to next generations. Results Novel breakthroughs in gene and protein interactions have been achieved in the field of male infertility using genome-wide proteomics and transcriptomics technologies. Conclusion Male Infertility is a complex and multifactorial disorder.Significance This review provides a comprehensive, up-todate evaluation of the multifactorial factors involved in male infertility. These factors need to be first assessed and understood before we can successfully treat male infertility.

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Section: The Usp26 Gene Mutationsmentioning

confidence: 99%

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

Tahmasbpour

Balasubramanian

Agarwal

2014

J Assist Reprod Genet

109

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“…Aydemir et al [42] reported that the frequency of increased oxidative damage for sperm and seminal plasma in the male population with idiopathic infertility is higher in patients with a GSTM1-null genotype, although no significant differences were found in the distribution of the GSTM1 variant genotype between idiopathic infertile subjects and fertile subjects. Chen et al [27] reported that the frequency of sperm mitochondrial DNA damage in infertility patients with varicocele is higher in those with a GSTM1-null genotype, although the frequency of the GSTM1-null genotype did not differ between the varicocele group and the controls.…”

Section: Discussionmentioning

confidence: 98%

“…These polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases, including malignancy [18][19][20][21][22][23][24][25], although the relationship between polymorphisms and male infertility remains to be elucidated [26,27]. We therefore speculated that individual susceptibility to varicocele-induced ROS may depend on one or more of these genetic polymorphisms and that the outcome of varicocelectomy may be influenced by an individual's genetic susceptibility to ROS.…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

Ichioka¹,

Nagahama²,

Okubo³

et al. 2009

Asian J Androl

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Glutathione S-transferases (GSTs), superoxide dismutase 2 (SOD2) and NAD(P)H:quinone oxidoreductase 1 (NQO1) are anti-oxidant enzyme genes. Polymorphisms of GSTs, SOD2 and NQO1 have been reported to influence individual susceptibility to various diseases. In an earlier study, we obtained preliminary findings that a subset of glutathione S-transferase T1 (GSTT1)-wt patients with varicocele may exhibit good response to varicocelectomy. In this study, we extended the earlier study to determine the distribution of genotype of each gene in the infertile population and to evaluate whether polymorphism of these genes affects the results of surgical treatment of varicocele. We analyzed 72 infertile varicocele patients, 202 infertile patients without varicocele and 101 male controls. Genotypes of GSTs were determined by polymerase chain reaction (PCR). Genotyping of SOD2 and NQO1 was performed using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. A significantly better response to varicocelectomy was found in patients with the GSTT1-wt genotype (63.2%) and NQO1-Ser/Ser genotype (80.0%) than in those with GSTT1-null genotype (35.3%) and NQO1-Pro/Pro or NQO1-Pro/Ser genotype (45.2%), respectively. The frequencies of glutathione S-transferase M1/T1, SOD2 and NQO1 genotypes did not differ significantly among the varicocele patients, idiopathic infertile patients and male controls. GSTT1 genotype is associated with improvement of semen parameters after varicocelectomy. As the number of patients with NQO1-Ser/Ser genotype was not sufficient to reach definite conclusions, the association of NQO1 genotype with varicocelectomy requires further investigation.

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“…Like SOD1, glutathione Stransferases are a family of cytosolic and mitochondrial enzymes that function in the removal of oxidative species from cells. Deletions in the glutathione S-transferase M1 (GST-M1) and GST-T1 enzymes in men with varicocele have been associated with impaired sperm motility and elevated levels of 8-hydroxy-2′-deoxyguanosine in sperm DNA, a marker of DNA damage [38,39]. Certain genetic lesions disrupt the balance of pro-and antioxidant species in cells.…”

Section: Oxidative Stressmentioning

confidence: 99%

Molecular mechanisms involved in varicocele-associated infertility

Sheehan

Ramasamy

Lamb

2014

J Assist Reprod Genet

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Varicocele is a pathologic enlargement of the pampiniform venous plexus within the spermatic cord, a condition that is a common cause of impaired sperm production and decreased quality of sperm. While varicocele is the most common surgically correctable risk factor for male infertility, not all males with varicocele experience infertility. In fact, most men with varicocele have normal spermatogenesis. Despite its prevalence, the molecular mechanisms of varicocele and its effect on testicular function are yet to be completely understood. We postulate that men with varicocele-associated infertility could have preexisting genetic lesions or defects in molecular mechanisms that make them more susceptible to varicocelemediated testicular injury affecting spermatogenesis.

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Polymorphisms of glutathione S-transferase M1 and male infertility in Taiwanese patients with varicocele

Abstract: GST M1- genotype predisposes to increased oxidative damage to sperm of patients with varicocele.

Cited by 71 publications

References 41 publications

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

A multi-faceted approach to understanding male infertility: gene mutations, molecular defects and assisted reproductive techniques (ART)

Genetic polymorphisms in glutathione S-transferase T1 affect the surgical outcome of varicocelectomies in infertile patients

Molecular mechanisms involved in varicocele-associated infertility

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