Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

J, Lin; Rm, Zeng; Rn, Li; Wh, Cao

doi:10.4238/2014.march.24.10

Cited by 19 publications

(20 citation statements)

References 28 publications

(29 reference statements)

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“…It is noteworthy to mention that con icting results have been reported on the in uence of the MTHFR C677T polymorphism on precancerous lesions or cancer. Some studies have shown an increased risk of gastric cancer development among Asians and Caucasians [12,26], while others studies have reported a negative association or null results [27,28]. Con icting results indicate that population-speci c and geographical factors may account for this phenomenon.…”

Section: Discussionmentioning

confidence: 98%

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection : a case control study

Kong

Dang

et al. 2020

Preprint

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Abstract Background: Previous reports indicate that the methylenetetrahydrofolate reductase (MTHFR) 677C>T polymorphism plays a role in gastric cancer. However, whether it influences the development and progression of atrophic gastritis remains unclear. We aimed to determine the possible association between the MTHFR 677C>T polymorphism and the severity of atrophic gastritis.Methods: A total 128 patients without Helicobacter pylori infection were included in the study. The presence and severity of gastric atrophy was assessed by histology using OLGA and OLGIM Gastritis Staging System. MTHFR 677C>T genotyping was performed by digital fluorescence molecular hybridization. Categorical variables were analyzed by percentages using the χ2 test.Results: In this study, the TT genotype was significantly more frequent among Helicobacter pylori-negative patients aged ≤44 years (age ≤44 years vs. >44 years, P=0.039). Patients with the TT genotype showed a higher ratio of incisura with atrophy or intestinal metaplasia (TT vs. CC+CT, P=0.02). Furthermore, the TT genotype was associated with more severe lesions compared with the CC+CT genotypes (TT vs. CC+CT for atrophy: P=0.07; for intestinal metaplasia: P=0.01; for moderate-to-severe lesions: P=0.01). OLGA and OLGIM stages III-IV were observed more frequently in patients with the TT genotype compared with the CC+CT genotypes (for OLGA: P=0.003; for OLGIM: P=0.036).Conclusions: The MTHFR 677C>T TT genotype showed an increased risk of moderate-to-severe lesions by OLGA and OLGIM stages, and these results suggest that the MTHFR C677T polymorphism may serve as a predictive marker for precancerous gastric lesions, especially in Helicobacter pylori-negative patients aged ≤44 years.

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Section: Discussionmentioning

confidence: 98%

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection : a case control study

Kong

Dang

et al. 2020

Preprint

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“… 23 However, other articles showed exactly opposite results about these two polymorphisms. 24 , 25 There are still many controversial results in other cancer types, including prostate cancer, bladder cancer, head and neck cancer, leukemia and lymphoma, nervous system cancers, etc. 26 – 31 …”

Section: Introductionmentioning

confidence: 99%

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Tong¹,

Tong²,

Jin³

et al. 2018

CMAR

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ObjectiveTo examine the relationship between polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene and susceptibility to lung cancer in a female Chinese population.MethodA hospital-based case-control study of 388 cases and 388 controls was conducted. Two polymorphisms in MTHFR were detected using TaqMan methods.ResultsThe MTHFR C677T polymorphism was associated with the risk of lung cancer and lung adenocarcinoma. Carriers with the TT genotype of C677T were observed to have an increased risk of lung cancer and lung adenocarcinoma (the ORs were 1.550 and 1.588, respectively). By contrast, the A1298C polymorphism had a negative relationship with the risk of lung cancer and lung adenocarcinoma; compared with the AA genotype carriers, the CC genotype carriers had a lower risk of lung cancer and adenocarcinoma in the female Chinese population (ORs were 0.302 and 0.215, respectively). In the stratified analyses, we observed only the A1298C polymorphism in the CC genotype carriers with a statistically significant reduction in the risk of non-small-cell lung cancer, compared to the AA genotype carriers. No significant statistical association was found between the MTHFR gene polymorphisms and risk of the residual subtype of lung cancer.ConclusionThis study provides evidence that the MTHFR C677T polymorphism may contribute to the development of lung cancer and lung adenocarcinoma in a female Chinese population. However, the MTHFR A1298C polymorphism may be associated with the decreasing risk of lung cancer.

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“…A number of studies have investigated the effects of genetic polymorphisms related to one‐carbon metabolism on the risk of gastric cancer. However, most of these studies have focused on polymorphisms of the MTHFR , MTR , and MTRR genes , and the results are variable. Such inconsistent results in terms of gastric cancer might be explained by gene–diet interactions.…”

Section: Introductionmentioning

confidence: 99%

Dietary folate, one‐carbon metabolism‐related genes, and gastric cancer risk in Korea

Kim

Woo

Lee

et al. 2015

Molecular Nutrition Food Res

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Aberrant DNA methylation of the P16, MGMT, and hMLH1 genes in combination with the methylenetetrahydrofolate reductase C677T genetic polymorphism and folate intake in gastric cancer

Cited by 19 publications

References 28 publications

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection : a case control study

Association of MTHFR C677T polymorphism with severity and localization of chronic atrophic gastritis patients without Helicobacter pylori infection : a case control study

MTHFR C677T and A1298C polymorphisms and lung cancer risk in a female Chinese population

Dietary folate, one‐carbon metabolism‐related genes, and gastric cancer risk in Korea

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