Polysaccharide-Based Biomaterials for Protein Delivery

Wang, Kaili; Liu, Mingqi; Mo, Ran

doi:10.1016/j.medidd.2020.100031

Cited by 25 publications

(17 citation statements)

References 92 publications

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“…Feather keratin (FK) was used for the dual crosslinking of HA to prepare NGs for DOX delivery [65] as it is illustrated in Figure 10. Ionic crosslinking between the carboxyl groups of HA and the amino groups of keratin-induced pH responsiveness while covalent disulfide bonds with H2O2 made the NG structure reduction responsive [106]. Increasing the feeding amount of HA led to smaller nanoparticles of hydrodynamic size 300-400 nm with relatively narrow and monomodal distribution.…”

Section: Polysaccharide Ngs and Mgs Formed By Electrostatic Complexat...mentioning

confidence: 99%

“…Nanostructures of polysaccharides are currently used for the delivery of proteins to take advantage of the increased stability, permeability and bioavailability of the protein-involving therapies [ 106 ]. Cholesterol-bearing pullulan (Pull) was modified by acryloyl groups to prepare NGs for tongue muscle regeneration.…”

Section: Medical Applications Of Polysaccharide Ngs and Mgsmentioning

confidence: 99%

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Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

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Polysaccharides are natural polymers with hydrophilic, biocompatible and biodegradable characteristics and have many opportunities in the food and pharmaceutical sectors. This review focuses on the field of nano and microstructures whose internal structure is based on networked polysaccharide chains in 3D i.e., polysaccharide nanogels (NGs) and microgels (MGs). As it is observed the number of articles on NGs and MGs in peer reviewed scientific journals has been increasing over the last two decades. At the same time, the relative contribution of polysaccharides in this field is gaining place. This review focuses on the different applied methods for the fabrication of a variety of polysaccharide-based NGs and MGs and aims to highlight the recent advances on the subject and present their potentials and properties with regards to their integration in aspects of medicinal and food sciences. The presentation of the recent advances in the application of polysaccharide NGs and MGs is divided in materials with potential as emulsion stabilizers and materials with potential as carriers of bioactives. For applications in the medical sector the division is based on the fabrication processes and includes self-assembled, electrostatically complexed/ionically crosslinked and chemically crosslinked NGs and MGs. It is concluded that many advances are expected in the application of these polysaccharide-based materials and in particular as nutrient-loaded emulsion stabilizers, viscosity modifiers and co-assembled structures in combination with proteins.

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Section: Polysaccharide Ngs and Mgs Formed By Electrostatic Complexat...mentioning

confidence: 99%

Section: Medical Applications Of Polysaccharide Ngs and Mgsmentioning

confidence: 99%

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Papagiannopoulos

Sotiropoulos²

2022

Polymers

View full text Add to dashboard Cite

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“…Similarly, present studies have extended the research on different MNs types to include the components of critical therapeutic substances through the skin [24]. Therefore, advancing the review on several of these substances, including polysaccharides biomaterials, a more recent study has utilized the PRISMA guidelines to review the same for medical applications [25,26]. This shows that the goal of achieving clinical translation from the bench is in progress.…”

Section: Introductionmentioning

confidence: 89%

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

et al. 2022

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In this focused progress review, the most widely accepted methods of transdermal drug delivery are hypodermic needles, transdermal patches and topical creams. However, microneedles (MNs) (or microneedle arrays) are low-invasive 3D biomedical constructs that bypass the skin barrier and produce systemic and localized pharmacological effects. In the past, biomaterials such as carbohydrates, due to their physicochemical properties, have been extensively used to manufacture microneedles (MNs). Due to their wide range of functional groups, carbohydrates enable the design and development of tunable properties and functionalities. In recent years, numerous microneedle products have emerged on the market, although much research needs to be undertaken to overcome the various challenges before the successful introduction of microneedles into the market. As a result, carbohydrate-based microarrays have a high potential to achieve a future step in sensing, drug delivery, and biologics restitution. In this review, a comprehensive overview of carbohydrates such as hyaluronic acid, chitin, chitosan, chondroitin sulfate, cellulose and starch is discussed systematically. It also discusses the various drug delivery strategies and mechanical properties of biomaterial-based MNs, the progress made so far in the clinical translation of carbohydrate-based MNs, and the promotional opportunities for their commercialization. In conclusion, the article summarizes the future perspectives of carbohydrate-based MNs, which are considered as the new class of topical drug delivery systems.

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“…Additionally, one of the most common challenges associated with natural polysaccharide-based hydrogels is the wide variability in their molecular weight which requires advanced purification and sophisticated analytical technologies for assessment (Wang et al, 2020). On the other hand, proteins or peptides generally possess a definite amino acids sequence, fixed molecular weight, uniform physicochemical properties, and show less batch to batch variation.…”

Section: Advantages Of Protein Nanohydrogels Over Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Protein-Based Nanohydrogels for Bioactive Delivery

et al. 2021

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Hydrogels possess a unique three-dimensional, cross-linked network of polymers capable of absorbing large amounts of water and biological fluids without dissolving. Nanohydrogels (NGs) or nanogels are composed of diverse types of polymers of synthetic or natural origin. Their combination is bound by a chemical covalent bond or is physically cross-linked with non-covalent bonds like electrostatic interactions, hydrophobic interactions, and hydrogen bonding. Its remarkable ability to absorb water or other fluids is mainly attributed to hydrophilic groups like hydroxyl, amide, and sulphate, etc. Natural biomolecules such as protein- or peptide-based nanohydrogels are an important category of hydrogels which possess high biocompatibility and metabolic degradability. The preparation of protein nanohydrogels and the subsequent encapsulation process generally involve use of environment friendly solvents and can be fabricated using different proteins, such as fibroins, albumin, collagen, elastin, gelatin, and lipoprotein, etc. involving emulsion, electrospray, and desolvation methods to name a few. Nanohydrogels are excellent biomaterials with broad applications in the areas of regenerative medicine, tissue engineering, and drug delivery due to certain advantages like biodegradability, biocompatibility, tunable mechanical strength, molecular binding abilities, and customizable responses to certain stimuli like ionic concentration, pH, and temperature. The present review aims to provide an insightful analysis of protein/peptide nanohydrogels including their preparation, biophysiochemical aspects, and applications in diverse disciplines like in drug delivery, immunotherapy, intracellular delivery, nutraceutical delivery, cell adhesion, and wound dressing. Naturally occurring structural proteins that are being explored in protein nanohydrogels, along with their unique properties, are also discussed briefly. Further, the review also covers the advantages, limitations, overview of clinical potential, toxicity aspects, stability issues, and future perspectives of protein nanohydrogels.

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Polysaccharide-Based Biomaterials for Protein Delivery

Cited by 25 publications

References 92 publications

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Current Advances of Polysaccharide-Based Nanogels and Microgels in Food and Biomedical Sciences

Microneedle-Based Natural Polysaccharide for Drug Delivery Systems (DDS): Progress and Challenges

Protein-Based Nanohydrogels for Bioactive Delivery

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