Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men

Keso, T; Perola, Markus; Laippala, Pékka; Ilveskoski, Erkki; Kunnas, Tarja; Mikkelsson, Jussi; Penttilä, Antti; Hurme, Mikko; Karhunen, Pekka J.

doi:10.1016/s0021-9150(00)00602-x

Cited by 105 publications

(70 citation statements)

References 38 publications

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“…The same studies affirm that the allelic distribution is different according to the geographical origin of the study group (ranging from 24% to 12% for the rare allele) (25,30). However, in contrast to other published data (26,31), this may be due to different genetic and environmental risk factors or to different selection criteria of CAD patients.…”

Section: Discussionmentioning

confidence: 61%

“…Previous cardiovascular studies have investigated the association between several SNPs located in the promoter region of the TNF-a gene and CAD or atherosclerosis (24)(25)(26)(27), but conclusive data regarding the role of TNF-a genotypes in CAD pathogenesis is need-ed. The present study investigated the association between two biallelic polymorphisms of the TNF-a gene and their relation to CAD in an Arab African population.…”

Section: Discussionmentioning

confidence: 99%

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–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Ghazouani

Khalifa²,

Abboud³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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Section: Discussionmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Ghazouani

Khalifa²,

Abboud³

et al. 2009

Clinical Chemistry and Laboratory Medicine

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“…In the Helsinki Sudden Death Study, a polymorphism within the tumor necrosis factor locus was associated with extent of calcified lesions in coronary arteries. 30 In all of these studies, the effects of the genes have been small and no findings have been replicated yet.…”

Section: Discussionmentioning

confidence: 99%

Heritability of Coronary Artery Calcium Quantity Measured by Electron Beam Computed Tomography in Asymptomatic Adults

et al. 2002

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Background-Electron beam computed tomography is an accurate, noninvasive method to detect and quantify coronary artery calcification (CAC), a marker of subclinical and clinical coronary artery atherosclerosis. CAC quantity predicts future coronary artery disease end points in asymptomatic adults, but measured risk factors explain less than half the variability in CAC quantity. Although several candidate genes for CAC have been identified, the relative importance of genetic influences on CAC quantity has not been assessed in asymptomatic adults in a community. Methods and Results-We quantified the relative contributions of measured risk factors and genetic influences on CAC quantity measured by electron beam computed tomography in 698 asymptomatic white adults from 302 families. Before adjusting for any risk factors, 43.5% of the variation in CAC quantity was attributable to genetic factors (Pϭ0.0007). Independent predictors of CAC quantity were identified with stepwise linear regression. After adjusting for these risk factors, including age, sex, fasting glucose level, systolic blood pressure, pack-years of smoking, and LDL cholesterol, 41.8% of the residual variation in CAC quantity was attributable to genetic factors (Pϭ0.0003). Conclusions-These results demonstrate the importance of genetic factors in subclinical coronary atherosclerosis variation as measured by CAC quantity. The presence of genetic effects suggests that unknown genes that influence CAC quantity are yet to be identified. (Circulation. 2002;106:304-308.)

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“…The G(-308)A polymorphism has been related to MI [13], to unstable angina [16], and ST-elevation MI (STEMI) [20]. Other studies failed to demonstrate an association between this polymorphism and MI [12,14,15]. This discordance may be due to the multifactorial nature of the MI, to differences in study design or to genetic heterogeneity within and between the populations studied.…”

Section: Discussionmentioning

confidence: 99%

“…A polymorphism that affects its transcription has been identified in the promoter region of the gene, a guanineto-adenosine transition at -308 bp in the promoter region (termed the A allele). In some studies but not in others, an association between this polymorphism and CAD was demonstrated [12][13][14][15][16]. Since this polymorphism has not been tested as a potential marker of MI in DM2, we investigated whether it is associated with increased serum levels of TNFα, and whether it is associated with increased risk for MI in patients.…”

Section: Introductionmentioning

confidence: 99%

The TNFα Gene G(-308)A Polymorphism as a Marker for Myocardial Infarction in Type 2 Diabetes Mellitus

Reschner¹,

Steblovnik²,

Milutinović³

et al. 2008

Balkan Journal of Medical Genetics

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Type-2 diabetes mellitus (DM2) is a major risk factor for the development of coronary artery disease (CAD) and subsequent myocardial infarction (MI). Because the pro-inflammatory cytokine tumor necrosis factor α (TNFα) takes part in several stages of the development of atherosclerosis, we investigated the association of the TNFα gene G(-308)A polymorphism with MI in 142 DM2 patients and in 310 patients who had had DM2 for over 10 years with no clinical signs of CAD and measured the serum TNFα levels in 70 consecutive DM2 patients: 10 with MI and 60 without MI.We found no association between the G(-308)A polymorphism and MI in DM2 [odds ratio (OR) = 0.8, 95% confidence interval (CI) = 0.5-1.3, p = 0.4 for the recessive model and OR = 0.8, 95% CI = 0.2-2.8, p = 0.7 for the dominant model]. Significantly higher TNFα serum levels were found in 58 DM2 patients with the GG genotype compared to 12 with the AG genotype (1.13 ± 0.6 ng/L vs. 0.53 ± 0.35 ng/L, p <0.01). We concluded that the TNFα gene G(-308)A polymorphism is not a risk factor for MI with DM2 in Slovenes of Slavic origin.

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Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men

Cited by 105 publications

References 38 publications

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery disease

Heritability of Coronary Artery Calcium Quantity Measured by Electron Beam Computed Tomography in Asymptomatic Adults

The TNFα Gene G(-308)A Polymorphism as a Marker for Myocardial Infarction in Type 2 Diabetes Mellitus

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