Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells

Abdolahad, Mohammad; Janmaleki, Mohsen; Mohajerzadeh, S.; Akhavan, Omid; Abbasi, Sedigheh

doi:10.1016/j.msec.2012.12.052

Cited by 66 publications

(29 citation statements)

References 62 publications

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“…Over 90% cell confluence was observed at the highest concentration (50 μg/mL), even for GO. This is, however, in accordance with previous findings, 77 where more than 87% HT-29 cell viability was observed for graphene. A similar finding was also observed for other types of cancer cells such as HeLa cancer cells, 78 where cell viability of 90% was observed for GO at 40 μg/mL.…”

supporting

confidence: 93%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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Purpose A simple, one-pot strategy was used to synthesize reduced graphene oxide (RGO) nanosheets by utilizing an easily available over-the-counter medicinal and edible mushroom, Ganoderma lucidum . Methods The mushroom was boiled in hot water to liberate the polysaccharides, the extract of which was then used directly for the reduction of graphene oxide. The abundance of polysaccharides present in the mushroom serves as a good reducing agent. The proposed strategy evades the use of harmful and expensive chemicals and avoids the typical tedious reaction methods. Results More importantly, the mushroom extract can be easily separated from the product without generating any residual byproducts and can be reused at least three times with good conversion efficiency (75%). It was readily dispersible in water without the need of ultrasonication or any surfactants; whereas 5 minutes of ultrasonication with various solvents produced RGO which was stable for the tested period of 1 year. Based on electrochemical measurements, the followed method did not jeopardize RGO’s electrical conductivity. Moreover, the obtained RGO was highly biocompatible to not only colon (HT-29) and brain (U87MG) cancer cells, but was also viable towards normal cells (MRC-5). Conclusion Besides being eco-friendly, this mushroom based approach is easily scalable and demonstrates remarkable RGO stability and biocompatibility, even without any form of functionalization.

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supporting

confidence: 93%

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Muthoosamy

Bai

Abubakar

et al. 2015

IJN

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“…As can be seen from Figures 8 and 9, the hydrophilic GO and ginseng-rGO films exhibited better attachment and higher proliferation, in contrast with the hydrophobic PDMS substrate and the hydrazine-rGO film. This can be attributed to higher biocompatibility of the GO and ginseng-rGO films, due to the presence of the oxygen groups on GO and ginsenosides on surface of the rGO sheets (as previously observed for high attachment of SW48 cancer cells to rGO sheets reduced and functionalized by polyphenols of green tea [89]). It should be nothed that, cyto-and even geno-toxicity of graphene sheets is mainly assigned to i) the reactive oxygen species (ROS) generated by graphene at high concentrations (~100 μg/mL) and/or ii) the direct contact interaction of extremely sharp edges of graphene with membrane and even nucleus of cells [8,90,91].…”

Section: Resultssupporting

confidence: 61%

Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets

Akhavan

Ghaderi

Abouei

et al. 2014

Carbon

224

133

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“…Recent publications have shown the interesting potential of GO for PTT applications (see Table 1 ) 28 , 36 , 61 - 64 , 81 - 84 , 95 - 109 . PTT has been reported either alone 95 , 98 , 99 , 105 , 108 - 110 or in combination with drugs 36 , 61 , 62 , 64 , 82 , 104 , 111 or with PDT 102 , 103 , 106 or in both ( Figure 2 B) . Photosensitizing agents are employed in PTT to generate heat from light absorption, leading to photoablation of cancer cells and subsequent cell death.…”

Section: Photothermal Therapymentioning

confidence: 99%

“…Robinson et al 95 used rGO non covalently PEGylated and conjugated to a peptide for targeting and selective photoablation of cancer cells at a low doses. Abdolahad et al 99 used rGO linked to the aromatic rings of green tea. Green tea is well known for its possible anticancer activity; indeed its polyphenol groups could be bound to cancer cell surface receptors.…”

Section: Photothermal Therapymentioning

confidence: 99%

Graphene as Cancer Theranostic Tool: Progress and Future Challenges

Orecchioni¹,

Cabizza²,

Bianco³

et al. 2015

Theranostics

247

138

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Nowadays cancer remains one of the main causes of death in the world. Current diagnostic techniques need to be improved to provide earlier diagnosis and treatment. Traditional therapy approaches to cancer are limited by lack of specificity and systemic toxicity. In this scenario nanomaterials could be good allies to give more specific cancer treatment effectively reducing undesired side effects and giving at the same time accurate diagnosis and successful therapy. In this context, thanks to its unique physical and chemical properties, graphene, graphene oxide (GO) and reduced graphene (rGO) have recently attracted tremendous interest in biomedicine including cancer therapy.Herein we analyzed all studies presented in literature related to cancer fight using graphene and graphene-based conjugates. In this context, we aimed at the full picture of the state of the art providing new inputs for future strategies in the cancer theranostic by using of graphene.We found an impressive increasing interest in the material for cancer therapy and/or diagnosis. The majority of the works (73%) have been carried out on drug and gene delivery applications, following by photothermal therapy (32%), imaging (31%) and photodynamic therapy (10%). A 27% of the studies focused on theranostic applications. Part of the works here discussed contribute to the growth of the theranostic field covering the use of imaging (i.e. ultrasonography, positron electron tomography, and fluorescent imaging) combined to one or more therapeutic modalities. We found that the use of graphene in cancer theranostics is still in an early but rapidly growing stage of investigation. Any technology based on nanomaterials can significantly enhance their possibility to became the real revolution in medicine if combines diagnosis and therapy at the same time. We performed a comprehensive summary of the latest progress of graphene cancer fight and highlighted the future challenges and the innovative possible theranostic applications.

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Polyphenols attached graphene nanosheets for high efficiency NIR mediated photodestruction of cancer cells

Cited by 66 publications

References 62 publications

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Exceedingly biocompatible and thin-layered reduced graphene oxide nanosheets using an eco-friendly mushroom extract strategy

Accelerated differentiation of neural stem cells into neurons on ginseng-reduced graphene oxide sheets

Graphene as Cancer Theranostic Tool: Progress and Future Challenges

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