Polypyrrole confined in dendrimer-like silica nanoparticles for combined photothermal and chemotherapy of cancer

Abstract

A multifunctional drug delivery system with polypyrrole confined in dendrimer-like silica nanoparticles and DOX loading for chemo-photothermal synergistic therapy of cancer.

Dendritic Fibrous Nanosilica for Catalysis, Energy Harvesting, Carbon Dioxide Mitigation, Drug Delivery, and Sensing

“…For example, photothermal ablation (PTA) therapy uses heat produced from the conversion of light energy to kill cancer cells in a selected region. Fibrous nanosilica (DFNS) was used in the development of a PTA‐based therapy . Polypyrrole (PPy), a near‐infrared (NIR) light‐absorbing polymer, was loaded inside the fibers of DFNS nanoparticles, denoted DSNs (dendrimer such as silica nanoparticles), by the FeCl 3 ‐assisted in situ polymerization of pyrrole monomers.…”

Novel approach in synthesizing ternary GO‐Fe3O4‐PPy nanocomposites for high Photothermal performance

“…Especially, polypyrrole nanoparticles (PPy NPs), which are used in a wide range of biomedical applications such as biosensors, tissue engineering, and drug delivery, are one of the most remarkable polymeric materials due to its unique properties such as ease of synthesis with high yield and low cost, high stability, and conductivity . Furthermore, PPy NPs with vigorous NIR absorbance are considered to be excellent photothermal component due to their advantages such as high photothermal conversion efficiency, long‐term photothermal stability and nontoxicity compared to the widely studied inorganic nanoparticles (such as quantum dots, Au, Ag) for photothermal therapy application …”

“…2,18,32,33 Furthermore, PPy NPs with vigorous NIR absorbance are considered to be excellent photothermal component due to their advantages such as high photothermal conversion efficiency, long-term photothermal stability and nontoxicity compared to the widely studied inorganic nanoparticles (such as quantum dots, Au, Ag) for photothermal therapy application. 2,34,35 In the current work, ternary magnetic GO-Fe 3 O 4 -PPy nanocomposites having excellent stability and photothermal performance were synthesized with a facile two-step modified procedure. In the first step, highly magnetic GO-Fe 3 O 4 structure prepared with co-precipitation method.…”

Near infrared light mediated photochemotherapy for efficiently treating deep orthotopic tumors guided by ultrasound imaging

“…Hyperthermia in the combined treatment of cancer has attracted great attention during the last two decades (Wust et al, 2002;Chen et al, 2016b;Moy & Tunnell, 2017). At present, chemotherapy is still the main method of cancer treatment, but chemotherapeutic agents typically lack selectivity, thus leading to a low efficacy of chemotherapy in cancer cells and high toxicity to normal cells (Greish, 2007).…”

“…Recently, photothermal therapy combined with cancer chemotherapy (Photothermal-chemotherapy) has become a highly promising strategy in cancer treatment given its ideal features, such as enhanced therapeutic efficacy, controlled drug release and reduced systemic toxicity (Chen et al, 2016a). It was noted that most studies of photothermal-chemotherapy in cancer were investigated only at the cellular level or by using conventional subcutaneous xenograft tumor models, because photothermal combined treatment typically involved in the irradiation of tumors with near-infrared (NIR) light (Chen et al, 2016b). In addition, this method is very convenient for the treatment of subcutaneous xenograft tumor models (Liao et al, 2015).…”