Polypropylene surgical thread with complex biological activity

Жуковский, В. А.

doi:10.1007/bf01060997

Cited by 3 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vicryl Plus is a synthetic absorbable suture composed of a glycolide/L‐lactide copolymer coated with triclosan, an antibacterial agent. Since then, numerous research studies have attempted to endow modern medical fibers with bioactive properties.…”

Section: Introductionmentioning

confidence: 99%

“…Vicryl Plus is a synthetic absorbable suture composed of a glycolide/L-lactide copolymer coated with triclosan, an antibacterial agent. Since then, numerous research studies [2][3][4][5] have attempted to endow modern medical fibers with bioactive properties. Polyglycolide (PGA) was the material chosen for the first synthetic absorbable suture commercialized in the 1970s under the name Dexon (Sherwood-Davis & Geck).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Nochos

Andrikopoulos

Voyiatzis

2016

J of Applied Polymer Sci

View full text Add to dashboard Cite

The current work focuses on Maxon, a modern biocompatible/bioabsorbable polymer, utilized in the fabrication of surgical sutures, and attempts to explore the limits of controlling the administration rate of a properly incorporated model drug, mitoxandrone dihydrochloride. The control is attempted by tailoring both the structural properties of the host polymer, more specifically its crystallinity and anisotropy, and the level of drug dispersion achieved after following different incorporation methods such as melt and dissolution mixing. The results, based on optical and electron microscopy, differential scanning calorimetry, Fourier transform infrared spectroscopy, and UV–vis spectroscopy, indicate that the structural parameters invoked may enable fine‐tuning of the drug dose released within a 60‐day period. Additionally, the burst effect of the active agent at the early stages of release is regulated by adjusting the drug dispersion level. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43915.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Nochos

Andrikopoulos

Voyiatzis

2016

J of Applied Polymer Sci

View full text Add to dashboard Cite

show abstract

“…The characteristics of PP such as superior chemical resistance and proper mechanical properties, as well as low cost, make it the best candidate in biologically active materials. Clinical trials of PP thread with gentamicin in surgery of malignant tumors at the gastrointestinal tract have been already reported . It is in that sense that we selected PP as a matrix for mitoxantrone drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Quantitative surface enhanced Raman scattering measurements at the early stage of active agent release processes

Anastasopoulos

Beobide

Voyiatzis

2012

J Raman Spectroscopy

View full text Add to dashboard Cite

The surface enhanced Raman scattering spectroscopy (SERS) is introduced as a new method to probe the initial release of active agents from controlled delivery systems. As a model system, mitoxantrone‐loaded polypropylene specimens immersed in water have been utilized. Surface enhanced resonance Raman scattering (SERRS) measurements allowed the quantitative delineation of the initial drug release profile. SERRS was also compared in early stage release processes with UV–vis absorption often used in traditional quantitative analysis via HPLC, a common technique for controlled release evaluation. More and above the high selectivity of the Raman Effect, SERS has been proved as a highly sensitive method to quantitatively monitor the initial release of the medicine even at the very early stage of the delivery process; UV–vis absorbance was unable to respond accordingly. Copyright © 2012 John Wiley & Sons, Ltd.

show abstract

A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values

Morellon‐Sterling

Tavano

Bolívar

et al. 2022

International Journal of Biological Macromolecules

View full text Add to dashboard Cite

Polypropylene surgical thread with complex biological activity

Cited by 3 publications

References 1 publication

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Manipulation of the drug‐release behavior of poly(glycolide‐co‐trimethylene carbonate)

Quantitative surface enhanced Raman scattering measurements at the early stage of active agent release processes

A review on the immobilization of pepsin: A Lys-poor enzyme that is unstable at alkaline pH values

Contact Info

Product

Resources

About