Polymorphous low-grade adenocarcinoma of parotid gland: A rare occurrence

Background: The tumors of the salivary glands are uncommon head and neck neoplasms. The aim of this study was to evaluate the relative frequencies, types, site distribution and the histopathological features of salivary gland tumors. Materials and Methods: This was a retrospective study of 176 cases of salivary gland tumors collected from medical record section and department of pathology at B.P.Koirala Memorial Cancer Hospital from Jan. 2005 to Dec. 2010. Tumors were analyzed based on demographics, anatomic location and histopathological type. Results: Out of 176 cases, 66 (37.5 %) were benign and 110 (62.5 %) were malignant with M:F ratio of 1.7:1. The mean age observed was 44.76 years with age range of 12 to 75 years. Pleomorphic adenoma was found to be the commonest benign tumor (72.7 %), followed by Warthin tumor (15.1%), monomorphic adenoma (3.0 %) and basal cell adenoma (3.0 %). The mucoepidermoid carcinoma was the most common malignant tumor (38.1 %), followed by adenoid cystic carcinoma (25.4%), acinic cell carcinoma (10.9%), adenocarcinoma NOS (6.3%), carcinoma ex pleomorphic adenoma (5.4%) and unclassified malignant tumor (4.5 %). Parotid was the most common site for the location of tumors (70.4%) followed by submandibular (19.3%) and minor salivary glands (10.2 %). Conclusion: Pleomorphic adenoma was the commonest salivary gland tumor observed in both sexes. Mucoepidermoid carcinoma was the most common malignant salivary gland tumor. The parotid gland was the most common site of origin in both benign and malignant tumors. DOI: http://dx.doi.org/10.3126/jpn.v4i7.10291 Journal of Pathology of Nepal (2014) Vol. 4, 520-524

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“…Although several report have described PLGA of the parotid gland. 27,28 We found two cases (3.0 %) of PLGA in parotid gland.…”

Section: Discussionmentioning

confidence: 74%

Histopathological Pattern of Salivary Gland Tumors

et al. 2014

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“…Although several report have described PLGA of the major salivary glands. 1,4,6,[7][8] Experience with cytology diagnosis is limited to some case reports. [9][10][11] FNA is widely used in other head and neck sites, including the major salivary glands and cervical lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…Much less frequently cases have been described in major glands, usually but not always against a background of pleomorphic adenoma. 1 Histologically various architectural patterns (like lobular, papillary and solid) are seen with bland cytological features. Infiltration into the surrounding tissues is focally seen.…”

Section: Introductionmentioning

confidence: 99%

Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

et al. 2012

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Polymorphous low-grade adenocarcinoma is a rare salivary gland malignant tumor of low aggressiveness, commonly occurring in minor salivary glands. Its origin in major salivary glands is considered exceedingly rare. We report a case of polymorphous low grade adenocarcinoma arising from left parotid in a 21-yearold female patient.Journal of Pathology of Nepal (2012) Vol. 2, 331-334DOI: http://dx.doi.org/10.3126/jpn.v2i4.6890

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“…[1,2] PLGA is a malignant neoplasm of salivary glands with low aggressiveness, exclusively found in minor salivary glands. [3] CASE REPORT: A 65 years old female patient presented with a palatal swelling since 3 years. On examination non-tender, non-ulcerated mass of 4x3 cm was seen attached to hard palate extending posteriorly into the soft palate.…”

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confidence: 99%

Swelling on the Hard Palate Presenting as Polymorphous Low Grade Adenocarcinoma: A Case Report and Review of Literature

Chandekar¹,

Dantkale²,

Narkhede³

et al. 2014

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Polymorphous Low Grade Adenocarcinoma (PLGA) is a relatively newer entity under the sub-classification of adenocarcinoma, which arises mainly from the minor salivary glands. PLGA is difficult to diagnose both clinically and histopathologically due to its indolent presentation and its morphological diversity that includes several microscopic patterns. It is an uncommon malignant neoplasm with low aggressiveness accounting for about 2% of all salivary gland tumours. We are reporting this case of PLGA which arose from the minor salivary gland over the hard palate.

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Polymorphous low-grade adenocarcinoma of parotid gland: A rare occurrence

Cited by 7 publications

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Histopathological Pattern of Salivary Gland Tumors

Histopathological Pattern of Salivary Gland Tumors

Polymorphous low grade adenocarcinoma of the parotid gland: A case report with cytohistological correlation and its immunohistochemical study

Swelling on the Hard Palate Presenting as Polymorphous Low Grade Adenocarcinoma: A Case Report and Review of Literature

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