Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Case-control Study

Xie, Yao; Loh, Marie; Wen, Yan; Huang, He; Lan, Hui Y.; Chen, Feng; Soong, Richie; Yang, Chunxia

doi:10.7314/apjcp.2012.13.11.5637

Cited by 18 publications

(15 citation statements)

References 30 publications

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“…Gastric cancer is a complex disease that is caused by genetic and environmental factors and their interactions (Hamajima et al, 2006;Bai et al, 2008;Pan et al, 2012;Bastos et al, 2013). Increasing evidence indicates that the MTHFR C677T and MTHFR A1298C polymorphisms influence the risk of cancer Tahara et al, 2009;Neves et al, 2010;Saberi et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

“…Based on the incidence and mortality rates of gastric cancer, the absolute number of cases is predicted to increase by the year 2050 (Forman and Burley, 2006). Gastric cancer is caused by multiple factors, including environmental and genetic factors, which may interact to affect tumor promotion and progression (Hamajima et al, 2006;Bai et al, 2008;Pan et al, 2012). Epidemiological studies have indicated that folate metabolism is correlated with an increased risk of gastric cancer, and that low intake of folate and polymorphisms in folate-metabolizing genes affect folate metabolism, and thus affect the susceptibility to gastric cancer (Choi and Mason, 2000;Miao et al, 2002;Götze et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Epidemiological studies have indicated that folate metabolism is correlated with increased risk of gastric cancer. Since methylenetetrahydrofolate reductase (MTHFR) is an important enzyme involved in folate metabolism, in this study, we examined whether polymorphisms and haplotypes of MTHFR are correlated with the risk of gastric cancer. The polymorphisms MTHFR C677T and MTHFR A1298C were genotyped by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis in 285 patients and 570 healthy controls. Association analyses based on binary logistic regression were conducted to determine the odds ratio (OR) and its 95% confidence interval (95%CI) for each genotype. The MTHFR 677TT genotype was significantly related with a reduced risk of gastric cancer (OR = 0.60, 95%CI = 0.39-0.92) compared to the CC genotype. Similarly, the MTHFR 1298CC genotype was significantly MTHFR and risk of gastric cancer associated with a decreased risk of cancer (OR = 0.52, 95%CI = 0.32-0.81). Haplotype analysis showed that the TC haplotype was associated with a reduced risk of gastric cancer compared to the most common haplotype, CA (OR = 0.28, 95%CI = 0.12-0.60). Our results suggest that the MTHFR C677T and MTHFR A1298C polymorphisms are related to gastric cancer susceptibility in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

et al. 2014

Genet. Mol. Res.

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“…However, Hsu et al (2015) found no significant association between XRCC1 gene polymorphisms and skin cancer risk, although in a case-control study, Zhu et al (2015) demonstrated that individuals carrying the Arg194Trp variation in this gene are more susceptible to prostate cancer. Several investigators have scrutinized the association between XRCC1 gene polymorphisms and gastric cancer risk, but their results have been inconsistent (Yan et al, 2009;Engin et al, 2011;Yuan et al, 2011;Karahalil et al, 2012;Pan et al, 2012;Wen et al, 2012). In Turkish populations, Engin et al (2011) and Karahalil et al (2012) found a statistically significant association between the XRCC1 Arg399Gln gene polymorphism and gastric cancer risk in Turkish populations.…”

Section: Discussionmentioning

confidence: 99%

“…In Turkish populations, Engin et al (2011) and Karahalil et al (2012) found a statistically significant association between the XRCC1 Arg399Gln gene polymorphism and gastric cancer risk in Turkish populations. Wen et al (2012), Pan et al (2012), andYuan et al (2011) revealed a significant relationship between the Arg194Trp variant and susceptibility to this disease among Chinese individuals, while Yan et al (2009) reported that Arg399Gln and Arg194Trp sequence alterations have no effect, but the Arg280His polymorphism significantly increases gastric cancer risk. A recent meta-analysis incorporating data from 10,427 participants indicated that the Arg399Gln and Arg280His variants do not influence the occurrence of this malignancy, but the Arg194Trp polymorphism does significantly elevate risk for Asian individuals (Zhao et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

et al. 2016

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ABSTRACT. We carried out a hospital-based case-control study to investigate the role of XRCC1 gene Arg399Gln, Arg280His, and Arg194Trp polymorphisms in susceptibility to gastric cancer. A total of 214 gastric cancer patients and 247 control subjects were recruited between March 2013 and March 2015, and polymorphism genotype frequencies were determined by polymerase chain reactionrestriction fragment length polymorphism. Using the chi-square test, we detected statistically significant differences in age (chi-square = 22.25, P < 0.001), gender (chi-square = 6.74, P = 0.01), and family history of cancer (chi-square = 4.73, P = 0.03) between the case and control groups. Logistic regression analysis revealed that the XRCC1 Arg194Trp TT genotype conferred increased susceptibility to gastric cancer compared to the CC genotype [odds ratio (OR) = 2.38, 95% confidence interval (CI) = 1.28-4.49]. Moreover, individuals carrying the T allele of this variant were found to be at moderately increased risk of this disease (OR = 1.56, 95%CI = 1.16-2.09). However, the XRCC1 2 S. Chen et al. Genetics and Molecular Research 15 (3): gmr.15038342 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer. In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.

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“…However, Li et al studied the role of rs1136410 in the evolution of precancerous gastric lesions in a cohort of 1281 H. pylori-seropositive subjects and found no positive association. Other studies reported that rs1136410 was not related with GC [68,69], and recently, a metaanalysis on this topic showed that rs1136410 was not associated with the risk of GC (table 1) [57]. Given the inconsistencies, more studies are needed on the role of the PARP1 polymorphism in H. pylori-related GC.…”

Section: Dna Repairmentioning

confidence: 96%

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

et al. 2016

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Helicobacter pylori (H. pylori) is the definite carcinogen of gastric cancer. H. pylori infection induces chronic inflammation, causes DNA damage and aberrant methylation of genes and these pathways are involved in H. pylori-related gastric carcinogenesis. Polymorphisms of the genes involved in these pathways could alter susceptibility to gastric cancer. In this mini review, we focused on the role of polymorphisms in these genes on the susceptibility to gastric cancer, with a particular emphasis on their possible interactions with H. pylori infection. We found that many studies on this theme did not simultaneously report H. pylori infection and the interactions remained inconclusive.

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Polymorphisms of XRCC1 and ADPRT Genes and Risk of Noncardia Gastric Cancer in a Chinese Population: a Case-control Study

Cited by 18 publications

References 30 publications

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

Investigating the association between XRCC1 gene polymorphisms and susceptibility to gastric cancer

Interaction Between Helicobacter Pylori and Host Genetic Variants in Gastric Carcinogenesis

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